Modeling of time dependent localized flow shear stress and its impact on cellular growth within additive manufactured titanium implants.
Bottom Line: The model's effectiveness is demonstrated for two additive manufactured (AM) titanium scaffold architectures.The results demonstrate that there is a complex interaction of flow rate and strut architecture, resulting in partially randomized structures having a preferential impact on stimulating cell migration in 3D porous structures for higher flow rates.This novel result demonstrates the potential new insights that can be gained via the modeling tool developed, and how the model can be used to perform what-if simulations to design AM structures to specific functional requirements.
Affiliation: Department of Materials, Imperial College London, London, SW7 2AZ, UK.Show MeSH
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Mentions: The distributions of local shear stress throughout the regular and randomized implants are shown in Figure 5 as fluid volume normalized histograms. Shear stress values corresponding to all the interfacial cells are counted and normalized by the total fluid volume. Five key parameters are extracted in Table 2: the mean, standard deviation of shear stress and the mode, skew and kurtosis of the distribution at both early and final growth stages. The strong influence of inflow velocity and strut structure on local shear stress is clearly shown. In the regular structure, more local cells have higher shear stress with the increase of inlet velocity. This trend is also shown for the randomized structure. However, in the 30% randomized structure, both the shifts in modal values of the shear stress from 2.6 to 71.1 mPa at early stage and 5.8 to 71.1 mPa at final stage reveal greater ranges than those in the regular structure [(Figure 5(b)].
Affiliation: Department of Materials, Imperial College London, London, SW7 2AZ, UK.