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Measuring brain atrophy with a generalized formulation of the boundary shift integral.

Prados F, Cardoso MJ, Leung KK, Cash DM, Modat M, Fox NC, Wheeler-Kingshott CA, Ourselin S, Alzheimer's Disease Neuroimaging Initiati - Neurobiol. Aging (2014)

Bottom Line: Brain atrophy measured using structural magnetic resonance imaging (MRI) has been widely used as an imaging biomarker for disease diagnosis and tracking of pathologic progression in neurodegenerative diseases.In this work, we present a generalized and extended formulation of the boundary shift integral (gBSI) using probabilistic segmentations to estimate anatomic changes between 2 time points.This method adaptively estimates a non-binary exclusive OR region of interest from probabilistic brain segmentations of the baseline and repeat scans to better localize and capture the brain atrophy.

View Article: PubMed Central - PubMed

Affiliation: Centre for Medical Image Computing (CMIC), Department of Medical Physics and Bioengineering, University College London, London, UK; NMR Research Unit, Queen Square MS Centre, Department of Neuroinflammation, UCL Institute of Neurology, London, UK. Electronic address: f.carrasco@ucl.ac.uk.

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Diagram representing manual-KN-BSI, STEPS-KN-BSI, pBSI, and gBSI processing pipelines. Abbreviations: BSI, boundary shift integral; gBSI, generalized boundary shift integral.
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fig6: Diagram representing manual-KN-BSI, STEPS-KN-BSI, pBSI, and gBSI processing pipelines. Abbreviations: BSI, boundary shift integral; gBSI, generalized boundary shift integral.


Measuring brain atrophy with a generalized formulation of the boundary shift integral.

Prados F, Cardoso MJ, Leung KK, Cash DM, Modat M, Fox NC, Wheeler-Kingshott CA, Ourselin S, Alzheimer's Disease Neuroimaging Initiati - Neurobiol. Aging (2014)

Diagram representing manual-KN-BSI, STEPS-KN-BSI, pBSI, and gBSI processing pipelines. Abbreviations: BSI, boundary shift integral; gBSI, generalized boundary shift integral.
© Copyright Policy - CC BY
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4288791&req=5

fig6: Diagram representing manual-KN-BSI, STEPS-KN-BSI, pBSI, and gBSI processing pipelines. Abbreviations: BSI, boundary shift integral; gBSI, generalized boundary shift integral.
Bottom Line: Brain atrophy measured using structural magnetic resonance imaging (MRI) has been widely used as an imaging biomarker for disease diagnosis and tracking of pathologic progression in neurodegenerative diseases.In this work, we present a generalized and extended formulation of the boundary shift integral (gBSI) using probabilistic segmentations to estimate anatomic changes between 2 time points.This method adaptively estimates a non-binary exclusive OR region of interest from probabilistic brain segmentations of the baseline and repeat scans to better localize and capture the brain atrophy.

View Article: PubMed Central - PubMed

Affiliation: Centre for Medical Image Computing (CMIC), Department of Medical Physics and Bioengineering, University College London, London, UK; NMR Research Unit, Queen Square MS Centre, Department of Neuroinflammation, UCL Institute of Neurology, London, UK. Electronic address: f.carrasco@ucl.ac.uk.

Show MeSH
Related in: MedlinePlus