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Modeling of time dependent localized flow shear stress and its impact on cellular growth within additive manufactured titanium implants.

Zhang Z, Yuan L, Lee PD, Jones E, Jones JR - J. Biomed. Mater. Res. Part B Appl. Biomater. (2014)

Bottom Line: The model's effectiveness is demonstrated for two additive manufactured (AM) titanium scaffold architectures.The results demonstrate that there is a complex interaction of flow rate and strut architecture, resulting in partially randomized structures having a preferential impact on stimulating cell migration in 3D porous structures for higher flow rates.This novel result demonstrates the potential new insights that can be gained via the modeling tool developed, and how the model can be used to perform what-if simulations to design AM structures to specific functional requirements.

View Article: PubMed Central - PubMed

Affiliation: Department of Materials, Imperial College London, London, SW7 2AZ, UK.

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Comparison between the regular and 30% randomized structures: overall growth rate (average value at different time points) versus inflow velocity (without maximum shear constraint). Inset: I, II, III, and IV showing final growth in the regular structure; i, ii, iii, and iv showing the final growth in the randomized structure. Contour colored by shear stress. [Color figure can be viewed in the online issue, which is available at http://wileyonlinelibrary.com.]
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fig08: Comparison between the regular and 30% randomized structures: overall growth rate (average value at different time points) versus inflow velocity (without maximum shear constraint). Inset: I, II, III, and IV showing final growth in the regular structure; i, ii, iii, and iv showing the final growth in the randomized structure. Contour colored by shear stress. [Color figure can be viewed in the online issue, which is available at http://wileyonlinelibrary.com.]

Mentions: The comparison of overall growth rate (calculated by averaging the growth rates at all the time points) for regular and randomized structures is shown in Figure 8. It suggests that at velocities greater than 0.5 mm/s, randomized structure exhibits a generally better performance of cellular growth under the prevalence of the fluid flow induced shear stress.


Modeling of time dependent localized flow shear stress and its impact on cellular growth within additive manufactured titanium implants.

Zhang Z, Yuan L, Lee PD, Jones E, Jones JR - J. Biomed. Mater. Res. Part B Appl. Biomater. (2014)

Comparison between the regular and 30% randomized structures: overall growth rate (average value at different time points) versus inflow velocity (without maximum shear constraint). Inset: I, II, III, and IV showing final growth in the regular structure; i, ii, iii, and iv showing the final growth in the randomized structure. Contour colored by shear stress. [Color figure can be viewed in the online issue, which is available at http://wileyonlinelibrary.com.]
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4288932&req=5

fig08: Comparison between the regular and 30% randomized structures: overall growth rate (average value at different time points) versus inflow velocity (without maximum shear constraint). Inset: I, II, III, and IV showing final growth in the regular structure; i, ii, iii, and iv showing the final growth in the randomized structure. Contour colored by shear stress. [Color figure can be viewed in the online issue, which is available at http://wileyonlinelibrary.com.]
Mentions: The comparison of overall growth rate (calculated by averaging the growth rates at all the time points) for regular and randomized structures is shown in Figure 8. It suggests that at velocities greater than 0.5 mm/s, randomized structure exhibits a generally better performance of cellular growth under the prevalence of the fluid flow induced shear stress.

Bottom Line: The model's effectiveness is demonstrated for two additive manufactured (AM) titanium scaffold architectures.The results demonstrate that there is a complex interaction of flow rate and strut architecture, resulting in partially randomized structures having a preferential impact on stimulating cell migration in 3D porous structures for higher flow rates.This novel result demonstrates the potential new insights that can be gained via the modeling tool developed, and how the model can be used to perform what-if simulations to design AM structures to specific functional requirements.

View Article: PubMed Central - PubMed

Affiliation: Department of Materials, Imperial College London, London, SW7 2AZ, UK.

Show MeSH
Related in: MedlinePlus