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Rationale and study design of the NEuroCardiac TherApy foR Heart Failure Study: NECTAR-HF.

De Ferrari GM, Tuinenburg AE, Ruble S, Brugada J, Klein H, Butter C, Wright DJ, Schubert B, Solomon S, Meyer S, Stein K, Ramuzat A, Zannad F - Eur. J. Heart Fail. (2014)

Bottom Line: Increased sympathetic activation and reduced parasympathetic tone are important pathophysiological contributors to the progression of heart failure, and are associated with poor outcome in patients.The study is powered to detect differences in the primary efficacy endpoint of change in left ventricular end systolic diameter.Secondary endpoints include ejection fraction, left ventricular volumes, quality of life scores, functional capacity, and changes in biomarkers.

View Article: PubMed Central - PubMed

Affiliation: Department of Cardiology, Fondazione IRCCS Policlinico San Matteo, Pavia, Italy.

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Related in: MedlinePlus

Study flow chart and data collection. CPET, cardiopulmonary exercise test; HF, heart failure; LVEDD, left ventricular end diastolic diameter; LVEF, left ventricular ejection fraction; NYHA, New York Heart Association; QOL, quality of life.
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fig03: Study flow chart and data collection. CPET, cardiopulmonary exercise test; HF, heart failure; LVEDD, left ventricular end diastolic diameter; LVEF, left ventricular ejection fraction; NYHA, New York Heart Association; QOL, quality of life.

Mentions: Figure3 shows the flow of the study visits.


Rationale and study design of the NEuroCardiac TherApy foR Heart Failure Study: NECTAR-HF.

De Ferrari GM, Tuinenburg AE, Ruble S, Brugada J, Klein H, Butter C, Wright DJ, Schubert B, Solomon S, Meyer S, Stein K, Ramuzat A, Zannad F - Eur. J. Heart Fail. (2014)

Study flow chart and data collection. CPET, cardiopulmonary exercise test; HF, heart failure; LVEDD, left ventricular end diastolic diameter; LVEF, left ventricular ejection fraction; NYHA, New York Heart Association; QOL, quality of life.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4288987&req=5

fig03: Study flow chart and data collection. CPET, cardiopulmonary exercise test; HF, heart failure; LVEDD, left ventricular end diastolic diameter; LVEF, left ventricular ejection fraction; NYHA, New York Heart Association; QOL, quality of life.
Mentions: Figure3 shows the flow of the study visits.

Bottom Line: Increased sympathetic activation and reduced parasympathetic tone are important pathophysiological contributors to the progression of heart failure, and are associated with poor outcome in patients.The study is powered to detect differences in the primary efficacy endpoint of change in left ventricular end systolic diameter.Secondary endpoints include ejection fraction, left ventricular volumes, quality of life scores, functional capacity, and changes in biomarkers.

View Article: PubMed Central - PubMed

Affiliation: Department of Cardiology, Fondazione IRCCS Policlinico San Matteo, Pavia, Italy.

Show MeSH
Related in: MedlinePlus