Modeling of time dependent localized flow shear stress and its impact on cellular growth within additive manufactured titanium implants.
Bottom Line: The model's effectiveness is demonstrated for two additive manufactured (AM) titanium scaffold architectures.The results demonstrate that there is a complex interaction of flow rate and strut architecture, resulting in partially randomized structures having a preferential impact on stimulating cell migration in 3D porous structures for higher flow rates.This novel result demonstrates the potential new insights that can be gained via the modeling tool developed, and how the model can be used to perform what-if simulations to design AM structures to specific functional requirements.
Affiliation: Department of Materials, Imperial College London, London, SW7 2AZ, UK.Show MeSH
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Mentions: The overall pressure drop in both implant structures at inflow velocity of 0.02 mm/s are shown in Figure 3. Pressure in the 3D volume of the regular design (0% randomization) varies from 0 to 1.5 mPa. Simulation in the 30% randomized structure reveals a maximum pressure variation 2.4 times greater than the regular due to the uneven distribution of velocities of fluid passing through more torturous channels.
Affiliation: Department of Materials, Imperial College London, London, SW7 2AZ, UK.