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The effects of Wubeizi ointment on the proliferation of keloid-derived fibroblasts.

Ding JC, Tang ZM, Zhai XX, Chen XH, Li JG, Zhang CX - Cell Biochem. Biophys. (2015)

Bottom Line: The primary cells of the keloid-derived fibroblasts were cultured and the effectiveness of the WBZ ointment at different concentrations was examined by MTT colorimetric methods on keloid-derived fibroblasts.The WBZ ointment showed inhibitory effects on proliferating the keloid-derived fibroblasts (P < 0.01)in a time- and dose-dependent manner.The proportion of cells in S stage was significantly higher in each of the WBZ ointment group than in the control group (P<0.01), and the proportion of G2 + M stage cells was significantly lower than that of control group, which was statistically significant (P < 0.01).The inhibitory effects of the S and G2 + M stage increased with higher drug concentrations (P < 0.05).

View Article: PubMed Central - PubMed

Affiliation: Department of Plastic Surgery, Xuzhou Central Hospital, 199# South Jiefang Road, Xuzhou, 221009, Jiangsu, China, djicun@126.com.

ABSTRACT

Unlabelled: To evaluate the effectiveness of the Wubeizi (WBZ) ointment on keloid-derived fibroblasts. The primary cells of the keloid-derived fibroblasts were cultured and the effectiveness of the WBZ ointment at different concentrations was examined by MTT colorimetric methods on keloid-derived fibroblasts. The WBZ ointment showed inhibitory effects on proliferating the keloid-derived fibroblasts (P < 0.01)in a time- and dose-dependent manner. The proportion of cells in S stage was significantly higher in each of the WBZ ointment group than in the control group (P<0.01), and the proportion of G2 + M stage cells was significantly lower than that of control group, which was statistically significant (P < 0.01).The inhibitory effects of the S and G2 + M stage increased with higher drug concentrations (P < 0.05).

Conclusion: The WBZ ointment can inhibit the proliferation of the keloid-derived fibroblasts in a time- and dose- dependent manner.

No MeSH data available.


Inhibitory effects of different concentrations of WBZ ointment on the proliferation of keloid-derived fibroblasts
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Related In: Results  -  Collection


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Fig1: Inhibitory effects of different concentrations of WBZ ointment on the proliferation of keloid-derived fibroblasts

Mentions: The proliferation rates at the three time points, suggested that at different doses, the ointment manifested inhibitory effects against the fibroblast, independent of time and dose, as shown in Fig. 1.Fig. 1


The effects of Wubeizi ointment on the proliferation of keloid-derived fibroblasts.

Ding JC, Tang ZM, Zhai XX, Chen XH, Li JG, Zhang CX - Cell Biochem. Biophys. (2015)

Inhibitory effects of different concentrations of WBZ ointment on the proliferation of keloid-derived fibroblasts
© Copyright Policy - OpenAccess
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC4289516&req=5

Fig1: Inhibitory effects of different concentrations of WBZ ointment on the proliferation of keloid-derived fibroblasts
Mentions: The proliferation rates at the three time points, suggested that at different doses, the ointment manifested inhibitory effects against the fibroblast, independent of time and dose, as shown in Fig. 1.Fig. 1

Bottom Line: The primary cells of the keloid-derived fibroblasts were cultured and the effectiveness of the WBZ ointment at different concentrations was examined by MTT colorimetric methods on keloid-derived fibroblasts.The WBZ ointment showed inhibitory effects on proliferating the keloid-derived fibroblasts (P < 0.01)in a time- and dose-dependent manner.The proportion of cells in S stage was significantly higher in each of the WBZ ointment group than in the control group (P<0.01), and the proportion of G2 + M stage cells was significantly lower than that of control group, which was statistically significant (P < 0.01).The inhibitory effects of the S and G2 + M stage increased with higher drug concentrations (P < 0.05).

View Article: PubMed Central - PubMed

Affiliation: Department of Plastic Surgery, Xuzhou Central Hospital, 199# South Jiefang Road, Xuzhou, 221009, Jiangsu, China, djicun@126.com.

ABSTRACT

Unlabelled: To evaluate the effectiveness of the Wubeizi (WBZ) ointment on keloid-derived fibroblasts. The primary cells of the keloid-derived fibroblasts were cultured and the effectiveness of the WBZ ointment at different concentrations was examined by MTT colorimetric methods on keloid-derived fibroblasts. The WBZ ointment showed inhibitory effects on proliferating the keloid-derived fibroblasts (P < 0.01)in a time- and dose-dependent manner. The proportion of cells in S stage was significantly higher in each of the WBZ ointment group than in the control group (P<0.01), and the proportion of G2 + M stage cells was significantly lower than that of control group, which was statistically significant (P < 0.01).The inhibitory effects of the S and G2 + M stage increased with higher drug concentrations (P < 0.05).

Conclusion: The WBZ ointment can inhibit the proliferation of the keloid-derived fibroblasts in a time- and dose- dependent manner.

No MeSH data available.