Modeling of time dependent localized flow shear stress and its impact on cellular growth within additive manufactured titanium implants.
Bottom Line: The model's effectiveness is demonstrated for two additive manufactured (AM) titanium scaffold architectures.The results demonstrate that there is a complex interaction of flow rate and strut architecture, resulting in partially randomized structures having a preferential impact on stimulating cell migration in 3D porous structures for higher flow rates.This novel result demonstrates the potential new insights that can be gained via the modeling tool developed, and how the model can be used to perform what-if simulations to design AM structures to specific functional requirements.
Affiliation: Department of Materials, Imperial College London, London, SW7 2AZ, UK.Show MeSH
Related in: MedlinePlus
Mentions: The comparison of overall growth rate (calculated by averaging the growth rates at all the time points) for regular and randomized structures is shown in Figure 8. It suggests that at velocities greater than 0.5 mm/s, randomized structure exhibits a generally better performance of cellular growth under the prevalence of the fluid flow induced shear stress.
Affiliation: Department of Materials, Imperial College London, London, SW7 2AZ, UK.