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Serum matrix metalloproteinase-9 levels and severity of symptoms in boys with attention deficit hyperactivity disorder ADHD/hyperkinetic disorder HKD.

Kadziela-Olech H, Cichocki P, Chwiesko J, Konstantynowicz J, Braszko JJ - Eur Child Adolesc Psychiatry (2014)

Bottom Line: The serum levels of matrix metalloproteinase-9 (MMP-9) in neuropsychiatric disorders of adults have been widely investigated.Intellectual functions were measured using Wechsler Intelligence Scale for Children-Revised.According to the results, elevated levels of serum MMP-9 in boys with HKD may be associated with clinical impulsivity domain (β = 0.38; p = 0.019).

View Article: PubMed Central - PubMed

Affiliation: Medical University, Bialystok, Podlaskie, Poland, halina.kadziela-olech@umb.edu.pl.

ABSTRACT
The serum levels of matrix metalloproteinase-9 (MMP-9) in neuropsychiatric disorders of adults have been widely investigated. So far, no studies have been conducted on the relationship of MMP-9 and cognitive domains in children with two phenotype models, attention deficit/hyperactivity disorder and hyperkinetic disorder (ADHD/HKD). The aim of this research was to evaluate and test the hypothesis that serum MMP-9 levels are associated with the severity of symptoms in children with ADHD/HKD and to compare the results in two models of this disorder. The study group comprised 37 Caucasian boys aged 7-12 years with HKD, being a subset of the combined ADHD subtype. Intellectual functions were measured using Wechsler Intelligence Scale for Children-Revised. The analysis of serum concentrations of MMP-9 was based on a quantitative sandwich ELISA. The statistical regression analysis revealed a correlation between increased serum MMP-9 levels and severity of symptoms in the ADHD (β = 0.33; p = 0.043) and HKD (β = 0.34, p = 0.037) model. According to the results, elevated levels of serum MMP-9 in boys with HKD may be associated with clinical impulsivity domain (β = 0.38; p = 0.019).

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Related in: MedlinePlus

The symptom severity and MMP-9 levels in boys with HKD/ADHD
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Related In: Results  -  Collection


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Fig1: The symptom severity and MMP-9 levels in boys with HKD/ADHD

Mentions: The mean (SD) of MMP-9 levels 49.13 (15.86) μg/l and median of MMP-9 levels 50.82 μg/l (25th percentile—43.14 μg/l; 75th percentile—56.34 μg/l) in study group amounted. The General Regression Models (GRM) were used to assess the effect of MMP-9 on HKD/ADHD symptoms (Table 2). The MMP-9 levels were significantly associated with symptoms severity of HKD and of ADHD (β = 0.34; p = 0.037 and β = 0.33; p = 0.043, respectively) (Fig. 1a, b). Furthermore, serum MMP-9 concentrations correlated with increase impulsiveness (β = 0.38; p = 0.019) (Fig. 2a, b).Table 2


Serum matrix metalloproteinase-9 levels and severity of symptoms in boys with attention deficit hyperactivity disorder ADHD/hyperkinetic disorder HKD.

Kadziela-Olech H, Cichocki P, Chwiesko J, Konstantynowicz J, Braszko JJ - Eur Child Adolesc Psychiatry (2014)

The symptom severity and MMP-9 levels in boys with HKD/ADHD
© Copyright Policy - OpenAccess
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC4291510&req=5

Fig1: The symptom severity and MMP-9 levels in boys with HKD/ADHD
Mentions: The mean (SD) of MMP-9 levels 49.13 (15.86) μg/l and median of MMP-9 levels 50.82 μg/l (25th percentile—43.14 μg/l; 75th percentile—56.34 μg/l) in study group amounted. The General Regression Models (GRM) were used to assess the effect of MMP-9 on HKD/ADHD symptoms (Table 2). The MMP-9 levels were significantly associated with symptoms severity of HKD and of ADHD (β = 0.34; p = 0.037 and β = 0.33; p = 0.043, respectively) (Fig. 1a, b). Furthermore, serum MMP-9 concentrations correlated with increase impulsiveness (β = 0.38; p = 0.019) (Fig. 2a, b).Table 2

Bottom Line: The serum levels of matrix metalloproteinase-9 (MMP-9) in neuropsychiatric disorders of adults have been widely investigated.Intellectual functions were measured using Wechsler Intelligence Scale for Children-Revised.According to the results, elevated levels of serum MMP-9 in boys with HKD may be associated with clinical impulsivity domain (β = 0.38; p = 0.019).

View Article: PubMed Central - PubMed

Affiliation: Medical University, Bialystok, Podlaskie, Poland, halina.kadziela-olech@umb.edu.pl.

ABSTRACT
The serum levels of matrix metalloproteinase-9 (MMP-9) in neuropsychiatric disorders of adults have been widely investigated. So far, no studies have been conducted on the relationship of MMP-9 and cognitive domains in children with two phenotype models, attention deficit/hyperactivity disorder and hyperkinetic disorder (ADHD/HKD). The aim of this research was to evaluate and test the hypothesis that serum MMP-9 levels are associated with the severity of symptoms in children with ADHD/HKD and to compare the results in two models of this disorder. The study group comprised 37 Caucasian boys aged 7-12 years with HKD, being a subset of the combined ADHD subtype. Intellectual functions were measured using Wechsler Intelligence Scale for Children-Revised. The analysis of serum concentrations of MMP-9 was based on a quantitative sandwich ELISA. The statistical regression analysis revealed a correlation between increased serum MMP-9 levels and severity of symptoms in the ADHD (β = 0.33; p = 0.043) and HKD (β = 0.34, p = 0.037) model. According to the results, elevated levels of serum MMP-9 in boys with HKD may be associated with clinical impulsivity domain (β = 0.38; p = 0.019).

Show MeSH
Related in: MedlinePlus