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A biomechanical characterisation of acellular porcine super flexor tendons for use in anterior cruciate ligament replacement: investigation into the effects of fat reduction and bioburden reduction bioprocesses.

Herbert A, Jones GL, Ingham E, Fisher J - J Biomech (2014)

Bottom Line: The most effective of these was then carried forward into Study 2, which investigated the use of antibiotics or peracetic acid (PAA) as a bioburden reduction agent.The most severe deviations from the profile of the native tangent modulus were found to occur in Study 2 when PAA was used for bioburden reduction.Acetone was chosen as the fat reduction step whereas, antibiotics was preferable over PAA as a bioburden reduction step.

View Article: PubMed Central - PubMed

Affiliation: (IMBE) Institute of Medical and Biological Engineering, School of Mechanical Engineering University of Leeds, Leeds, UK. Electronic address: A.Herbert@leeds.ac.uk.

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The experimental stress–strain data was fitted to a 3rd order Gaussian function from which the first and second derivatives were calculated. The first location at which the second derivative was zero was interpreted as the transition point from the toe-region into the linear-region. The third location at which the second derivative was zero was interpreted to mark the end of the linear-region.
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f0015: The experimental stress–strain data was fitted to a 3rd order Gaussian function from which the first and second derivatives were calculated. The first location at which the second derivative was zero was interpreted as the transition point from the toe-region into the linear-region. The third location at which the second derivative was zero was interpreted to mark the end of the linear-region.

Mentions: This was differentiated twice and the locations at which the 2nd order differential was found to be zero were determined. The first of these was interpreted to mark the transition from the toe-region of the curve into the linear-region and the third marked the end of the linear-region. The corresponding strain values for these points were noted and used to distinguish between the experimental data for the toe-region and the linear-region (indicated with arrows in Fig. 3). The transition point between both regions (εT, σT) comprised of the transition strain (εT) and transition stress (σT).


A biomechanical characterisation of acellular porcine super flexor tendons for use in anterior cruciate ligament replacement: investigation into the effects of fat reduction and bioburden reduction bioprocesses.

Herbert A, Jones GL, Ingham E, Fisher J - J Biomech (2014)

The experimental stress–strain data was fitted to a 3rd order Gaussian function from which the first and second derivatives were calculated. The first location at which the second derivative was zero was interpreted as the transition point from the toe-region into the linear-region. The third location at which the second derivative was zero was interpreted to mark the end of the linear-region.
© Copyright Policy - CC BY
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4295818&req=5

f0015: The experimental stress–strain data was fitted to a 3rd order Gaussian function from which the first and second derivatives were calculated. The first location at which the second derivative was zero was interpreted as the transition point from the toe-region into the linear-region. The third location at which the second derivative was zero was interpreted to mark the end of the linear-region.
Mentions: This was differentiated twice and the locations at which the 2nd order differential was found to be zero were determined. The first of these was interpreted to mark the transition from the toe-region of the curve into the linear-region and the third marked the end of the linear-region. The corresponding strain values for these points were noted and used to distinguish between the experimental data for the toe-region and the linear-region (indicated with arrows in Fig. 3). The transition point between both regions (εT, σT) comprised of the transition strain (εT) and transition stress (σT).

Bottom Line: The most effective of these was then carried forward into Study 2, which investigated the use of antibiotics or peracetic acid (PAA) as a bioburden reduction agent.The most severe deviations from the profile of the native tangent modulus were found to occur in Study 2 when PAA was used for bioburden reduction.Acetone was chosen as the fat reduction step whereas, antibiotics was preferable over PAA as a bioburden reduction step.

View Article: PubMed Central - PubMed

Affiliation: (IMBE) Institute of Medical and Biological Engineering, School of Mechanical Engineering University of Leeds, Leeds, UK. Electronic address: A.Herbert@leeds.ac.uk.

Show MeSH