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Modeling of time dependent localized flow shear stress and its impact on cellular growth within additive manufactured titanium implants.

Zhang Z, Yuan L, Lee PD, Jones E, Jones JR - J. Biomed. Mater. Res. Part B Appl. Biomater. (2014)

Bottom Line: The model's effectiveness is demonstrated for two additive manufactured (AM) titanium scaffold architectures.The results demonstrate that there is a complex interaction of flow rate and strut architecture, resulting in partially randomized structures having a preferential impact on stimulating cell migration in 3D porous structures for higher flow rates.This novel result demonstrates the potential new insights that can be gained via the modeling tool developed, and how the model can be used to perform what-if simulations to design AM structures to specific functional requirements.

View Article: PubMed Central - PubMed

Affiliation: Department of Materials, Imperial College London, London, SW7 2AZ, UK.

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Related in: MedlinePlus

Comparison between the regular and 30% randomized structures at final stage of growth: volume fraction of cellular growth vs. average shear stress at different flow inlet velocities (without shear constraint).
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fig07: Comparison between the regular and 30% randomized structures at final stage of growth: volume fraction of cellular growth vs. average shear stress at different flow inlet velocities (without shear constraint).

Mentions: The comparison of the total volume fraction of cellular growth without constraints in both structures is shown in Figure 7 as a function of the average local shear stress. Both regular and 30% randomized structures show similar growth at inflow velocities less than 0.1 mm/s; however by looking at the shear distributions in the 3D structures, factors which may hinder the growth in the regular and randomized structure appear differently, and are discussed in the following section. At an inflow velocity of 0.2 mm/s, after 9% of channel volume is occupied by new grown tissue, the regular structure experiences higher shear stress and shows less increase in bone volume fraction when compared to the randomized structure.


Modeling of time dependent localized flow shear stress and its impact on cellular growth within additive manufactured titanium implants.

Zhang Z, Yuan L, Lee PD, Jones E, Jones JR - J. Biomed. Mater. Res. Part B Appl. Biomater. (2014)

Comparison between the regular and 30% randomized structures at final stage of growth: volume fraction of cellular growth vs. average shear stress at different flow inlet velocities (without shear constraint).
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4288932&req=5

fig07: Comparison between the regular and 30% randomized structures at final stage of growth: volume fraction of cellular growth vs. average shear stress at different flow inlet velocities (without shear constraint).
Mentions: The comparison of the total volume fraction of cellular growth without constraints in both structures is shown in Figure 7 as a function of the average local shear stress. Both regular and 30% randomized structures show similar growth at inflow velocities less than 0.1 mm/s; however by looking at the shear distributions in the 3D structures, factors which may hinder the growth in the regular and randomized structure appear differently, and are discussed in the following section. At an inflow velocity of 0.2 mm/s, after 9% of channel volume is occupied by new grown tissue, the regular structure experiences higher shear stress and shows less increase in bone volume fraction when compared to the randomized structure.

Bottom Line: The model's effectiveness is demonstrated for two additive manufactured (AM) titanium scaffold architectures.The results demonstrate that there is a complex interaction of flow rate and strut architecture, resulting in partially randomized structures having a preferential impact on stimulating cell migration in 3D porous structures for higher flow rates.This novel result demonstrates the potential new insights that can be gained via the modeling tool developed, and how the model can be used to perform what-if simulations to design AM structures to specific functional requirements.

View Article: PubMed Central - PubMed

Affiliation: Department of Materials, Imperial College London, London, SW7 2AZ, UK.

Show MeSH
Related in: MedlinePlus