Modeling of time dependent localized flow shear stress and its impact on cellular growth within additive manufactured titanium implants.
Bottom Line: The model's effectiveness is demonstrated for two additive manufactured (AM) titanium scaffold architectures.The results demonstrate that there is a complex interaction of flow rate and strut architecture, resulting in partially randomized structures having a preferential impact on stimulating cell migration in 3D porous structures for higher flow rates.This novel result demonstrates the potential new insights that can be gained via the modeling tool developed, and how the model can be used to perform what-if simulations to design AM structures to specific functional requirements.
Affiliation: Department of Materials, Imperial College London, London, SW7 2AZ, UK.Show MeSH
Related in: MedlinePlus
Mentions: A comparative plot of volume fraction occupied by cells over time in the two structures is shown in Figure 6(a). A tenfold increase in inflow velocities causes a nine times increase in cellular growth (1.9–17.5%) in the regular structure after 120 h while in the randomized structure, cellular growth is initially similar for all inflow velocities, but after 60 h, it shows a faster migration with a 11.5 times increase in bone volume (1.7–19.5%).
Affiliation: Department of Materials, Imperial College London, London, SW7 2AZ, UK.