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Genetic factors may play a prominent role in the development of coronary heart disease dependent on important environmental factors.

Song C, Chang Z, Magnusson PK, Ingelsson E, Pedersen NL - J. Intern. Med. (2014)

Bottom Line: Smoking, sedentary lifestyle and above average BMI were significantly associated with increased CHD incidence.The heritability of CHD decreased with increasing age, as well as with increasing levels of BMI, in both men and women.Increased knowledge of gene-environment interactions will be important for a full understanding of the aetiology of CHD.

View Article: PubMed Central - PubMed

Affiliation: Department of Medical Epidemiology and Biostatistics, Karolinska Institute, Stockholm, Sweden; Department of Medical Sciences, Molecular Epidemiology and Science for Life Laboratory, Uppsala University, Uppsala, Sweden.

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Variance components of CHD as a function of BMI in men. Genetic (A) and nonshared environmental (E) variance components of CHD versus BMI at the mean age at baseline are shown. Heritability of CHD, as a proportion of the total variance, is shown for BMI values of 17, 25 and 33 kg m−2. BMI, body mass index; CHD, coronary heart disease.
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fig02: Variance components of CHD as a function of BMI in men. Genetic (A) and nonshared environmental (E) variance components of CHD versus BMI at the mean age at baseline are shown. Heritability of CHD, as a proportion of the total variance, is shown for BMI values of 17, 25 and 33 kg m−2. BMI, body mass index; CHD, coronary heart disease.

Mentions: Because BMI is correlated with age, which also moderates genetic variance of CHD (Fig.1 and Table4), we performed additional analyses allowing both age and BMI to moderate the AE components of CHD variance. Again, both genetic and nonshared environmental variance of CHD were greater in older age (Table S3) and lower with higher BMI (statistically significant only in men). Heritability of CHD decreased with increasing BMI. The effect of BMI on AE components and heritability at the mean baseline age (40 years) in men is shown in Fig.2. The same pattern was observed across the age groups (data not shown).


Genetic factors may play a prominent role in the development of coronary heart disease dependent on important environmental factors.

Song C, Chang Z, Magnusson PK, Ingelsson E, Pedersen NL - J. Intern. Med. (2014)

Variance components of CHD as a function of BMI in men. Genetic (A) and nonshared environmental (E) variance components of CHD versus BMI at the mean age at baseline are shown. Heritability of CHD, as a proportion of the total variance, is shown for BMI values of 17, 25 and 33 kg m−2. BMI, body mass index; CHD, coronary heart disease.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4288985&req=5

fig02: Variance components of CHD as a function of BMI in men. Genetic (A) and nonshared environmental (E) variance components of CHD versus BMI at the mean age at baseline are shown. Heritability of CHD, as a proportion of the total variance, is shown for BMI values of 17, 25 and 33 kg m−2. BMI, body mass index; CHD, coronary heart disease.
Mentions: Because BMI is correlated with age, which also moderates genetic variance of CHD (Fig.1 and Table4), we performed additional analyses allowing both age and BMI to moderate the AE components of CHD variance. Again, both genetic and nonshared environmental variance of CHD were greater in older age (Table S3) and lower with higher BMI (statistically significant only in men). Heritability of CHD decreased with increasing BMI. The effect of BMI on AE components and heritability at the mean baseline age (40 years) in men is shown in Fig.2. The same pattern was observed across the age groups (data not shown).

Bottom Line: Smoking, sedentary lifestyle and above average BMI were significantly associated with increased CHD incidence.The heritability of CHD decreased with increasing age, as well as with increasing levels of BMI, in both men and women.Increased knowledge of gene-environment interactions will be important for a full understanding of the aetiology of CHD.

View Article: PubMed Central - PubMed

Affiliation: Department of Medical Epidemiology and Biostatistics, Karolinska Institute, Stockholm, Sweden; Department of Medical Sciences, Molecular Epidemiology and Science for Life Laboratory, Uppsala University, Uppsala, Sweden.

Show MeSH
Related in: MedlinePlus