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Evaluation of the effects of injection velocity and different gel concentrations on nanoparticles in hyperthermia therapy.

Javidi M, Heydari M, Karimi A, Haghpanahi M, Navidbakhsh M, Razmkon A - J Biomed Phys Eng (2014)

Bottom Line: The resultant heating configuration by magnetic fluid in the tumor is closely related to the dispersion of particles, frequency and intensity of magnetic field, and biological tissue properties.In the second part, by using experimental results of nanoparticles distribution inside Agarose gel according to various gel concentration, 0.5%, 1%, 2%, and 4%, as well as the injection velocity, 4 µL/min, 10 µL/min, 20 µL/min, and 40 µL/min, for 0.3 cc magnetite fluid, power dissipation inside gel has been calculated and used for temperature prediction inside of the gel.The results may have implications for treatment of the tumor and any kind of cancer diseases.

View Article: PubMed Central - PubMed

Affiliation: School of Mechanical Engineering, Iran University of Science and Technology, Tehran 16846, Iran ; Tissue Engineering and Biological Systems Research Laboratory, School of Mechanical Engineering, Iran University of Science and Technology, Tehran 16846, Iran.

ABSTRACT

Background and objective: In magnetic fluid hyperthermia therapy, controlling temperature elevation and optimizing heat generation is an immense challenge in practice. The resultant heating configuration by magnetic fluid in the tumor is closely related to the dispersion of particles, frequency and intensity of magnetic field, and biological tissue properties.

Methods: In this study, to solve heat transfer equation, we used COMSOL Multiphysics and to verify the model, an experimental setup has been used.  To show the accuracy of the model, simulations have been compared with experimental results. In the second part, by using experimental results of nanoparticles distribution inside Agarose gel according to various gel concentration, 0.5%, 1%, 2%, and 4%, as well as the injection velocity, 4 µL/min, 10 µL/min, 20 µL/min, and 40 µL/min, for 0.3 cc magnetite fluid, power dissipation inside gel has been calculated and used for temperature prediction inside of the gel.

Results: The Outcomes demonstrated that by increasing the flow rate injection at determined concentrations, mean temperature drops. In addition, 2% concentration has a higher mean temperature than semi spherical nanoparticles distribution.

Conclusion: The results may have implications for treatment of the tumor and any kind of cancer diseases.

No MeSH data available.


Related in: MedlinePlus

Schematic of coil and sample.
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Figure 1: Schematic of coil and sample.

Mentions: In anatomical studies, the vascular structure of a tumor has been found to be different from that of normal tissue [34]; the geometry of the vasculature in tumors is very complicated and quantitative data on this irregular structure is sparse. Therefore, the vascular structures of tumor and normal tissue have been assumed to be the same in order to simplify the physical model. Based on this assumption, the entire domain, including tissue and tumor, is taken to be a cylinder. See figure 1.


Evaluation of the effects of injection velocity and different gel concentrations on nanoparticles in hyperthermia therapy.

Javidi M, Heydari M, Karimi A, Haghpanahi M, Navidbakhsh M, Razmkon A - J Biomed Phys Eng (2014)

Schematic of coil and sample.
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4289522&req=5

Figure 1: Schematic of coil and sample.
Mentions: In anatomical studies, the vascular structure of a tumor has been found to be different from that of normal tissue [34]; the geometry of the vasculature in tumors is very complicated and quantitative data on this irregular structure is sparse. Therefore, the vascular structures of tumor and normal tissue have been assumed to be the same in order to simplify the physical model. Based on this assumption, the entire domain, including tissue and tumor, is taken to be a cylinder. See figure 1.

Bottom Line: The resultant heating configuration by magnetic fluid in the tumor is closely related to the dispersion of particles, frequency and intensity of magnetic field, and biological tissue properties.In the second part, by using experimental results of nanoparticles distribution inside Agarose gel according to various gel concentration, 0.5%, 1%, 2%, and 4%, as well as the injection velocity, 4 µL/min, 10 µL/min, 20 µL/min, and 40 µL/min, for 0.3 cc magnetite fluid, power dissipation inside gel has been calculated and used for temperature prediction inside of the gel.The results may have implications for treatment of the tumor and any kind of cancer diseases.

View Article: PubMed Central - PubMed

Affiliation: School of Mechanical Engineering, Iran University of Science and Technology, Tehran 16846, Iran ; Tissue Engineering and Biological Systems Research Laboratory, School of Mechanical Engineering, Iran University of Science and Technology, Tehran 16846, Iran.

ABSTRACT

Background and objective: In magnetic fluid hyperthermia therapy, controlling temperature elevation and optimizing heat generation is an immense challenge in practice. The resultant heating configuration by magnetic fluid in the tumor is closely related to the dispersion of particles, frequency and intensity of magnetic field, and biological tissue properties.

Methods: In this study, to solve heat transfer equation, we used COMSOL Multiphysics and to verify the model, an experimental setup has been used.  To show the accuracy of the model, simulations have been compared with experimental results. In the second part, by using experimental results of nanoparticles distribution inside Agarose gel according to various gel concentration, 0.5%, 1%, 2%, and 4%, as well as the injection velocity, 4 µL/min, 10 µL/min, 20 µL/min, and 40 µL/min, for 0.3 cc magnetite fluid, power dissipation inside gel has been calculated and used for temperature prediction inside of the gel.

Results: The Outcomes demonstrated that by increasing the flow rate injection at determined concentrations, mean temperature drops. In addition, 2% concentration has a higher mean temperature than semi spherical nanoparticles distribution.

Conclusion: The results may have implications for treatment of the tumor and any kind of cancer diseases.

No MeSH data available.


Related in: MedlinePlus