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The effect of intrathecal curcumin on mechanical allodynia in rats after L5 spinal nerve ligation.

Lee JH, Kim YD, Jung HC, Cheong YK - Korean J Anesthesiol (2014)

View Article: PubMed Central - PubMed

Affiliation: Department of Anesthesiology and Pain Medicine, Wonkwang University School of Medicine, Iksan, Korea.

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Curcumin is found in the yellow spice turmeric made from the roots (rhizomes) of Curcuma longa... This research was designed to examine whether the intrathecal injection of curcumin exerts an alleviating effect on mechanical allodynia in the rat spinal nerve ligation (SNL) model... Group 1, the sham-operated group, showed no change in ipsilateral PWTs... In contrast, groups 2 and 3, which had undergone SNL, showed a statistically significant decrease in ipsilateral PWTs compared to group 1 (P < 0.05)... When group 2 was compared with group 3, there was no statistically significant difference in ipsilateral PWTs on the 7th, 8th, and 9th day after SNL... Intrathecally delivered recombinant TNF-α induced mechanical allodynia and thermal hyperalgesia in rats; while intrathecally administered etanercept, a TNF-α inhibitor, could alleviate inflammatory pain... In addition, spinal synaptic plasticity could be effectively regulated by the interaction between TNF-α and transient receptor potential subtype V1... In the present research, groups 3 showed no significant change in PWTs on the 7th day through the 9th day after SNL in spite of curcumin injection compared to group 2, but only from the 10th day, group 3 showed a significant change in PWTs compared to group 2... The reason for this occurrence could not be ascertained... However, Zhu et el. reported that significant anti-nociceptive effect could be observed after at least 5 days of daily curcumin administration during the time courses of thermal latency and mechanical threshold... Zhao et el. reported that the levels of spinal monoamine (serotonin) and metabolite (3-methoxy-4-hydroxyphenylglycol, MHPG) were elevated by chronic curcumin treatment, while the modality-specific analgesic effect of curcumin disappeared completely after spinal noradrenaline or serotonin transmission was interrupted... According to a research conducted by Han et al. using a rat model that was created to show biphasic flinching response by the subcutaneous injection of formalin into the hind paw, intrathecal administration of curcumin resulted in reduction in the number of flinching responses in both phase 1 and phase 2... In conclusion, this research demonstrated the alleviating effect of intrathecally administered curcumin on mechanical allodynia in nerve-injured rats, and an additional research is necessary for assessing the spinal mechanism of action of curcumin.

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The alleviating effect of intrathecally injected curcumin on mechanical allodynia in nerve-injured rats. Group 1 (n = 5) is the shamoperated group, group 2 (n = 5) is the SNL group, and group 3 (n = 5) is the SNL with curcumin group. Groups 2 and 3 showed a statistically significant decrease in ipsilateral PWTs compared to group 1. Group 3 showed statistically significant increases in ipsilateral PWTs than group 2 on the 10th, 15th, and 20th day after surgery. *P < 0.05 compared to Group 1, †P < 0.05 compared to Group 2. SNL: spinal nerve ligation, PWTs: paw withdrawal thresholds.
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Figure 1: The alleviating effect of intrathecally injected curcumin on mechanical allodynia in nerve-injured rats. Group 1 (n = 5) is the shamoperated group, group 2 (n = 5) is the SNL group, and group 3 (n = 5) is the SNL with curcumin group. Groups 2 and 3 showed a statistically significant decrease in ipsilateral PWTs compared to group 1. Group 3 showed statistically significant increases in ipsilateral PWTs than group 2 on the 10th, 15th, and 20th day after surgery. *P < 0.05 compared to Group 1, †P < 0.05 compared to Group 2. SNL: spinal nerve ligation, PWTs: paw withdrawal thresholds.

Mentions: Group 1, the sham-operated group, showed no change in ipsilateral PWTs. In contrast, groups 2 and 3, which had undergone SNL, showed a statistically significant decrease in ipsilateral PWTs compared to group 1 (P < 0.05). When group 2 was compared with group 3, there was no statistically significant difference in ipsilateral PWTs on the 7th, 8th, and 9th day after SNL. On the 10th, 15th, and 20th day after SNL, however, group 3 showed statistically significantly higher ipsilateral PWTs than group 2 (P < 0.05) (Fig. 1).


The effect of intrathecal curcumin on mechanical allodynia in rats after L5 spinal nerve ligation.

Lee JH, Kim YD, Jung HC, Cheong YK - Korean J Anesthesiol (2014)

The alleviating effect of intrathecally injected curcumin on mechanical allodynia in nerve-injured rats. Group 1 (n = 5) is the shamoperated group, group 2 (n = 5) is the SNL group, and group 3 (n = 5) is the SNL with curcumin group. Groups 2 and 3 showed a statistically significant decrease in ipsilateral PWTs compared to group 1. Group 3 showed statistically significant increases in ipsilateral PWTs than group 2 on the 10th, 15th, and 20th day after surgery. *P < 0.05 compared to Group 1, †P < 0.05 compared to Group 2. SNL: spinal nerve ligation, PWTs: paw withdrawal thresholds.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4295958&req=5

Figure 1: The alleviating effect of intrathecally injected curcumin on mechanical allodynia in nerve-injured rats. Group 1 (n = 5) is the shamoperated group, group 2 (n = 5) is the SNL group, and group 3 (n = 5) is the SNL with curcumin group. Groups 2 and 3 showed a statistically significant decrease in ipsilateral PWTs compared to group 1. Group 3 showed statistically significant increases in ipsilateral PWTs than group 2 on the 10th, 15th, and 20th day after surgery. *P < 0.05 compared to Group 1, †P < 0.05 compared to Group 2. SNL: spinal nerve ligation, PWTs: paw withdrawal thresholds.
Mentions: Group 1, the sham-operated group, showed no change in ipsilateral PWTs. In contrast, groups 2 and 3, which had undergone SNL, showed a statistically significant decrease in ipsilateral PWTs compared to group 1 (P < 0.05). When group 2 was compared with group 3, there was no statistically significant difference in ipsilateral PWTs on the 7th, 8th, and 9th day after SNL. On the 10th, 15th, and 20th day after SNL, however, group 3 showed statistically significantly higher ipsilateral PWTs than group 2 (P < 0.05) (Fig. 1).

View Article: PubMed Central - PubMed

Affiliation: Department of Anesthesiology and Pain Medicine, Wonkwang University School of Medicine, Iksan, Korea.

AUTOMATICALLY GENERATED EXCERPT
Please rate it.

Curcumin is found in the yellow spice turmeric made from the roots (rhizomes) of Curcuma longa... This research was designed to examine whether the intrathecal injection of curcumin exerts an alleviating effect on mechanical allodynia in the rat spinal nerve ligation (SNL) model... Group 1, the sham-operated group, showed no change in ipsilateral PWTs... In contrast, groups 2 and 3, which had undergone SNL, showed a statistically significant decrease in ipsilateral PWTs compared to group 1 (P < 0.05)... When group 2 was compared with group 3, there was no statistically significant difference in ipsilateral PWTs on the 7th, 8th, and 9th day after SNL... Intrathecally delivered recombinant TNF-α induced mechanical allodynia and thermal hyperalgesia in rats; while intrathecally administered etanercept, a TNF-α inhibitor, could alleviate inflammatory pain... In addition, spinal synaptic plasticity could be effectively regulated by the interaction between TNF-α and transient receptor potential subtype V1... In the present research, groups 3 showed no significant change in PWTs on the 7th day through the 9th day after SNL in spite of curcumin injection compared to group 2, but only from the 10th day, group 3 showed a significant change in PWTs compared to group 2... The reason for this occurrence could not be ascertained... However, Zhu et el. reported that significant anti-nociceptive effect could be observed after at least 5 days of daily curcumin administration during the time courses of thermal latency and mechanical threshold... Zhao et el. reported that the levels of spinal monoamine (serotonin) and metabolite (3-methoxy-4-hydroxyphenylglycol, MHPG) were elevated by chronic curcumin treatment, while the modality-specific analgesic effect of curcumin disappeared completely after spinal noradrenaline or serotonin transmission was interrupted... According to a research conducted by Han et al. using a rat model that was created to show biphasic flinching response by the subcutaneous injection of formalin into the hind paw, intrathecal administration of curcumin resulted in reduction in the number of flinching responses in both phase 1 and phase 2... In conclusion, this research demonstrated the alleviating effect of intrathecally administered curcumin on mechanical allodynia in nerve-injured rats, and an additional research is necessary for assessing the spinal mechanism of action of curcumin.

No MeSH data available.


Related in: MedlinePlus