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A biomechanical characterisation of acellular porcine super flexor tendons for use in anterior cruciate ligament replacement: investigation into the effects of fat reduction and bioburden reduction bioprocesses.

Herbert A, Jones GL, Ingham E, Fisher J - J Biomech (2014)

Bottom Line: The most effective of these was then carried forward into Study 2, which investigated the use of antibiotics or peracetic acid (PAA) as a bioburden reduction agent.The most severe deviations from the profile of the native tangent modulus were found to occur in Study 2 when PAA was used for bioburden reduction.Acetone was chosen as the fat reduction step whereas, antibiotics was preferable over PAA as a bioburden reduction step.

View Article: PubMed Central - PubMed

Affiliation: (IMBE) Institute of Medical and Biological Engineering, School of Mechanical Engineering University of Leeds, Leeds, UK. Electronic address: A.Herbert@leeds.ac.uk.

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(a) Study 1: the inclusion of acetone or chloroform–methanol as a fat reduction step, (b) Study 2: the inclusion of peracetic acid or antibiotics as a bio-burden reduction step and how these performed with/without peracetic acid as a terminal sterilant.
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f0005: (a) Study 1: the inclusion of acetone or chloroform–methanol as a fat reduction step, (b) Study 2: the inclusion of peracetic acid or antibiotics as a bio-burden reduction step and how these performed with/without peracetic acid as a terminal sterilant.

Mentions: The steps investigated and the processes involved are shown in Fig. 1(a).


A biomechanical characterisation of acellular porcine super flexor tendons for use in anterior cruciate ligament replacement: investigation into the effects of fat reduction and bioburden reduction bioprocesses.

Herbert A, Jones GL, Ingham E, Fisher J - J Biomech (2014)

(a) Study 1: the inclusion of acetone or chloroform–methanol as a fat reduction step, (b) Study 2: the inclusion of peracetic acid or antibiotics as a bio-burden reduction step and how these performed with/without peracetic acid as a terminal sterilant.
© Copyright Policy - CC BY
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4295818&req=5

f0005: (a) Study 1: the inclusion of acetone or chloroform–methanol as a fat reduction step, (b) Study 2: the inclusion of peracetic acid or antibiotics as a bio-burden reduction step and how these performed with/without peracetic acid as a terminal sterilant.
Mentions: The steps investigated and the processes involved are shown in Fig. 1(a).

Bottom Line: The most effective of these was then carried forward into Study 2, which investigated the use of antibiotics or peracetic acid (PAA) as a bioburden reduction agent.The most severe deviations from the profile of the native tangent modulus were found to occur in Study 2 when PAA was used for bioburden reduction.Acetone was chosen as the fat reduction step whereas, antibiotics was preferable over PAA as a bioburden reduction step.

View Article: PubMed Central - PubMed

Affiliation: (IMBE) Institute of Medical and Biological Engineering, School of Mechanical Engineering University of Leeds, Leeds, UK. Electronic address: A.Herbert@leeds.ac.uk.

Show MeSH