Limits...
Gadofosveset-based biomarker of tissue albumin concentration: Technical validation in vitro and feasibility in vivo.

Richardson OC, Bane O, Scott ML, Tanner SF, Waterton JC, Sourbron SP, Carroll TJ, Buckley DL - Magn Reson Med (2014)

Bottom Line: The mean calculated albumin concentration in the myocardium for the volunteers was 0.02 mM (range, 0.01-0.03 mM).In the myocardium the MRI-derived estimates of albumin concentration indicate the practical feasibility of the technique but were below expected values.Gadofosveset-enhanced MR relaxometry has potential in providing biomarkers of regional albumin concentration; further evaluation is required before it can be used reliably in vivo.

View Article: PubMed Central - PubMed

Affiliation: Division of Medical Physics, University of Leeds, Leeds, United Kingdom.

No MeSH data available.


ΔR1 (left column) and ΔR2 (right column) values for gadofosveset at a range of albumin concentrations and for gadopentetate at 0.7 mM, at 3.0T (upper row) and 4.7T (lower row). Points represent measured values (with 95% confidence intervals); gadofosveset lines represent model fit based on relaxivities in Table 2; gadopentetate lines represent linear fit.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
getmorefigures.php?uid=PMC4296221&req=5

fig02: ΔR1 (left column) and ΔR2 (right column) values for gadofosveset at a range of albumin concentrations and for gadopentetate at 0.7 mM, at 3.0T (upper row) and 4.7T (lower row). Points represent measured values (with 95% confidence intervals); gadofosveset lines represent model fit based on relaxivities in Table 2; gadopentetate lines represent linear fit.

Mentions: Figure 2 shows model fits (Eq. [14]) plotted against actual ΔR1 and ΔR2 gadofosveset data points at 3.0T and 4.7T, using the mean individual relaxivities in Table 2. A linear fit to the gadopentetate data is also shown.


Gadofosveset-based biomarker of tissue albumin concentration: Technical validation in vitro and feasibility in vivo.

Richardson OC, Bane O, Scott ML, Tanner SF, Waterton JC, Sourbron SP, Carroll TJ, Buckley DL - Magn Reson Med (2014)

ΔR1 (left column) and ΔR2 (right column) values for gadofosveset at a range of albumin concentrations and for gadopentetate at 0.7 mM, at 3.0T (upper row) and 4.7T (lower row). Points represent measured values (with 95% confidence intervals); gadofosveset lines represent model fit based on relaxivities in Table 2; gadopentetate lines represent linear fit.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4296221&req=5

fig02: ΔR1 (left column) and ΔR2 (right column) values for gadofosveset at a range of albumin concentrations and for gadopentetate at 0.7 mM, at 3.0T (upper row) and 4.7T (lower row). Points represent measured values (with 95% confidence intervals); gadofosveset lines represent model fit based on relaxivities in Table 2; gadopentetate lines represent linear fit.
Mentions: Figure 2 shows model fits (Eq. [14]) plotted against actual ΔR1 and ΔR2 gadofosveset data points at 3.0T and 4.7T, using the mean individual relaxivities in Table 2. A linear fit to the gadopentetate data is also shown.

Bottom Line: The mean calculated albumin concentration in the myocardium for the volunteers was 0.02 mM (range, 0.01-0.03 mM).In the myocardium the MRI-derived estimates of albumin concentration indicate the practical feasibility of the technique but were below expected values.Gadofosveset-enhanced MR relaxometry has potential in providing biomarkers of regional albumin concentration; further evaluation is required before it can be used reliably in vivo.

View Article: PubMed Central - PubMed

Affiliation: Division of Medical Physics, University of Leeds, Leeds, United Kingdom.

No MeSH data available.