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Gadofosveset-based biomarker of tissue albumin concentration: Technical validation in vitro and feasibility in vivo.

Richardson OC, Bane O, Scott ML, Tanner SF, Waterton JC, Sourbron SP, Carroll TJ, Buckley DL - Magn Reson Med (2014)

Bottom Line: The mean calculated albumin concentration in the myocardium for the volunteers was 0.02 mM (range, 0.01-0.03 mM).In the myocardium the MRI-derived estimates of albumin concentration indicate the practical feasibility of the technique but were below expected values.Gadofosveset-enhanced MR relaxometry has potential in providing biomarkers of regional albumin concentration; further evaluation is required before it can be used reliably in vivo.

View Article: PubMed Central - PubMed

Affiliation: Division of Medical Physics, University of Leeds, Leeds, United Kingdom.

No MeSH data available.


Modeled variation of ΔR2 with gadofosveset concentration for three serum albumin concentrations, based on Eq. [14], assuming values of Ka = 11.0 mM−1, r2bound = 60.0 s−1 mM−1, r2free = 6.1 s−1 mM−1 (29)
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fig01: Modeled variation of ΔR2 with gadofosveset concentration for three serum albumin concentrations, based on Eq. [14], assuming values of Ka = 11.0 mM−1, r2bound = 60.0 s−1 mM−1, r2free = 6.1 s−1 mM−1 (29)

Mentions: Only the negative form of the quadratic solution is applicable as the positive form would give a nonzero solution for Cgbound at Cg = 0. Eq. [14] has been represented in a similar form in several papers (for example, (30,32,33)). The model describes a gradual transition of binding fraction, from a maximum at low Cg, where observed relaxivity is dominated by r1,2bound, toward a minimum at high Cg, where r1,2free has the greater influence (Fig. 1). As the model assumes a single binding site, the shift in emphasis from r1,2bound to r1,2free occurs at around Cg = Csa.


Gadofosveset-based biomarker of tissue albumin concentration: Technical validation in vitro and feasibility in vivo.

Richardson OC, Bane O, Scott ML, Tanner SF, Waterton JC, Sourbron SP, Carroll TJ, Buckley DL - Magn Reson Med (2014)

Modeled variation of ΔR2 with gadofosveset concentration for three serum albumin concentrations, based on Eq. [14], assuming values of Ka = 11.0 mM−1, r2bound = 60.0 s−1 mM−1, r2free = 6.1 s−1 mM−1 (29)
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4296221&req=5

fig01: Modeled variation of ΔR2 with gadofosveset concentration for three serum albumin concentrations, based on Eq. [14], assuming values of Ka = 11.0 mM−1, r2bound = 60.0 s−1 mM−1, r2free = 6.1 s−1 mM−1 (29)
Mentions: Only the negative form of the quadratic solution is applicable as the positive form would give a nonzero solution for Cgbound at Cg = 0. Eq. [14] has been represented in a similar form in several papers (for example, (30,32,33)). The model describes a gradual transition of binding fraction, from a maximum at low Cg, where observed relaxivity is dominated by r1,2bound, toward a minimum at high Cg, where r1,2free has the greater influence (Fig. 1). As the model assumes a single binding site, the shift in emphasis from r1,2bound to r1,2free occurs at around Cg = Csa.

Bottom Line: The mean calculated albumin concentration in the myocardium for the volunteers was 0.02 mM (range, 0.01-0.03 mM).In the myocardium the MRI-derived estimates of albumin concentration indicate the practical feasibility of the technique but were below expected values.Gadofosveset-enhanced MR relaxometry has potential in providing biomarkers of regional albumin concentration; further evaluation is required before it can be used reliably in vivo.

View Article: PubMed Central - PubMed

Affiliation: Division of Medical Physics, University of Leeds, Leeds, United Kingdom.

No MeSH data available.