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Salivary duct carcinoma with rhabdoid features: report of 2 cases with immunohistochemical and ultrastructural analyses.

Kusafuka K, Onitsuka T, Muramatsu K, Miki T, Murai C, Suda T, Fuke T, Kamijo T, Iida Y, Nakajima T - Head Neck (2013)

Bottom Line: This submandibular tumor was also composed of both residual pleomorphic adenoma region and invasive adenocarcinoma components, whereas some metastatic lesions were purely composed of rhabdoid cells.Such cells were strongly and diffusely positive for cytokeratins (CKs), gross cystic disease fluid protein-15 (GCDFP), and androgen receptor (AR).Case 1 was also positive for Her-2 and p53.

View Article: PubMed Central - PubMed

Affiliation: Pathology Division, Shizuoka Cancer Center, Shizuoka, Japan.

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Related in: MedlinePlus

Pathological findings of case 2. (A) Macroscopically, the main tumor showed cystic change (asterisks) and included a yellowish nodule (black arrows). The tumor expanded from the right submandibular gland (white arrows). (B) Low magnification view of histology indicated a hyalinized nodule, which was a preexisting pleomorphic adenoma (arrows), and the invasive component around the nodule, which was accompanied with cystic change (asterisk; whole mount hematoxylin-eosin stain section). (C) Invasive component showed sheet-like growth of adenocarcinoma cells with central necrosis (hematoxylin-eosin stain: original magnification ×200). (D) Part of the metastatic lesions showed diffuse proliferation of rhabdoid cells, which were similar to those of case 1 (hematoxylin-eosin stain: original magnification ×200).
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fig03: Pathological findings of case 2. (A) Macroscopically, the main tumor showed cystic change (asterisks) and included a yellowish nodule (black arrows). The tumor expanded from the right submandibular gland (white arrows). (B) Low magnification view of histology indicated a hyalinized nodule, which was a preexisting pleomorphic adenoma (arrows), and the invasive component around the nodule, which was accompanied with cystic change (asterisk; whole mount hematoxylin-eosin stain section). (C) Invasive component showed sheet-like growth of adenocarcinoma cells with central necrosis (hematoxylin-eosin stain: original magnification ×200). (D) Part of the metastatic lesions showed diffuse proliferation of rhabdoid cells, which were similar to those of case 1 (hematoxylin-eosin stain: original magnification ×200).

Mentions: Macroscopically, case 2 showed an ill-defined grayish-white mass with markedly cystic change in the right submandibular gland. A yellowish elastic-hard nodule was seen in this main mass (Figure 3A and 3B).


Salivary duct carcinoma with rhabdoid features: report of 2 cases with immunohistochemical and ultrastructural analyses.

Kusafuka K, Onitsuka T, Muramatsu K, Miki T, Murai C, Suda T, Fuke T, Kamijo T, Iida Y, Nakajima T - Head Neck (2013)

Pathological findings of case 2. (A) Macroscopically, the main tumor showed cystic change (asterisks) and included a yellowish nodule (black arrows). The tumor expanded from the right submandibular gland (white arrows). (B) Low magnification view of histology indicated a hyalinized nodule, which was a preexisting pleomorphic adenoma (arrows), and the invasive component around the nodule, which was accompanied with cystic change (asterisk; whole mount hematoxylin-eosin stain section). (C) Invasive component showed sheet-like growth of adenocarcinoma cells with central necrosis (hematoxylin-eosin stain: original magnification ×200). (D) Part of the metastatic lesions showed diffuse proliferation of rhabdoid cells, which were similar to those of case 1 (hematoxylin-eosin stain: original magnification ×200).
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4296234&req=5

fig03: Pathological findings of case 2. (A) Macroscopically, the main tumor showed cystic change (asterisks) and included a yellowish nodule (black arrows). The tumor expanded from the right submandibular gland (white arrows). (B) Low magnification view of histology indicated a hyalinized nodule, which was a preexisting pleomorphic adenoma (arrows), and the invasive component around the nodule, which was accompanied with cystic change (asterisk; whole mount hematoxylin-eosin stain section). (C) Invasive component showed sheet-like growth of adenocarcinoma cells with central necrosis (hematoxylin-eosin stain: original magnification ×200). (D) Part of the metastatic lesions showed diffuse proliferation of rhabdoid cells, which were similar to those of case 1 (hematoxylin-eosin stain: original magnification ×200).
Mentions: Macroscopically, case 2 showed an ill-defined grayish-white mass with markedly cystic change in the right submandibular gland. A yellowish elastic-hard nodule was seen in this main mass (Figure 3A and 3B).

Bottom Line: This submandibular tumor was also composed of both residual pleomorphic adenoma region and invasive adenocarcinoma components, whereas some metastatic lesions were purely composed of rhabdoid cells.Such cells were strongly and diffusely positive for cytokeratins (CKs), gross cystic disease fluid protein-15 (GCDFP), and androgen receptor (AR).Case 1 was also positive for Her-2 and p53.

View Article: PubMed Central - PubMed

Affiliation: Pathology Division, Shizuoka Cancer Center, Shizuoka, Japan.

Show MeSH
Related in: MedlinePlus