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The mechanisms of radiation-induced bystander effect.

Najafi M, Fardid R, Hadadi G, Fardid M - J Biomed Phys Eng (2014)

Bottom Line: The radiation-induced bystander effect is the phenomenon which non-irradiated cells exhibit effects along with their different levels as a result of signals received from nearby irradiated cells.These changes are confirmed by results of some In-Vivo studies.Most well-known important factors affecting radiation-induced bystander effect include free radicals, immune system factors, expression changes of some genes involved in inflammation pathway and epigenetic factors.

View Article: PubMed Central - PubMed

Affiliation: Department of Radiology, School of paramedical sciences, Shiraz University of Medical Sciences, Shiraz, Iran.

ABSTRACT
The radiation-induced bystander effect is the phenomenon which non-irradiated cells exhibit effects along with their different levels as a result of signals received from nearby irradiated cells. Responses of non-irradiated cells may include changes in process of translation, gene expression, cell proliferation, apoptosis and cells death. These changes are confirmed by results of some In-Vivo studies. Most well-known important factors affecting radiation-induced bystander effect include free radicals, immune system factors, expression changes of some genes involved in inflammation pathway and epigenetic factors.

No MeSH data available.


The mechanisms of radiation-induced bystander effect with alteration the expression of involved genes in the inflammation pathway
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Figure 1: The mechanisms of radiation-induced bystander effect with alteration the expression of involved genes in the inflammation pathway

Mentions: According to above mentioned, it is expected that acute doses of radiation through stimulating macrophages activities, causes the production of cytokines which leads to increase the expression of COX-2 and iNOS genes in non-irradiated cells. In-Vitro Studies have shown that the bystander effect can have a threefold increase of cyclooxygenase-2 in nearby non-irradiated cells [27]. In-vivo study also has shown multi fold increase in the expression of this gene during 72 hours after radiation of lung [29, 30]. (figure 1)


The mechanisms of radiation-induced bystander effect.

Najafi M, Fardid R, Hadadi G, Fardid M - J Biomed Phys Eng (2014)

The mechanisms of radiation-induced bystander effect with alteration the expression of involved genes in the inflammation pathway
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4289523&req=5

Figure 1: The mechanisms of radiation-induced bystander effect with alteration the expression of involved genes in the inflammation pathway
Mentions: According to above mentioned, it is expected that acute doses of radiation through stimulating macrophages activities, causes the production of cytokines which leads to increase the expression of COX-2 and iNOS genes in non-irradiated cells. In-Vitro Studies have shown that the bystander effect can have a threefold increase of cyclooxygenase-2 in nearby non-irradiated cells [27]. In-vivo study also has shown multi fold increase in the expression of this gene during 72 hours after radiation of lung [29, 30]. (figure 1)

Bottom Line: The radiation-induced bystander effect is the phenomenon which non-irradiated cells exhibit effects along with their different levels as a result of signals received from nearby irradiated cells.These changes are confirmed by results of some In-Vivo studies.Most well-known important factors affecting radiation-induced bystander effect include free radicals, immune system factors, expression changes of some genes involved in inflammation pathway and epigenetic factors.

View Article: PubMed Central - PubMed

Affiliation: Department of Radiology, School of paramedical sciences, Shiraz University of Medical Sciences, Shiraz, Iran.

ABSTRACT
The radiation-induced bystander effect is the phenomenon which non-irradiated cells exhibit effects along with their different levels as a result of signals received from nearby irradiated cells. Responses of non-irradiated cells may include changes in process of translation, gene expression, cell proliferation, apoptosis and cells death. These changes are confirmed by results of some In-Vivo studies. Most well-known important factors affecting radiation-induced bystander effect include free radicals, immune system factors, expression changes of some genes involved in inflammation pathway and epigenetic factors.

No MeSH data available.