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Evaluation of neo-adjuvant, concurrent and adjuvant chemotherapy in the treatment of head and neck squamous cell carcinoma: a meta-analysis.

Akhlaghi F, Esmaeelinejad M, Shams A, Augend A - J Dent (Tehran) (2014)

Bottom Line: Squamous cell carcinoma (SCC) is the most common malignancy of the oral cavity.The authors searched all electronic databases (Medline, Embase and Cochrane) for all the articles published from 1970 to January 2011.Forty-six researches are included in this study.

View Article: PubMed Central - PubMed

Affiliation: Associate Professor,, Department of Oral and Maxillofacial Surgery, Faculty of Dentistry, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

ABSTRACT

Objective: Squamous cell carcinoma (SCC) is the most common malignancy of the oral cavity. This study aims to evaluate different treatment procedures including neo-adjuvant, concurrent and adjuvant therapy in treating squamous cell carcinoma of the head and neck by a meta-analysis.

Materials and methods: The authors searched all electronic databases (Medline, Embase and Cochrane) for all the articles published from 1970 to January 2011. Data of the evaluated treatment procedures (chemotherapy or radiotherapy), number of patients, publishing date and the authors' names have all been extracted from the articles and have been categorized in a table.

Results: Forty-six researches are included in this study. All three ways show that using chemotherapy after or with radiotherapy improves the vitality rate significantly (p-value< 0.01).

Conclusion: It is concluded that after deciding not to perform a surgery for treating SCC, the recommended treatment plan is chemotherapy and radiotherapy simultaneously.

No MeSH data available.


Related in: MedlinePlus

Evaluation of investigations about neo-adjuvant chemotherapy
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Related In: Results  -  Collection

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getmorefigures.php?uid=PMC4290757&req=5

f3-jod-11-290: Evaluation of investigations about neo-adjuvant chemotherapy

Mentions: Statistical analysis of the second group by fixed effect showed that chemotherapy before local surgical treatment improved the vitality rate significantly (p-value> 0.01), although statistical analysis by random effect and linear model was not significant (p-value> 0.05) (Fig 3). The heterogeneity test for these articles was significant (p-value< 0.05). Estimated Rosenthal’s number for evaluating publication bias was 2.646 articles.


Evaluation of neo-adjuvant, concurrent and adjuvant chemotherapy in the treatment of head and neck squamous cell carcinoma: a meta-analysis.

Akhlaghi F, Esmaeelinejad M, Shams A, Augend A - J Dent (Tehran) (2014)

Evaluation of investigations about neo-adjuvant chemotherapy
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4290757&req=5

f3-jod-11-290: Evaluation of investigations about neo-adjuvant chemotherapy
Mentions: Statistical analysis of the second group by fixed effect showed that chemotherapy before local surgical treatment improved the vitality rate significantly (p-value> 0.01), although statistical analysis by random effect and linear model was not significant (p-value> 0.05) (Fig 3). The heterogeneity test for these articles was significant (p-value< 0.05). Estimated Rosenthal’s number for evaluating publication bias was 2.646 articles.

Bottom Line: Squamous cell carcinoma (SCC) is the most common malignancy of the oral cavity.The authors searched all electronic databases (Medline, Embase and Cochrane) for all the articles published from 1970 to January 2011.Forty-six researches are included in this study.

View Article: PubMed Central - PubMed

Affiliation: Associate Professor,, Department of Oral and Maxillofacial Surgery, Faculty of Dentistry, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

ABSTRACT

Objective: Squamous cell carcinoma (SCC) is the most common malignancy of the oral cavity. This study aims to evaluate different treatment procedures including neo-adjuvant, concurrent and adjuvant therapy in treating squamous cell carcinoma of the head and neck by a meta-analysis.

Materials and methods: The authors searched all electronic databases (Medline, Embase and Cochrane) for all the articles published from 1970 to January 2011. Data of the evaluated treatment procedures (chemotherapy or radiotherapy), number of patients, publishing date and the authors' names have all been extracted from the articles and have been categorized in a table.

Results: Forty-six researches are included in this study. All three ways show that using chemotherapy after or with radiotherapy improves the vitality rate significantly (p-value< 0.01).

Conclusion: It is concluded that after deciding not to perform a surgery for treating SCC, the recommended treatment plan is chemotherapy and radiotherapy simultaneously.

No MeSH data available.


Related in: MedlinePlus