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Clinical value of whole-body PET/CT in patients with active rheumatic diseases.

Yamashita H, Kubota K, Mimori A - Arthritis Res. Ther. (2014)

Bottom Line: Positron emission tomography (PET) provides highly sensitive, quantitative imaging at a molecular level, revealing the important pathophysiological processes underlying inflammation.This review provides an overview of the current utility of 18 F-fluorodeoxyglucose (FDG)-PET/computed tomography (CT) in patients with active rheumatic diseases such as rheumatoid arthritis, spondyloarthritis, polymyalgia rheumatica, adult-onset Still's disease, relapsing polychondritis, immunoglobulin G4-related disease, large-vessel vasculitis, Wegener's granulomatosis, polymyositis, and dermatomyositis.We also discuss the role of FDG-PET/CT in the diagnosis and monitoring of these diseases.

View Article: PubMed Central - PubMed

Affiliation: Division of Rheumatic Diseases, National Center for Global Health and Medicine, 1-21-1, Toyama Shinjuku-ku, Tokyo 162-8655, Japan. hiroyuki_yjp2005@yahoo.co.jp

ABSTRACT
Advanced imaging techniques may enable early diagnosis and monitoring of therapy in various rheumatic diseases. To prevent irreversible tissue damage, inflammatory rheumatic disease must be diagnosed and treated in pre-clinical stages, requiring highly sensitive detection techniques. Positron emission tomography (PET) provides highly sensitive, quantitative imaging at a molecular level, revealing the important pathophysiological processes underlying inflammation. This review provides an overview of the current utility of 18 F-fluorodeoxyglucose (FDG)-PET/computed tomography (CT) in patients with active rheumatic diseases such as rheumatoid arthritis, spondyloarthritis, polymyalgia rheumatica, adult-onset Still's disease, relapsing polychondritis, immunoglobulin G4-related disease, large-vessel vasculitis, Wegener's granulomatosis, polymyositis, and dermatomyositis. We also discuss the role of FDG-PET/CT in the diagnosis and monitoring of these diseases.

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18 F-fluorodeoxyglucose-positron emission tomography/computed tomography (FDG-PET/CT) images at diagnosis and after steroid treatment in a patient with isolated polymyalgia rheumatica (PMR). FDG uptake in the (A) shoulders, (B) spinous processes of the lower lumbar vertebrae, (C) iliopectineal bursitis, and (D) ischial tuberosity is normalized after therapy (A-D, right panels).
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Fig3: 18 F-fluorodeoxyglucose-positron emission tomography/computed tomography (FDG-PET/CT) images at diagnosis and after steroid treatment in a patient with isolated polymyalgia rheumatica (PMR). FDG uptake in the (A) shoulders, (B) spinous processes of the lower lumbar vertebrae, (C) iliopectineal bursitis, and (D) ischial tuberosity is normalized after therapy (A-D, right panels).

Mentions: Typical FDG-PET/CT images of PMR are shown in Figure 3 [30]. PMR is an inflammatory rheumatic disease characterized by aches and morning stiffness in the shoulders, hip girdle, and neck in patients over 50 years of age. PMR is diagnosed by the exclusion of other disorders causing similar complaints and by its rapid response to low-dose corticosteroid therapy [31,32]. Although its pathology is unknown, synovitis and bursitis are common features of this disease. MRI and US frequently reveal inflammation of the tenosynovial sheaths of the hands or feet [33-35].Figure 3


Clinical value of whole-body PET/CT in patients with active rheumatic diseases.

Yamashita H, Kubota K, Mimori A - Arthritis Res. Ther. (2014)

18 F-fluorodeoxyglucose-positron emission tomography/computed tomography (FDG-PET/CT) images at diagnosis and after steroid treatment in a patient with isolated polymyalgia rheumatica (PMR). FDG uptake in the (A) shoulders, (B) spinous processes of the lower lumbar vertebrae, (C) iliopectineal bursitis, and (D) ischial tuberosity is normalized after therapy (A-D, right panels).
© Copyright Policy - open-access
Related In: Results  -  Collection

License 1 - License 2
Show All Figures
getmorefigures.php?uid=PMC4289312&req=5

Fig3: 18 F-fluorodeoxyglucose-positron emission tomography/computed tomography (FDG-PET/CT) images at diagnosis and after steroid treatment in a patient with isolated polymyalgia rheumatica (PMR). FDG uptake in the (A) shoulders, (B) spinous processes of the lower lumbar vertebrae, (C) iliopectineal bursitis, and (D) ischial tuberosity is normalized after therapy (A-D, right panels).
Mentions: Typical FDG-PET/CT images of PMR are shown in Figure 3 [30]. PMR is an inflammatory rheumatic disease characterized by aches and morning stiffness in the shoulders, hip girdle, and neck in patients over 50 years of age. PMR is diagnosed by the exclusion of other disorders causing similar complaints and by its rapid response to low-dose corticosteroid therapy [31,32]. Although its pathology is unknown, synovitis and bursitis are common features of this disease. MRI and US frequently reveal inflammation of the tenosynovial sheaths of the hands or feet [33-35].Figure 3

Bottom Line: Positron emission tomography (PET) provides highly sensitive, quantitative imaging at a molecular level, revealing the important pathophysiological processes underlying inflammation.This review provides an overview of the current utility of 18 F-fluorodeoxyglucose (FDG)-PET/computed tomography (CT) in patients with active rheumatic diseases such as rheumatoid arthritis, spondyloarthritis, polymyalgia rheumatica, adult-onset Still's disease, relapsing polychondritis, immunoglobulin G4-related disease, large-vessel vasculitis, Wegener's granulomatosis, polymyositis, and dermatomyositis.We also discuss the role of FDG-PET/CT in the diagnosis and monitoring of these diseases.

View Article: PubMed Central - PubMed

Affiliation: Division of Rheumatic Diseases, National Center for Global Health and Medicine, 1-21-1, Toyama Shinjuku-ku, Tokyo 162-8655, Japan. hiroyuki_yjp2005@yahoo.co.jp

ABSTRACT
Advanced imaging techniques may enable early diagnosis and monitoring of therapy in various rheumatic diseases. To prevent irreversible tissue damage, inflammatory rheumatic disease must be diagnosed and treated in pre-clinical stages, requiring highly sensitive detection techniques. Positron emission tomography (PET) provides highly sensitive, quantitative imaging at a molecular level, revealing the important pathophysiological processes underlying inflammation. This review provides an overview of the current utility of 18 F-fluorodeoxyglucose (FDG)-PET/computed tomography (CT) in patients with active rheumatic diseases such as rheumatoid arthritis, spondyloarthritis, polymyalgia rheumatica, adult-onset Still's disease, relapsing polychondritis, immunoglobulin G4-related disease, large-vessel vasculitis, Wegener's granulomatosis, polymyositis, and dermatomyositis. We also discuss the role of FDG-PET/CT in the diagnosis and monitoring of these diseases.

Show MeSH
Related in: MedlinePlus