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MicroRNA-in drug resistance.

Li H, Yang BB - Oncoscience (2014)

View Article: PubMed Central - PubMed

Affiliation: Sunnybrook Research Institute, Sunnybrook Health Sciences Centre, Toronto, and Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto.

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For example, it has been estimated that over 80% of patients diagnosed with CRC after 2010 received chemotherapy... Despite considerable success however, resistance to chemotherapeutic treatment has emerged as an obstacle to effective treatment... Currently, several laboratories are exploring how microRNAs manipulate drug resistance to cause CRC tumor relapse through epigenetic modulations... Recent research from our lab, published in Oncotarget (Fang et al., Oncotarget, 2014, Advance Publications), uncovered the underlying mechanism responsible for acquired drug resistance and distant metastasis in CRC patients... We found that high levels of miR-17 expression was closely correlated with worsened long-term survival in 81 patients receiving chemotherapy (5.26 vs. 7.29 yrs)... Less drug-induced apoptosis was noted in CRC cells which highly expressed miR-17... In addition, knocking down miR-17 by antisense oligo was found to sensitize cells to cytotoxic agents' treatment... There is now growing evidence that miR-17 plays a key role in determining the prognosis of colorectal cancer... Yu and colleagues reported that high miR-17 expression was associated with reduced overall survival in 96 colon cancer patients... To further reveal the crosstalk between the microRNA network and tumor microenvironment, we generated stably transfected cell lines and showed temporal changes in miR-17 expression in CRC cells exposed to chemotherapy... With extensive investigation, PTEN/PI3K/AKT/HIF-1alpha cascade has been shown as one of the most crucial pathways which are responsible for therapy response and oxidative stress... Therefore, it is with great value to decipher how epigenetic alterations of PTEN pathway can result in chemotherapeutic drug resistance... Given its inherent genomic instability, CRC is able to maintain growth and proliferation through cross-talk between several signaling pathways... This level of complexity makes it more challenging to successfully treat patients.

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the proposed functions of microRNA in regulation of chemotherapy resistance
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Figure 1: the proposed functions of microRNA in regulation of chemotherapy resistance


MicroRNA-in drug resistance.

Li H, Yang BB - Oncoscience (2014)

the proposed functions of microRNA in regulation of chemotherapy resistance
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4295755&req=5

Figure 1: the proposed functions of microRNA in regulation of chemotherapy resistance

View Article: PubMed Central - PubMed

Affiliation: Sunnybrook Research Institute, Sunnybrook Health Sciences Centre, Toronto, and Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto.

AUTOMATICALLY GENERATED EXCERPT
Please rate it.

For example, it has been estimated that over 80% of patients diagnosed with CRC after 2010 received chemotherapy... Despite considerable success however, resistance to chemotherapeutic treatment has emerged as an obstacle to effective treatment... Currently, several laboratories are exploring how microRNAs manipulate drug resistance to cause CRC tumor relapse through epigenetic modulations... Recent research from our lab, published in Oncotarget (Fang et al., Oncotarget, 2014, Advance Publications), uncovered the underlying mechanism responsible for acquired drug resistance and distant metastasis in CRC patients... We found that high levels of miR-17 expression was closely correlated with worsened long-term survival in 81 patients receiving chemotherapy (5.26 vs. 7.29 yrs)... Less drug-induced apoptosis was noted in CRC cells which highly expressed miR-17... In addition, knocking down miR-17 by antisense oligo was found to sensitize cells to cytotoxic agents' treatment... There is now growing evidence that miR-17 plays a key role in determining the prognosis of colorectal cancer... Yu and colleagues reported that high miR-17 expression was associated with reduced overall survival in 96 colon cancer patients... To further reveal the crosstalk between the microRNA network and tumor microenvironment, we generated stably transfected cell lines and showed temporal changes in miR-17 expression in CRC cells exposed to chemotherapy... With extensive investigation, PTEN/PI3K/AKT/HIF-1alpha cascade has been shown as one of the most crucial pathways which are responsible for therapy response and oxidative stress... Therefore, it is with great value to decipher how epigenetic alterations of PTEN pathway can result in chemotherapeutic drug resistance... Given its inherent genomic instability, CRC is able to maintain growth and proliferation through cross-talk between several signaling pathways... This level of complexity makes it more challenging to successfully treat patients.

No MeSH data available.