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Alcohol-induced Hyperlipidemia Is Ameliorated by Orally Administered DWP208, a Sodium Succinate Form of ZYM201.

Cho JY, Choi J, Park JG, Yi YS, Hossen MJ, Kim H, Ro J, Cha BC, Yoo ES, Kim JH, Lee J - Korean J. Physiol. Pharmacol. (2014)

Bottom Line: DWP208 is a sodium succinate form of ZYM-201 which is a triterpenoid glycoside isolated from Sanguisorba officinalis, a medicinal plant prescribed for various diseases, such as duodenal ulcers and bleeding in East Asian counties.In this study, we determined whether hyperlipidemic conditions induced with chronically treated alcohol can also be restored by DWP208.According to our data, the ameliorative activity of DWP208 is due to its indirect anti-oxidative activity as a result of which lipid peroxide and hydroxyl radical levels were reduced and the activity of SOD was enhanced.

View Article: PubMed Central - PubMed

Affiliation: Department of Genetic Engineering, Sungkyunkwan University, Suwon 440-746, Korea.

ABSTRACT
DWP208 is a sodium succinate form of ZYM-201 which is a triterpenoid glycoside isolated from Sanguisorba officinalis, a medicinal plant prescribed for various diseases, such as duodenal ulcers and bleeding in East Asian counties. We demonstrated that this compound is able to normalize the altered lipid metabolism induced by hyperglycemia and a high fat diet. In this study, we determined whether hyperlipidemic conditions induced with chronically treated alcohol can also be restored by DWP208. Similar to our previous results, orally administered DWP208 (1 to 10 mg/kg) also ameliorated the hyperlipidemia that was induced by alcohol. This compound reversed the alcohol-induced hyperlipidemia including (i) up-regulated hyperlipidemic parameters such as low-density lipoprotein (LDL), very low-density lipoprotein (VLDL), atherosclerotic index (AI), triglyceride, and total cholesterol, and (ii) down-regulated hyperlipidemic parameters such as absolute body weight, superoxide dismutase (SOD) activity, and high-density lipoprotein (HDL) in serum and liver. According to our data, the ameliorative activity of DWP208 is due to its indirect anti-oxidative activity as a result of which lipid peroxide and hydroxyl radical levels were reduced and the activity of SOD was enhanced. Therefore, our data strongly suggest that DWP208 can be used as a remedy against alcohol-induced hyperlipidemia.

No MeSH data available.


Related in: MedlinePlus

Effect of DWP208 on serum parameters in alcohol-induced hyperlipidemic rats. (A) Alcohol-treated rats were orally administered with DWP208 or fenofibrate (Feno) for 1 week. After preparing serum from rats, levels of triglyceride were examined. (B) Lipase activity in serum was determined. Data represent mean±SEM of four independent observations performed with 10 rats. #p<0.05 compared to normal group, *p<0.05 and **p<0.01 compared to control group.
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Figure 3: Effect of DWP208 on serum parameters in alcohol-induced hyperlipidemic rats. (A) Alcohol-treated rats were orally administered with DWP208 or fenofibrate (Feno) for 1 week. After preparing serum from rats, levels of triglyceride were examined. (B) Lipase activity in serum was determined. Data represent mean±SEM of four independent observations performed with 10 rats. #p<0.05 compared to normal group, *p<0.05 and **p<0.01 compared to control group.

Mentions: During chronic alcohol (10%) treatment, it has been shown that liver function and lipid metabolism are altered. Thus, alcohol treated individuals display striking hyperlipidemic symptoms such as (i) up-regulated levels of LDL, VLDL, atherosclerosis index (AI), serum triglyceride and total cholesterol, hepatic total lipid, cholesterol, and triglyceride levels, and serum lipoproteins and HMG-CoA reductase contents (Fig. 2, 3, 4, 5, Table 1), and (ii) down-regulated levels of body weight, HDL, and SOD activity (Table 2, Fig. 2A, and Fig. 5C). The alcohol-induced up-regulation and down-regulation of these parameters were previously reported [21,22], indicating that our experimental plan was feasible.


Alcohol-induced Hyperlipidemia Is Ameliorated by Orally Administered DWP208, a Sodium Succinate Form of ZYM201.

Cho JY, Choi J, Park JG, Yi YS, Hossen MJ, Kim H, Ro J, Cha BC, Yoo ES, Kim JH, Lee J - Korean J. Physiol. Pharmacol. (2014)

Effect of DWP208 on serum parameters in alcohol-induced hyperlipidemic rats. (A) Alcohol-treated rats were orally administered with DWP208 or fenofibrate (Feno) for 1 week. After preparing serum from rats, levels of triglyceride were examined. (B) Lipase activity in serum was determined. Data represent mean±SEM of four independent observations performed with 10 rats. #p<0.05 compared to normal group, *p<0.05 and **p<0.01 compared to control group.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4296035&req=5

Figure 3: Effect of DWP208 on serum parameters in alcohol-induced hyperlipidemic rats. (A) Alcohol-treated rats were orally administered with DWP208 or fenofibrate (Feno) for 1 week. After preparing serum from rats, levels of triglyceride were examined. (B) Lipase activity in serum was determined. Data represent mean±SEM of four independent observations performed with 10 rats. #p<0.05 compared to normal group, *p<0.05 and **p<0.01 compared to control group.
Mentions: During chronic alcohol (10%) treatment, it has been shown that liver function and lipid metabolism are altered. Thus, alcohol treated individuals display striking hyperlipidemic symptoms such as (i) up-regulated levels of LDL, VLDL, atherosclerosis index (AI), serum triglyceride and total cholesterol, hepatic total lipid, cholesterol, and triglyceride levels, and serum lipoproteins and HMG-CoA reductase contents (Fig. 2, 3, 4, 5, Table 1), and (ii) down-regulated levels of body weight, HDL, and SOD activity (Table 2, Fig. 2A, and Fig. 5C). The alcohol-induced up-regulation and down-regulation of these parameters were previously reported [21,22], indicating that our experimental plan was feasible.

Bottom Line: DWP208 is a sodium succinate form of ZYM-201 which is a triterpenoid glycoside isolated from Sanguisorba officinalis, a medicinal plant prescribed for various diseases, such as duodenal ulcers and bleeding in East Asian counties.In this study, we determined whether hyperlipidemic conditions induced with chronically treated alcohol can also be restored by DWP208.According to our data, the ameliorative activity of DWP208 is due to its indirect anti-oxidative activity as a result of which lipid peroxide and hydroxyl radical levels were reduced and the activity of SOD was enhanced.

View Article: PubMed Central - PubMed

Affiliation: Department of Genetic Engineering, Sungkyunkwan University, Suwon 440-746, Korea.

ABSTRACT
DWP208 is a sodium succinate form of ZYM-201 which is a triterpenoid glycoside isolated from Sanguisorba officinalis, a medicinal plant prescribed for various diseases, such as duodenal ulcers and bleeding in East Asian counties. We demonstrated that this compound is able to normalize the altered lipid metabolism induced by hyperglycemia and a high fat diet. In this study, we determined whether hyperlipidemic conditions induced with chronically treated alcohol can also be restored by DWP208. Similar to our previous results, orally administered DWP208 (1 to 10 mg/kg) also ameliorated the hyperlipidemia that was induced by alcohol. This compound reversed the alcohol-induced hyperlipidemia including (i) up-regulated hyperlipidemic parameters such as low-density lipoprotein (LDL), very low-density lipoprotein (VLDL), atherosclerotic index (AI), triglyceride, and total cholesterol, and (ii) down-regulated hyperlipidemic parameters such as absolute body weight, superoxide dismutase (SOD) activity, and high-density lipoprotein (HDL) in serum and liver. According to our data, the ameliorative activity of DWP208 is due to its indirect anti-oxidative activity as a result of which lipid peroxide and hydroxyl radical levels were reduced and the activity of SOD was enhanced. Therefore, our data strongly suggest that DWP208 can be used as a remedy against alcohol-induced hyperlipidemia.

No MeSH data available.


Related in: MedlinePlus