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Clinical value of whole-body PET/CT in patients with active rheumatic diseases.

Yamashita H, Kubota K, Mimori A - Arthritis Res. Ther. (2014)

Bottom Line: Positron emission tomography (PET) provides highly sensitive, quantitative imaging at a molecular level, revealing the important pathophysiological processes underlying inflammation.This review provides an overview of the current utility of 18 F-fluorodeoxyglucose (FDG)-PET/computed tomography (CT) in patients with active rheumatic diseases such as rheumatoid arthritis, spondyloarthritis, polymyalgia rheumatica, adult-onset Still's disease, relapsing polychondritis, immunoglobulin G4-related disease, large-vessel vasculitis, Wegener's granulomatosis, polymyositis, and dermatomyositis.We also discuss the role of FDG-PET/CT in the diagnosis and monitoring of these diseases.

View Article: PubMed Central - PubMed

Affiliation: Division of Rheumatic Diseases, National Center for Global Health and Medicine, 1-21-1, Toyama Shinjuku-ku, Tokyo 162-8655, Japan. hiroyuki_yjp2005@yahoo.co.jp

ABSTRACT
Advanced imaging techniques may enable early diagnosis and monitoring of therapy in various rheumatic diseases. To prevent irreversible tissue damage, inflammatory rheumatic disease must be diagnosed and treated in pre-clinical stages, requiring highly sensitive detection techniques. Positron emission tomography (PET) provides highly sensitive, quantitative imaging at a molecular level, revealing the important pathophysiological processes underlying inflammation. This review provides an overview of the current utility of 18 F-fluorodeoxyglucose (FDG)-PET/computed tomography (CT) in patients with active rheumatic diseases such as rheumatoid arthritis, spondyloarthritis, polymyalgia rheumatica, adult-onset Still's disease, relapsing polychondritis, immunoglobulin G4-related disease, large-vessel vasculitis, Wegener's granulomatosis, polymyositis, and dermatomyositis. We also discuss the role of FDG-PET/CT in the diagnosis and monitoring of these diseases.

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Related in: MedlinePlus

Typical18 F-fluorodeoxyglucose-positron emission tomography/computed tomography (FDG-PET/CT) and magnetic resonance imaging (MRI) findings in patients with spondyloarthritis (SpA), enthesitis of the ischial tuberosity, and sacroiliitis. (A) Whole-body FDG-PET/CT in a patient with SpA reveals FDG accumulation in the ischial tuberosity (A1). MRI (fat-suppressed, T1-weighted imaging) reveals enhancement in the areas surrounding the ischial tuberosity, consistent with enthesitis (A2-3). (B) FDG accumulation suggestive of sacroiliitis in the sacroiliac joint in patients 1 and 2 on FDG-PET/CT (B1). MRI (fat-suppressed, T1-weighted imaging) identifies contrast enhancement in patient 2 (B2).
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Fig2: Typical18 F-fluorodeoxyglucose-positron emission tomography/computed tomography (FDG-PET/CT) and magnetic resonance imaging (MRI) findings in patients with spondyloarthritis (SpA), enthesitis of the ischial tuberosity, and sacroiliitis. (A) Whole-body FDG-PET/CT in a patient with SpA reveals FDG accumulation in the ischial tuberosity (A1). MRI (fat-suppressed, T1-weighted imaging) reveals enhancement in the areas surrounding the ischial tuberosity, consistent with enthesitis (A2-3). (B) FDG accumulation suggestive of sacroiliitis in the sacroiliac joint in patients 1 and 2 on FDG-PET/CT (B1). MRI (fat-suppressed, T1-weighted imaging) identifies contrast enhancement in patient 2 (B2).

Mentions: Typical FDG-PET/CT images of spondyloarthritis (SpA) are shown in Figure 2 [24]. SpA includes ankylosing spondylitis (AS), psoriatic arthritis (PsA), reactive arthritis, enteropathic arthritis, and undifferentiated SpA [25]. SpA often involves enthesitis, sacroiliitis, and inflammatory spondylitis [26].Figure 2


Clinical value of whole-body PET/CT in patients with active rheumatic diseases.

Yamashita H, Kubota K, Mimori A - Arthritis Res. Ther. (2014)

Typical18 F-fluorodeoxyglucose-positron emission tomography/computed tomography (FDG-PET/CT) and magnetic resonance imaging (MRI) findings in patients with spondyloarthritis (SpA), enthesitis of the ischial tuberosity, and sacroiliitis. (A) Whole-body FDG-PET/CT in a patient with SpA reveals FDG accumulation in the ischial tuberosity (A1). MRI (fat-suppressed, T1-weighted imaging) reveals enhancement in the areas surrounding the ischial tuberosity, consistent with enthesitis (A2-3). (B) FDG accumulation suggestive of sacroiliitis in the sacroiliac joint in patients 1 and 2 on FDG-PET/CT (B1). MRI (fat-suppressed, T1-weighted imaging) identifies contrast enhancement in patient 2 (B2).
© Copyright Policy - open-access
Related In: Results  -  Collection

License 1 - License 2
Show All Figures
getmorefigures.php?uid=PMC4289312&req=5

Fig2: Typical18 F-fluorodeoxyglucose-positron emission tomography/computed tomography (FDG-PET/CT) and magnetic resonance imaging (MRI) findings in patients with spondyloarthritis (SpA), enthesitis of the ischial tuberosity, and sacroiliitis. (A) Whole-body FDG-PET/CT in a patient with SpA reveals FDG accumulation in the ischial tuberosity (A1). MRI (fat-suppressed, T1-weighted imaging) reveals enhancement in the areas surrounding the ischial tuberosity, consistent with enthesitis (A2-3). (B) FDG accumulation suggestive of sacroiliitis in the sacroiliac joint in patients 1 and 2 on FDG-PET/CT (B1). MRI (fat-suppressed, T1-weighted imaging) identifies contrast enhancement in patient 2 (B2).
Mentions: Typical FDG-PET/CT images of spondyloarthritis (SpA) are shown in Figure 2 [24]. SpA includes ankylosing spondylitis (AS), psoriatic arthritis (PsA), reactive arthritis, enteropathic arthritis, and undifferentiated SpA [25]. SpA often involves enthesitis, sacroiliitis, and inflammatory spondylitis [26].Figure 2

Bottom Line: Positron emission tomography (PET) provides highly sensitive, quantitative imaging at a molecular level, revealing the important pathophysiological processes underlying inflammation.This review provides an overview of the current utility of 18 F-fluorodeoxyglucose (FDG)-PET/computed tomography (CT) in patients with active rheumatic diseases such as rheumatoid arthritis, spondyloarthritis, polymyalgia rheumatica, adult-onset Still's disease, relapsing polychondritis, immunoglobulin G4-related disease, large-vessel vasculitis, Wegener's granulomatosis, polymyositis, and dermatomyositis.We also discuss the role of FDG-PET/CT in the diagnosis and monitoring of these diseases.

View Article: PubMed Central - PubMed

Affiliation: Division of Rheumatic Diseases, National Center for Global Health and Medicine, 1-21-1, Toyama Shinjuku-ku, Tokyo 162-8655, Japan. hiroyuki_yjp2005@yahoo.co.jp

ABSTRACT
Advanced imaging techniques may enable early diagnosis and monitoring of therapy in various rheumatic diseases. To prevent irreversible tissue damage, inflammatory rheumatic disease must be diagnosed and treated in pre-clinical stages, requiring highly sensitive detection techniques. Positron emission tomography (PET) provides highly sensitive, quantitative imaging at a molecular level, revealing the important pathophysiological processes underlying inflammation. This review provides an overview of the current utility of 18 F-fluorodeoxyglucose (FDG)-PET/computed tomography (CT) in patients with active rheumatic diseases such as rheumatoid arthritis, spondyloarthritis, polymyalgia rheumatica, adult-onset Still's disease, relapsing polychondritis, immunoglobulin G4-related disease, large-vessel vasculitis, Wegener's granulomatosis, polymyositis, and dermatomyositis. We also discuss the role of FDG-PET/CT in the diagnosis and monitoring of these diseases.

Show MeSH
Related in: MedlinePlus