Association of severe intrahepatic cholestasis of pregnancy with adverse pregnancy outcomes: a prospective population-based case-control study.
Bottom Line: These differences remained significant against national data.In the largest prospective cohort study in severe ICP to date, we demonstrate significant increased risks of adverse perinatal outcomes, including stillbirth.Our findings support the case for close antenatal monitoring of pregnancies affected by severe ICP.
Affiliation: Institute of Reproductive and Developmental Biology, Imperial College London, London, UK.Show MeSH
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Mentions: Women with severe ICP delivered earlier than controls (mean difference in gestational age −2.12 weeks; 95% CI −1.98 to −2.27) (Table 4). There was a significant increase in the number of spontaneous and iatrogenic preterm deliveries. The majority of preterm deliveries were iatrogenic, with 17% (114 women) in the ICP population compared to 2.7% (60 women) in the controls (unadjusted OR 7.39; 95% CI 5.33 to 10.25) being induced or delivered electively (Fig. 2; Supporting Table 4). The differences in rates of preterm delivery remained significant following correction of the data for potential confounding factors (maternal age, BMI, occupation, ethnicity, and parity).
Affiliation: Institute of Reproductive and Developmental Biology, Imperial College London, London, UK.