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Genetic factors may play a prominent role in the development of coronary heart disease dependent on important environmental factors.

Song C, Chang Z, Magnusson PK, Ingelsson E, Pedersen NL - J. Intern. Med. (2014)

Bottom Line: Smoking, sedentary lifestyle and above average BMI were significantly associated with increased CHD incidence.The heritability of CHD decreased with increasing age, as well as with increasing levels of BMI, in both men and women.Increased knowledge of gene-environment interactions will be important for a full understanding of the aetiology of CHD.

View Article: PubMed Central - PubMed

Affiliation: Department of Medical Epidemiology and Biostatistics, Karolinska Institute, Stockholm, Sweden; Department of Medical Sciences, Molecular Epidemiology and Science for Life Laboratory, Uppsala University, Uppsala, Sweden.

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Genetic variance (A), nonshared environmental variance (E) and heritability of CHD as a function of age in men (a) and women (b). Each unit on the x-axis represents age. Heritability of CHD, as a proportion of the total variance, is shown in the figure for selected ages (40, 50, 60, 70 and 80 years). CHD, coronary heart disease.
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fig01: Genetic variance (A), nonshared environmental variance (E) and heritability of CHD as a function of age in men (a) and women (b). Each unit on the x-axis represents age. Heritability of CHD, as a proportion of the total variance, is shown in the figure for selected ages (40, 50, 60, 70 and 80 years). CHD, coronary heart disease.

Mentions: Next, we investigated whether age moderated the AE components of CHD variance. Both genetic and nonshared environmental variance components increased across the age groups (Fig.1). However, the increase in total variance across age groups was explained by greater increases in environmental variance. Thus, expressed as a proportion of total variance, heritability decreased with increasing age.


Genetic factors may play a prominent role in the development of coronary heart disease dependent on important environmental factors.

Song C, Chang Z, Magnusson PK, Ingelsson E, Pedersen NL - J. Intern. Med. (2014)

Genetic variance (A), nonshared environmental variance (E) and heritability of CHD as a function of age in men (a) and women (b). Each unit on the x-axis represents age. Heritability of CHD, as a proportion of the total variance, is shown in the figure for selected ages (40, 50, 60, 70 and 80 years). CHD, coronary heart disease.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4288985&req=5

fig01: Genetic variance (A), nonshared environmental variance (E) and heritability of CHD as a function of age in men (a) and women (b). Each unit on the x-axis represents age. Heritability of CHD, as a proportion of the total variance, is shown in the figure for selected ages (40, 50, 60, 70 and 80 years). CHD, coronary heart disease.
Mentions: Next, we investigated whether age moderated the AE components of CHD variance. Both genetic and nonshared environmental variance components increased across the age groups (Fig.1). However, the increase in total variance across age groups was explained by greater increases in environmental variance. Thus, expressed as a proportion of total variance, heritability decreased with increasing age.

Bottom Line: Smoking, sedentary lifestyle and above average BMI were significantly associated with increased CHD incidence.The heritability of CHD decreased with increasing age, as well as with increasing levels of BMI, in both men and women.Increased knowledge of gene-environment interactions will be important for a full understanding of the aetiology of CHD.

View Article: PubMed Central - PubMed

Affiliation: Department of Medical Epidemiology and Biostatistics, Karolinska Institute, Stockholm, Sweden; Department of Medical Sciences, Molecular Epidemiology and Science for Life Laboratory, Uppsala University, Uppsala, Sweden.

Show MeSH
Related in: MedlinePlus