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Association of the neutrophil-to-lymphocyte ratio and CA 125 with the endometriosis score.

Kim SK, Park JY, Jee BC, Suh CS, Kim SH - Clin Exp Reprod Med (2014)

Bottom Line: The endometriosis score was negatively related to preoperative hemoglobin, hematocrit, mean corpuscular volume, mean corpuscular hemoglobin, and mean corpuscular hemoglobin concentration.The only positive association was between NLR and the patients' age.NLR and preoperative serum anti-Müllerian hormone level were found to be negatively related.

View Article: PubMed Central - PubMed

Affiliation: Department of Obstetrics and Gynecology, Seoul National University Bundang Hospital, Seongnam, Korea. ; Department of Obstetrics and Gynecology, Seoul National University College of Medicine, Seoul, Korea.

ABSTRACT

Objective: To evaluate the association between the severity of endometriosis and the preoperative neutrophil-to-lymphocyte ratio (NLR) and serum level of cancer antigen 125 (CA 125).

Methods: Data were obtained from the medical records of 419 patients who underwent laparoscopic conservative surgery for ovarian endometrioma between April 2005 and March 2013. Each patient's preoperative complete blood count was recorded and the endometriosis score was assessed.

Results: The endometriosis score was not associated with either the NLR or the serum level of CA 125. The endometriosis score was negatively related to preoperative hemoglobin, hematocrit, mean corpuscular volume, mean corpuscular hemoglobin, and mean corpuscular hemoglobin concentration. The only positive association was between NLR and the patients' age. NLR and preoperative serum anti-Müllerian hormone level were found to be negatively related.

Conclusion: The severity of endometriosis was not associated with the serum level of CA 125 or the NLR. The presence of a negative correlation between the severity of endometriosis and red blood cell dynamics needs further investigation.

No MeSH data available.


Related in: MedlinePlus

Relationships between the endometriosis score and the preoperative values of the neutrophil-to-lymphocyte ratio (NLR) and cancer antigen (CA) 125. (A) NLR, no correlation (r=0.02, p=0.711) and (B) CA 125, no correlation (r=0.13, p=0.053).
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Figure 1: Relationships between the endometriosis score and the preoperative values of the neutrophil-to-lymphocyte ratio (NLR) and cancer antigen (CA) 125. (A) NLR, no correlation (r=0.02, p=0.711) and (B) CA 125, no correlation (r=0.13, p=0.053).

Mentions: Using the endometriosis score from the 419 women, linear relationships were assessed (Table 2). The endometriosis score had no association with either the NLR or the serum level of CA 125 (Figure 1). The endometriosis score had a significant negative relationship with the preoperative values of hemoglobin, hematocrit, mean corpuscular volume (MCV), mean corpuscular hemoglobin (MCH), and mean corpuscular hemoglobin concentration (MCHC), but a positive relationship with red cell distribution width (RDW). These findings were unexpected (Figure 2). No relationship between the endometriosis score and monocyte was observed in the linear analysis; however, a quadratic analysis revealed a significant negative correlation (r =-0.13, p=0.021) (Figure 3A).


Association of the neutrophil-to-lymphocyte ratio and CA 125 with the endometriosis score.

Kim SK, Park JY, Jee BC, Suh CS, Kim SH - Clin Exp Reprod Med (2014)

Relationships between the endometriosis score and the preoperative values of the neutrophil-to-lymphocyte ratio (NLR) and cancer antigen (CA) 125. (A) NLR, no correlation (r=0.02, p=0.711) and (B) CA 125, no correlation (r=0.13, p=0.053).
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4295941&req=5

Figure 1: Relationships between the endometriosis score and the preoperative values of the neutrophil-to-lymphocyte ratio (NLR) and cancer antigen (CA) 125. (A) NLR, no correlation (r=0.02, p=0.711) and (B) CA 125, no correlation (r=0.13, p=0.053).
Mentions: Using the endometriosis score from the 419 women, linear relationships were assessed (Table 2). The endometriosis score had no association with either the NLR or the serum level of CA 125 (Figure 1). The endometriosis score had a significant negative relationship with the preoperative values of hemoglobin, hematocrit, mean corpuscular volume (MCV), mean corpuscular hemoglobin (MCH), and mean corpuscular hemoglobin concentration (MCHC), but a positive relationship with red cell distribution width (RDW). These findings were unexpected (Figure 2). No relationship between the endometriosis score and monocyte was observed in the linear analysis; however, a quadratic analysis revealed a significant negative correlation (r =-0.13, p=0.021) (Figure 3A).

Bottom Line: The endometriosis score was negatively related to preoperative hemoglobin, hematocrit, mean corpuscular volume, mean corpuscular hemoglobin, and mean corpuscular hemoglobin concentration.The only positive association was between NLR and the patients' age.NLR and preoperative serum anti-Müllerian hormone level were found to be negatively related.

View Article: PubMed Central - PubMed

Affiliation: Department of Obstetrics and Gynecology, Seoul National University Bundang Hospital, Seongnam, Korea. ; Department of Obstetrics and Gynecology, Seoul National University College of Medicine, Seoul, Korea.

ABSTRACT

Objective: To evaluate the association between the severity of endometriosis and the preoperative neutrophil-to-lymphocyte ratio (NLR) and serum level of cancer antigen 125 (CA 125).

Methods: Data were obtained from the medical records of 419 patients who underwent laparoscopic conservative surgery for ovarian endometrioma between April 2005 and March 2013. Each patient's preoperative complete blood count was recorded and the endometriosis score was assessed.

Results: The endometriosis score was not associated with either the NLR or the serum level of CA 125. The endometriosis score was negatively related to preoperative hemoglobin, hematocrit, mean corpuscular volume, mean corpuscular hemoglobin, and mean corpuscular hemoglobin concentration. The only positive association was between NLR and the patients' age. NLR and preoperative serum anti-Müllerian hormone level were found to be negatively related.

Conclusion: The severity of endometriosis was not associated with the serum level of CA 125 or the NLR. The presence of a negative correlation between the severity of endometriosis and red blood cell dynamics needs further investigation.

No MeSH data available.


Related in: MedlinePlus