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Effect of intense physical exercise on hepcidin levels and selected parameters of iron metabolism in rowing athletes.

Skarpańska-Stejnborn A, Basta P, Trzeciak J, Szcześniak-Pilaczyńska Ł - Eur. J. Appl. Physiol. (2014)

Bottom Line: The high-intensity exercise test caused significant changes in hepcidin levels, IL-6, and iron metabolism parameters, with their subsequent return to baseline values during the recovery period.The serum iron levels decreased significantly during the recovery compared with pre- and post-exercise levels.These results suggest that the high-intensity ergometric test was reflected by a marked decrease in serum level of iron during the recovery period, but did not induce concomitant changes in the remaining erythrocyte parameters.

View Article: PubMed Central - PubMed

Affiliation: Department of Morphological and Health Sciences, Faculty of Physical Culture in Gorzów Wlkp., Gorzów Wielkopolski, Poland, ankass@poczta.onet.pl.

ABSTRACT

Purpose: Physical exercise, especially intense physical exercise, causes a number of unfavorable changes, including an increase in the level of pro-inflammatory cytokines with the resultant sequestration of iron in macrophages and decreased iron absorption. This can lead to a reduced supply of iron for erythroid progenitor cells and promote the development of anemia.

Method: This study included a group of 20 rowing athletes, members of the National Polish Rowing Team. The participants performed a 2,000-m maximum test on a rowing ergometer. Blood samples were taken from the antecubital vein prior to the exercise test, 1 min after completing the test, and after a 24-h recovery period. We determined the levels of hepcidin, interleukin 6 (IL-6), tumor necrosis factor α, soluble transferrin receptor, ferritin, total iron-binding capacity, unbound iron-binding capacity, iron, red blood cells, hemoglobin, hematocrit, mean corpuscular volume, creatine kinase, and myoglobin.

Result: The high-intensity exercise test caused significant changes in hepcidin levels, IL-6, and iron metabolism parameters, with their subsequent return to baseline values during the recovery period. The serum iron levels decreased significantly during the recovery compared with pre- and post-exercise levels.

Conclusion: These results suggest that the high-intensity ergometric test was reflected by a marked decrease in serum level of iron during the recovery period, but did not induce concomitant changes in the remaining erythrocyte parameters.

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Related in: MedlinePlus

Creatine kinase levels at baseline, immediately after exercise, and after a 1-day recovery period. Data are presented as mean ± SEM. *Statistically significant difference between trials (p < 0.05)
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Fig3: Creatine kinase levels at baseline, immediately after exercise, and after a 1-day recovery period. Data are presented as mean ± SEM. *Statistically significant difference between trials (p < 0.05)

Mentions: Finally, creatine kinase activity (Fig. 3) and serum myoglobin levels (Table 4) increased significantly in response to the exercise test and remained elevated after 1 day of recovery.Fig. 3


Effect of intense physical exercise on hepcidin levels and selected parameters of iron metabolism in rowing athletes.

Skarpańska-Stejnborn A, Basta P, Trzeciak J, Szcześniak-Pilaczyńska Ł - Eur. J. Appl. Physiol. (2014)

Creatine kinase levels at baseline, immediately after exercise, and after a 1-day recovery period. Data are presented as mean ± SEM. *Statistically significant difference between trials (p < 0.05)
© Copyright Policy - OpenAccess
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC4289533&req=5

Fig3: Creatine kinase levels at baseline, immediately after exercise, and after a 1-day recovery period. Data are presented as mean ± SEM. *Statistically significant difference between trials (p < 0.05)
Mentions: Finally, creatine kinase activity (Fig. 3) and serum myoglobin levels (Table 4) increased significantly in response to the exercise test and remained elevated after 1 day of recovery.Fig. 3

Bottom Line: The high-intensity exercise test caused significant changes in hepcidin levels, IL-6, and iron metabolism parameters, with their subsequent return to baseline values during the recovery period.The serum iron levels decreased significantly during the recovery compared with pre- and post-exercise levels.These results suggest that the high-intensity ergometric test was reflected by a marked decrease in serum level of iron during the recovery period, but did not induce concomitant changes in the remaining erythrocyte parameters.

View Article: PubMed Central - PubMed

Affiliation: Department of Morphological and Health Sciences, Faculty of Physical Culture in Gorzów Wlkp., Gorzów Wielkopolski, Poland, ankass@poczta.onet.pl.

ABSTRACT

Purpose: Physical exercise, especially intense physical exercise, causes a number of unfavorable changes, including an increase in the level of pro-inflammatory cytokines with the resultant sequestration of iron in macrophages and decreased iron absorption. This can lead to a reduced supply of iron for erythroid progenitor cells and promote the development of anemia.

Method: This study included a group of 20 rowing athletes, members of the National Polish Rowing Team. The participants performed a 2,000-m maximum test on a rowing ergometer. Blood samples were taken from the antecubital vein prior to the exercise test, 1 min after completing the test, and after a 24-h recovery period. We determined the levels of hepcidin, interleukin 6 (IL-6), tumor necrosis factor α, soluble transferrin receptor, ferritin, total iron-binding capacity, unbound iron-binding capacity, iron, red blood cells, hemoglobin, hematocrit, mean corpuscular volume, creatine kinase, and myoglobin.

Result: The high-intensity exercise test caused significant changes in hepcidin levels, IL-6, and iron metabolism parameters, with their subsequent return to baseline values during the recovery period. The serum iron levels decreased significantly during the recovery compared with pre- and post-exercise levels.

Conclusion: These results suggest that the high-intensity ergometric test was reflected by a marked decrease in serum level of iron during the recovery period, but did not induce concomitant changes in the remaining erythrocyte parameters.

Show MeSH
Related in: MedlinePlus