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Association of serum hepcidin levels with the presence and severity of obstructive sleep apnea syndrome.

Liu Y, Yu Z, Hua D, Chen Y, Zheng S, Wang L - Med. Sci. Monit. (2015)

Bottom Line: Hepcidin, a 25-kD peptide hormone produced by the liver, modulates acute inflammatory responses.OSAS patients had significantly higher serum hepcidin levels compared with healthy controls.Elevated serum hepcidin levels are associated with the presence and severity of OSAS.

View Article: PubMed Central - PubMed

Affiliation: Department of Emergency, Affiliated Hospital, Weifang Medical College, Weifang, Shandong, China (mainland).

ABSTRACT

Background: Inflammation is thought to be involved in the pathogenesis of obstructive sleep apnea syndrome (OSAS). Hepcidin, a 25-kD peptide hormone produced by the liver, modulates acute inflammatory responses. This study aimed to determine the association of serum levels of hepcidin with the presence and severity of OSAS.

Material/methods: We enrolled 184 patients with OSAS and 110 healthy subjects. Serum levels of hepcidin were evaluated using enzyme-linked immunosorbent assay (ELISA) method.

Results: OSAS patients had significantly higher serum hepcidin levels compared with healthy controls. Multivariable logistic regression analysis indicated that serum hepcidin levels were an independent determinant of the presence of OSAS (OR 1.224, 95% CI 1.159-1.292; P<0.001). Serum hepcidin levels were significantly elevated in severe OSAS patients compared with mild and moderate OSAS patients. Spearman correlation analysis revealed that serum hepcidin levels were correlated with the severity of OSAS. In addition, serum levels of hepcidin were correlated with apnea-hypopnea index (AHI) in patients with OSAS.

Conclusions: Elevated serum hepcidin levels are associated with the presence and severity of OSAS.

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Related in: MedlinePlus

Serum hepcidin levels in mild, moderate, and severe OSAS patients. Severe OSAS patients showed significantly higher levels of serum hepcidin compared with mild and moderate OSAS patients. In addition, Moderate OSAS patients had significantly higher serum hepcidin levels compared with mild OSAS patients.
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f1-medscimonit-21-27: Serum hepcidin levels in mild, moderate, and severe OSAS patients. Severe OSAS patients showed significantly higher levels of serum hepcidin compared with mild and moderate OSAS patients. In addition, Moderate OSAS patients had significantly higher serum hepcidin levels compared with mild OSAS patients.

Mentions: Serum hepcidin levels in mild, moderate, and severe OSAS patients are shown in Figure 1. Severe OSAS patients had significantly higher serum hepcidin levels compared with those in mild and moderate OSAS patients (P<0.001 and P=0.014, respectively). Furthermore, serum hepcidin levels were significantly elevated in moderate OSAS patients compared with mild OSAS patients (P=0.018). Spearman correlation analysis suggested that serum hepcidin levels were correlated with the severity of OSAS (r=0.293, P<0.001).


Association of serum hepcidin levels with the presence and severity of obstructive sleep apnea syndrome.

Liu Y, Yu Z, Hua D, Chen Y, Zheng S, Wang L - Med. Sci. Monit. (2015)

Serum hepcidin levels in mild, moderate, and severe OSAS patients. Severe OSAS patients showed significantly higher levels of serum hepcidin compared with mild and moderate OSAS patients. In addition, Moderate OSAS patients had significantly higher serum hepcidin levels compared with mild OSAS patients.
© Copyright Policy
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC4289483&req=5

f1-medscimonit-21-27: Serum hepcidin levels in mild, moderate, and severe OSAS patients. Severe OSAS patients showed significantly higher levels of serum hepcidin compared with mild and moderate OSAS patients. In addition, Moderate OSAS patients had significantly higher serum hepcidin levels compared with mild OSAS patients.
Mentions: Serum hepcidin levels in mild, moderate, and severe OSAS patients are shown in Figure 1. Severe OSAS patients had significantly higher serum hepcidin levels compared with those in mild and moderate OSAS patients (P<0.001 and P=0.014, respectively). Furthermore, serum hepcidin levels were significantly elevated in moderate OSAS patients compared with mild OSAS patients (P=0.018). Spearman correlation analysis suggested that serum hepcidin levels were correlated with the severity of OSAS (r=0.293, P<0.001).

Bottom Line: Hepcidin, a 25-kD peptide hormone produced by the liver, modulates acute inflammatory responses.OSAS patients had significantly higher serum hepcidin levels compared with healthy controls.Elevated serum hepcidin levels are associated with the presence and severity of OSAS.

View Article: PubMed Central - PubMed

Affiliation: Department of Emergency, Affiliated Hospital, Weifang Medical College, Weifang, Shandong, China (mainland).

ABSTRACT

Background: Inflammation is thought to be involved in the pathogenesis of obstructive sleep apnea syndrome (OSAS). Hepcidin, a 25-kD peptide hormone produced by the liver, modulates acute inflammatory responses. This study aimed to determine the association of serum levels of hepcidin with the presence and severity of OSAS.

Material/methods: We enrolled 184 patients with OSAS and 110 healthy subjects. Serum levels of hepcidin were evaluated using enzyme-linked immunosorbent assay (ELISA) method.

Results: OSAS patients had significantly higher serum hepcidin levels compared with healthy controls. Multivariable logistic regression analysis indicated that serum hepcidin levels were an independent determinant of the presence of OSAS (OR 1.224, 95% CI 1.159-1.292; P<0.001). Serum hepcidin levels were significantly elevated in severe OSAS patients compared with mild and moderate OSAS patients. Spearman correlation analysis revealed that serum hepcidin levels were correlated with the severity of OSAS. In addition, serum levels of hepcidin were correlated with apnea-hypopnea index (AHI) in patients with OSAS.

Conclusions: Elevated serum hepcidin levels are associated with the presence and severity of OSAS.

Show MeSH
Related in: MedlinePlus