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Clinical value of serum eosinophilic cationic protein assessment in children with inflammatory bowel disease.

Wędrychowicz A, Tomasik P, Pieczarkowski S, Kowalska-Duplaga K, Grzenda-Adamek Z, Fyderek K - Arch Med Sci (2013)

Bottom Line: We found elevated ECP at baseline in the total active IBD group when compared to the inactive IBD and control groups, decreasing during treatment.Serum ECP was also elevated in the active UC and CD groups when compared to the inactive UC and CD groups, and correlated with clinical UC and CD activity (R = 0.57 and R = 0.52, p < 0.05, respectively) and duration of the clinical manifestation in UC (R = 0.62, p < 0.05) but not with the disease location in the gastrointestinal tract, or endoscopic and histopathological activity.Evaluation of serum ECP in children with IBD may be useful in disease activity assessment at onset and during the treatment.

View Article: PubMed Central - PubMed

Affiliation: Department of Pediatrics, Gastroenterology and Nutrition, Polish-American Children's Hospital, Jagiellonian University Medical College, Krakow, Poland.

ABSTRACT

Introduction: Eosinophils contribute to the pathogenesis of inflammatory bowel disease (IBD) in the intestine. Eosinophilic cationic protein (ECP) is one of the most important eosinophilic specific mediators released during activation. The aim of the study was to evaluate the clinical value of serum ECP determination in children with active and inactive IBD and its correlation with disease activity.

Material and methods: There were 125 children with IBD (63 with Crohn's disease - CD, 44 with ulcerative colitis - UC, 18 indeterminate colitis - IC) enrolled in the study. Among them 83 children were in the active phase of the disease, while the remaining 42 were in remission. The control group consisted of 56 healthy children. The ECP was assessed three times in children with active IBD, at baseline and after 2 and 6 weeks of treatment and once in children with inactive IBD and controls using fluoroenzymeimmunoassays.

Results: We found elevated ECP at baseline in the total active IBD group when compared to the inactive IBD and control groups, decreasing during treatment. Serum ECP was also elevated in the active UC and CD groups when compared to the inactive UC and CD groups, and correlated with clinical UC and CD activity (R = 0.57 and R = 0.52, p < 0.05, respectively) and duration of the clinical manifestation in UC (R = 0.62, p < 0.05) but not with the disease location in the gastrointestinal tract, or endoscopic and histopathological activity.

Conclusions: Evaluation of serum ECP in children with IBD may be useful in disease activity assessment at onset and during the treatment.

No MeSH data available.


Related in: MedlinePlus

Correlation of serum ECP concentrations with clinical activity in UC group
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Figure 0003: Correlation of serum ECP concentrations with clinical activity in UC group

Mentions: The serum ECP concentrations in the active UC and CD groups correlated with the clinical disease activity (R = 0.57 and R = 0.52, p < 0.05, respectively) (Figures 3 and 4). They also correlated with the values of erythrocyte sedimentation rate (ESR) (R = 0.60 and R = 0.44, p < 0.05, respectively) but did not correlate with C-reactive protein values and serological parameters (pANCA and ASCA) (Table II).


Clinical value of serum eosinophilic cationic protein assessment in children with inflammatory bowel disease.

Wędrychowicz A, Tomasik P, Pieczarkowski S, Kowalska-Duplaga K, Grzenda-Adamek Z, Fyderek K - Arch Med Sci (2013)

Correlation of serum ECP concentrations with clinical activity in UC group
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4296054&req=5

Figure 0003: Correlation of serum ECP concentrations with clinical activity in UC group
Mentions: The serum ECP concentrations in the active UC and CD groups correlated with the clinical disease activity (R = 0.57 and R = 0.52, p < 0.05, respectively) (Figures 3 and 4). They also correlated with the values of erythrocyte sedimentation rate (ESR) (R = 0.60 and R = 0.44, p < 0.05, respectively) but did not correlate with C-reactive protein values and serological parameters (pANCA and ASCA) (Table II).

Bottom Line: We found elevated ECP at baseline in the total active IBD group when compared to the inactive IBD and control groups, decreasing during treatment.Serum ECP was also elevated in the active UC and CD groups when compared to the inactive UC and CD groups, and correlated with clinical UC and CD activity (R = 0.57 and R = 0.52, p < 0.05, respectively) and duration of the clinical manifestation in UC (R = 0.62, p < 0.05) but not with the disease location in the gastrointestinal tract, or endoscopic and histopathological activity.Evaluation of serum ECP in children with IBD may be useful in disease activity assessment at onset and during the treatment.

View Article: PubMed Central - PubMed

Affiliation: Department of Pediatrics, Gastroenterology and Nutrition, Polish-American Children's Hospital, Jagiellonian University Medical College, Krakow, Poland.

ABSTRACT

Introduction: Eosinophils contribute to the pathogenesis of inflammatory bowel disease (IBD) in the intestine. Eosinophilic cationic protein (ECP) is one of the most important eosinophilic specific mediators released during activation. The aim of the study was to evaluate the clinical value of serum ECP determination in children with active and inactive IBD and its correlation with disease activity.

Material and methods: There were 125 children with IBD (63 with Crohn's disease - CD, 44 with ulcerative colitis - UC, 18 indeterminate colitis - IC) enrolled in the study. Among them 83 children were in the active phase of the disease, while the remaining 42 were in remission. The control group consisted of 56 healthy children. The ECP was assessed three times in children with active IBD, at baseline and after 2 and 6 weeks of treatment and once in children with inactive IBD and controls using fluoroenzymeimmunoassays.

Results: We found elevated ECP at baseline in the total active IBD group when compared to the inactive IBD and control groups, decreasing during treatment. Serum ECP was also elevated in the active UC and CD groups when compared to the inactive UC and CD groups, and correlated with clinical UC and CD activity (R = 0.57 and R = 0.52, p < 0.05, respectively) and duration of the clinical manifestation in UC (R = 0.62, p < 0.05) but not with the disease location in the gastrointestinal tract, or endoscopic and histopathological activity.

Conclusions: Evaluation of serum ECP in children with IBD may be useful in disease activity assessment at onset and during the treatment.

No MeSH data available.


Related in: MedlinePlus