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Association of serum hepcidin levels with the presence and severity of obstructive sleep apnea syndrome.

Liu Y, Yu Z, Hua D, Chen Y, Zheng S, Wang L - Med. Sci. Monit. (2015)

Bottom Line: Hepcidin, a 25-kD peptide hormone produced by the liver, modulates acute inflammatory responses.OSAS patients had significantly higher serum hepcidin levels compared with healthy controls.Elevated serum hepcidin levels are associated with the presence and severity of OSAS.

View Article: PubMed Central - PubMed

Affiliation: Department of Emergency, Affiliated Hospital, Weifang Medical College, Weifang, Shandong, China (mainland).

ABSTRACT

Background: Inflammation is thought to be involved in the pathogenesis of obstructive sleep apnea syndrome (OSAS). Hepcidin, a 25-kD peptide hormone produced by the liver, modulates acute inflammatory responses. This study aimed to determine the association of serum levels of hepcidin with the presence and severity of OSAS.

Material/methods: We enrolled 184 patients with OSAS and 110 healthy subjects. Serum levels of hepcidin were evaluated using enzyme-linked immunosorbent assay (ELISA) method.

Results: OSAS patients had significantly higher serum hepcidin levels compared with healthy controls. Multivariable logistic regression analysis indicated that serum hepcidin levels were an independent determinant of the presence of OSAS (OR 1.224, 95% CI 1.159-1.292; P<0.001). Serum hepcidin levels were significantly elevated in severe OSAS patients compared with mild and moderate OSAS patients. Spearman correlation analysis revealed that serum hepcidin levels were correlated with the severity of OSAS. In addition, serum levels of hepcidin were correlated with apnea-hypopnea index (AHI) in patients with OSAS.

Conclusions: Elevated serum hepcidin levels are associated with the presence and severity of OSAS.

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Related in: MedlinePlus

Correlation of serum hepcidin levels with AHI.
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f2-medscimonit-21-27: Correlation of serum hepcidin levels with AHI.

Mentions: Spearman correlation analysis showed that serum hepcidin levels in OSAS patients were correlated with AHI (r=0.239, P<0.001). Figure 2 shows the correlation between serum hepcidin levels and AHI.


Association of serum hepcidin levels with the presence and severity of obstructive sleep apnea syndrome.

Liu Y, Yu Z, Hua D, Chen Y, Zheng S, Wang L - Med. Sci. Monit. (2015)

Correlation of serum hepcidin levels with AHI.
© Copyright Policy
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC4289483&req=5

f2-medscimonit-21-27: Correlation of serum hepcidin levels with AHI.
Mentions: Spearman correlation analysis showed that serum hepcidin levels in OSAS patients were correlated with AHI (r=0.239, P<0.001). Figure 2 shows the correlation between serum hepcidin levels and AHI.

Bottom Line: Hepcidin, a 25-kD peptide hormone produced by the liver, modulates acute inflammatory responses.OSAS patients had significantly higher serum hepcidin levels compared with healthy controls.Elevated serum hepcidin levels are associated with the presence and severity of OSAS.

View Article: PubMed Central - PubMed

Affiliation: Department of Emergency, Affiliated Hospital, Weifang Medical College, Weifang, Shandong, China (mainland).

ABSTRACT

Background: Inflammation is thought to be involved in the pathogenesis of obstructive sleep apnea syndrome (OSAS). Hepcidin, a 25-kD peptide hormone produced by the liver, modulates acute inflammatory responses. This study aimed to determine the association of serum levels of hepcidin with the presence and severity of OSAS.

Material/methods: We enrolled 184 patients with OSAS and 110 healthy subjects. Serum levels of hepcidin were evaluated using enzyme-linked immunosorbent assay (ELISA) method.

Results: OSAS patients had significantly higher serum hepcidin levels compared with healthy controls. Multivariable logistic regression analysis indicated that serum hepcidin levels were an independent determinant of the presence of OSAS (OR 1.224, 95% CI 1.159-1.292; P<0.001). Serum hepcidin levels were significantly elevated in severe OSAS patients compared with mild and moderate OSAS patients. Spearman correlation analysis revealed that serum hepcidin levels were correlated with the severity of OSAS. In addition, serum levels of hepcidin were correlated with apnea-hypopnea index (AHI) in patients with OSAS.

Conclusions: Elevated serum hepcidin levels are associated with the presence and severity of OSAS.

Show MeSH
Related in: MedlinePlus