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Salivary duct carcinoma with rhabdoid features: report of 2 cases with immunohistochemical and ultrastructural analyses.

Kusafuka K, Onitsuka T, Muramatsu K, Miki T, Murai C, Suda T, Fuke T, Kamijo T, Iida Y, Nakajima T - Head Neck (2013)

Bottom Line: This submandibular tumor was also composed of both residual pleomorphic adenoma region and invasive adenocarcinoma components, whereas some metastatic lesions were purely composed of rhabdoid cells.Such cells were strongly and diffusely positive for cytokeratins (CKs), gross cystic disease fluid protein-15 (GCDFP), and androgen receptor (AR).Case 1 was also positive for Her-2 and p53.

View Article: PubMed Central - PubMed

Affiliation: Pathology Division, Shizuoka Cancer Center, Shizuoka, Japan.

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Related in: MedlinePlus

Histological findings of case 1. (A) The tumor showed a hyalinized nodule in the central area and an invasive component around it (whole mount hematoxylin-eosin stained section). (B) Part of the hyalinized nodule (B area in A: hematoxylin-eosin stain: original magnification ×200) showed spindle-shaped neoplastic myoepithelial cells in the myxoid stroma, which showed the typical histology of pleomorphic adenoma. (C) Atypical ductal carcinoma in situ component (C area in A: hematoxylin-eosin stain: original magnification ×200) was observed in the peripheral portion of pleomorphic adenoma. (D) Invasive component (D area in A: hematoxylin-eosin stain: original magnification ×200) showed the diffuse growth of noncoherent, ovoid-shaped, carcinoma cells. (D: inset: hematoxylin-eosin stain: original magnification ×400) Carcinoma cells showed eccentric nuclei, marked cellular atypia and 1 large nucleolus with eosinophilic cytoplasm. (E) Typical histology of salivary duct carcinoma, which consisted of irregular-shaped atypical glands with eosinophilic cytoplasm, relatively large cytoplasm and marked nuclear atypia, was seen at the invasive component (E area in A: hematoxylin-eosin stain: original magnification ×200).
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fig02: Histological findings of case 1. (A) The tumor showed a hyalinized nodule in the central area and an invasive component around it (whole mount hematoxylin-eosin stained section). (B) Part of the hyalinized nodule (B area in A: hematoxylin-eosin stain: original magnification ×200) showed spindle-shaped neoplastic myoepithelial cells in the myxoid stroma, which showed the typical histology of pleomorphic adenoma. (C) Atypical ductal carcinoma in situ component (C area in A: hematoxylin-eosin stain: original magnification ×200) was observed in the peripheral portion of pleomorphic adenoma. (D) Invasive component (D area in A: hematoxylin-eosin stain: original magnification ×200) showed the diffuse growth of noncoherent, ovoid-shaped, carcinoma cells. (D: inset: hematoxylin-eosin stain: original magnification ×400) Carcinoma cells showed eccentric nuclei, marked cellular atypia and 1 large nucleolus with eosinophilic cytoplasm. (E) Typical histology of salivary duct carcinoma, which consisted of irregular-shaped atypical glands with eosinophilic cytoplasm, relatively large cytoplasm and marked nuclear atypia, was seen at the invasive component (E area in A: hematoxylin-eosin stain: original magnification ×200).

Mentions: Macroscopically, case 1 showed an ill-defined grayish-white mass in the left parotid gland. A whitish elastic-hard nodule was seen in this main mass (Figure 2A).


Salivary duct carcinoma with rhabdoid features: report of 2 cases with immunohistochemical and ultrastructural analyses.

Kusafuka K, Onitsuka T, Muramatsu K, Miki T, Murai C, Suda T, Fuke T, Kamijo T, Iida Y, Nakajima T - Head Neck (2013)

Histological findings of case 1. (A) The tumor showed a hyalinized nodule in the central area and an invasive component around it (whole mount hematoxylin-eosin stained section). (B) Part of the hyalinized nodule (B area in A: hematoxylin-eosin stain: original magnification ×200) showed spindle-shaped neoplastic myoepithelial cells in the myxoid stroma, which showed the typical histology of pleomorphic adenoma. (C) Atypical ductal carcinoma in situ component (C area in A: hematoxylin-eosin stain: original magnification ×200) was observed in the peripheral portion of pleomorphic adenoma. (D) Invasive component (D area in A: hematoxylin-eosin stain: original magnification ×200) showed the diffuse growth of noncoherent, ovoid-shaped, carcinoma cells. (D: inset: hematoxylin-eosin stain: original magnification ×400) Carcinoma cells showed eccentric nuclei, marked cellular atypia and 1 large nucleolus with eosinophilic cytoplasm. (E) Typical histology of salivary duct carcinoma, which consisted of irregular-shaped atypical glands with eosinophilic cytoplasm, relatively large cytoplasm and marked nuclear atypia, was seen at the invasive component (E area in A: hematoxylin-eosin stain: original magnification ×200).
© Copyright Policy - open-access
Related In: Results  -  Collection

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Show All Figures
getmorefigures.php?uid=PMC4296234&req=5

fig02: Histological findings of case 1. (A) The tumor showed a hyalinized nodule in the central area and an invasive component around it (whole mount hematoxylin-eosin stained section). (B) Part of the hyalinized nodule (B area in A: hematoxylin-eosin stain: original magnification ×200) showed spindle-shaped neoplastic myoepithelial cells in the myxoid stroma, which showed the typical histology of pleomorphic adenoma. (C) Atypical ductal carcinoma in situ component (C area in A: hematoxylin-eosin stain: original magnification ×200) was observed in the peripheral portion of pleomorphic adenoma. (D) Invasive component (D area in A: hematoxylin-eosin stain: original magnification ×200) showed the diffuse growth of noncoherent, ovoid-shaped, carcinoma cells. (D: inset: hematoxylin-eosin stain: original magnification ×400) Carcinoma cells showed eccentric nuclei, marked cellular atypia and 1 large nucleolus with eosinophilic cytoplasm. (E) Typical histology of salivary duct carcinoma, which consisted of irregular-shaped atypical glands with eosinophilic cytoplasm, relatively large cytoplasm and marked nuclear atypia, was seen at the invasive component (E area in A: hematoxylin-eosin stain: original magnification ×200).
Mentions: Macroscopically, case 1 showed an ill-defined grayish-white mass in the left parotid gland. A whitish elastic-hard nodule was seen in this main mass (Figure 2A).

Bottom Line: This submandibular tumor was also composed of both residual pleomorphic adenoma region and invasive adenocarcinoma components, whereas some metastatic lesions were purely composed of rhabdoid cells.Such cells were strongly and diffusely positive for cytokeratins (CKs), gross cystic disease fluid protein-15 (GCDFP), and androgen receptor (AR).Case 1 was also positive for Her-2 and p53.

View Article: PubMed Central - PubMed

Affiliation: Pathology Division, Shizuoka Cancer Center, Shizuoka, Japan.

Show MeSH
Related in: MedlinePlus