Modeling of time dependent localized flow shear stress and its impact on cellular growth within additive manufactured titanium implants.
Bottom Line: The model's effectiveness is demonstrated for two additive manufactured (AM) titanium scaffold architectures.The results demonstrate that there is a complex interaction of flow rate and strut architecture, resulting in partially randomized structures having a preferential impact on stimulating cell migration in 3D porous structures for higher flow rates.This novel result demonstrates the potential new insights that can be gained via the modeling tool developed, and how the model can be used to perform what-if simulations to design AM structures to specific functional requirements.
Affiliation: Department of Materials, Imperial College London, London, SW7 2AZ, UK.Show MeSH
Related in: MedlinePlus
Mentions: The comparison of the total volume fraction of cellular growth without constraints in both structures is shown in Figure 7 as a function of the average local shear stress. Both regular and 30% randomized structures show similar growth at inflow velocities less than 0.1 mm/s; however by looking at the shear distributions in the 3D structures, factors which may hinder the growth in the regular and randomized structure appear differently, and are discussed in the following section. At an inflow velocity of 0.2 mm/s, after 9% of channel volume is occupied by new grown tissue, the regular structure experiences higher shear stress and shows less increase in bone volume fraction when compared to the randomized structure.
Affiliation: Department of Materials, Imperial College London, London, SW7 2AZ, UK.