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Evaluation of the effects of injection velocity and different gel concentrations on nanoparticles in hyperthermia therapy.

Javidi M, Heydari M, Karimi A, Haghpanahi M, Navidbakhsh M, Razmkon A - J Biomed Phys Eng (2014)

Bottom Line: The resultant heating configuration by magnetic fluid in the tumor is closely related to the dispersion of particles, frequency and intensity of magnetic field, and biological tissue properties.In the second part, by using experimental results of nanoparticles distribution inside Agarose gel according to various gel concentration, 0.5%, 1%, 2%, and 4%, as well as the injection velocity, 4 µL/min, 10 µL/min, 20 µL/min, and 40 µL/min, for 0.3 cc magnetite fluid, power dissipation inside gel has been calculated and used for temperature prediction inside of the gel.The results may have implications for treatment of the tumor and any kind of cancer diseases.

View Article: PubMed Central - PubMed

Affiliation: School of Mechanical Engineering, Iran University of Science and Technology, Tehran 16846, Iran ; Tissue Engineering and Biological Systems Research Laboratory, School of Mechanical Engineering, Iran University of Science and Technology, Tehran 16846, Iran.

ABSTRACT

Background and objective: In magnetic fluid hyperthermia therapy, controlling temperature elevation and optimizing heat generation is an immense challenge in practice. The resultant heating configuration by magnetic fluid in the tumor is closely related to the dispersion of particles, frequency and intensity of magnetic field, and biological tissue properties.

Methods: In this study, to solve heat transfer equation, we used COMSOL Multiphysics and to verify the model, an experimental setup has been used.  To show the accuracy of the model, simulations have been compared with experimental results. In the second part, by using experimental results of nanoparticles distribution inside Agarose gel according to various gel concentration, 0.5%, 1%, 2%, and 4%, as well as the injection velocity, 4 µL/min, 10 µL/min, 20 µL/min, and 40 µL/min, for 0.3 cc magnetite fluid, power dissipation inside gel has been calculated and used for temperature prediction inside of the gel.

Results: The Outcomes demonstrated that by increasing the flow rate injection at determined concentrations, mean temperature drops. In addition, 2% concentration has a higher mean temperature than semi spherical nanoparticles distribution.

Conclusion: The results may have implications for treatment of the tumor and any kind of cancer diseases.

No MeSH data available.


Related in: MedlinePlus

Temperature versus distance from centerline for different gel concentration at 3 µL / min infusion velocity.
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Figure 8: Temperature versus distance from centerline for different gel concentration at 3 µL / min infusion velocity.

Mentions: figures 8 and 9 indicate steady state temperature distribution inside gel at cylinder center line and at the maximum temperature position. As it can be seen from figure 7 with increasing concentration there is no regular pattern. From 0.5% to 2% concentration, mean temperature increases and from 2% to 4% concentration there is a decrement. In comparison to semi spherical distribution, 2% concentration curve has higher temperature in radial direction except region near center line.


Evaluation of the effects of injection velocity and different gel concentrations on nanoparticles in hyperthermia therapy.

Javidi M, Heydari M, Karimi A, Haghpanahi M, Navidbakhsh M, Razmkon A - J Biomed Phys Eng (2014)

Temperature versus distance from centerline for different gel concentration at 3 µL / min infusion velocity.
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4289522&req=5

Figure 8: Temperature versus distance from centerline for different gel concentration at 3 µL / min infusion velocity.
Mentions: figures 8 and 9 indicate steady state temperature distribution inside gel at cylinder center line and at the maximum temperature position. As it can be seen from figure 7 with increasing concentration there is no regular pattern. From 0.5% to 2% concentration, mean temperature increases and from 2% to 4% concentration there is a decrement. In comparison to semi spherical distribution, 2% concentration curve has higher temperature in radial direction except region near center line.

Bottom Line: The resultant heating configuration by magnetic fluid in the tumor is closely related to the dispersion of particles, frequency and intensity of magnetic field, and biological tissue properties.In the second part, by using experimental results of nanoparticles distribution inside Agarose gel according to various gel concentration, 0.5%, 1%, 2%, and 4%, as well as the injection velocity, 4 µL/min, 10 µL/min, 20 µL/min, and 40 µL/min, for 0.3 cc magnetite fluid, power dissipation inside gel has been calculated and used for temperature prediction inside of the gel.The results may have implications for treatment of the tumor and any kind of cancer diseases.

View Article: PubMed Central - PubMed

Affiliation: School of Mechanical Engineering, Iran University of Science and Technology, Tehran 16846, Iran ; Tissue Engineering and Biological Systems Research Laboratory, School of Mechanical Engineering, Iran University of Science and Technology, Tehran 16846, Iran.

ABSTRACT

Background and objective: In magnetic fluid hyperthermia therapy, controlling temperature elevation and optimizing heat generation is an immense challenge in practice. The resultant heating configuration by magnetic fluid in the tumor is closely related to the dispersion of particles, frequency and intensity of magnetic field, and biological tissue properties.

Methods: In this study, to solve heat transfer equation, we used COMSOL Multiphysics and to verify the model, an experimental setup has been used.  To show the accuracy of the model, simulations have been compared with experimental results. In the second part, by using experimental results of nanoparticles distribution inside Agarose gel according to various gel concentration, 0.5%, 1%, 2%, and 4%, as well as the injection velocity, 4 µL/min, 10 µL/min, 20 µL/min, and 40 µL/min, for 0.3 cc magnetite fluid, power dissipation inside gel has been calculated and used for temperature prediction inside of the gel.

Results: The Outcomes demonstrated that by increasing the flow rate injection at determined concentrations, mean temperature drops. In addition, 2% concentration has a higher mean temperature than semi spherical nanoparticles distribution.

Conclusion: The results may have implications for treatment of the tumor and any kind of cancer diseases.

No MeSH data available.


Related in: MedlinePlus