Limits...
Effect of low birth weight on childhood asthma: a meta-analysis.

Xu XF, Li YJ, Sheng YJ, Liu JL, Tang LF, Chen ZM - BMC Pediatr (2014)

Bottom Line: In stratified analyses, the effect of low birth weight on childhood asthma was strong, particularly in studies conducted in Europe, those with a small sample size, and those published recently.A meta-regression analysis did not find significant determinants.This meta-analysis shows that low birth weight significantly increases the risk of childhood asthma.

View Article: PubMed Central - PubMed

Affiliation: Department of Pulmonology, The Children's Hospital, Zhejiang University School of Medicine, Hangzhou 310003, China. drchenzm@163.com.

ABSTRACT

Background: Low birth weight is strongly correlated with an increased risk of adult diseases. Additionally, low birth weight might be a risk factor for asthma later in life.

Methods: A systematic literature search of the PubMed database from 1966 to November 2013 was conducted. The criteria for inclusion of papers were as follows: case-control or cohort studies; the odds ratio (OR) or risk ratio (RR) estimates with the corresponding 95% confidence intervals (CIs) were presented, or there were sufficient data for calculation; and studies were published in English up to October 2013. Random-effect and fixed-effect meta-analyses, meta-regression, and cumulative meta-analysis were conducted.

Results: Thirteen cohort studies and 1,105,703 subjects were included. The overall pooled RRs (95% CIs) of asthma risk for low birth weight were 1.162 (fixed-effects model, 95% CI, 1.128-1.197) and 1.152 (random-effects model, 95% CI, 1.082-1.222). In stratified analyses, the effect of low birth weight on childhood asthma was strong, particularly in studies conducted in Europe, those with a small sample size, and those published recently. A meta-regression analysis did not find significant determinants.

Conclusions: This meta-analysis shows that low birth weight significantly increases the risk of childhood asthma.

No MeSH data available.


Related in: MedlinePlus

Funnel plot of the effect estimates (log RR) by their SE (standard error of log RR). The vertical line indicates the summary effect estimate and the corresponding pseudo 95% confidence limits converging as a function of the SE of the effect estimate.
© Copyright Policy - open-access
Related In: Results  -  Collection

License 1 - License 2
getmorefigures.php?uid=PMC4288645&req=5

Fig5: Funnel plot of the effect estimates (log RR) by their SE (standard error of log RR). The vertical line indicates the summary effect estimate and the corresponding pseudo 95% confidence limits converging as a function of the SE of the effect estimate.

Mentions: We assessed the potential publication bias by using a funnel plot (Figure 5). The funnel plots did not show any remarkable asymmetry. Additionally, Egger’s and Begg’s tests showed no evident publication bias. P values for the two tests were 0.653 and 0.951, respectively.Figure 5


Effect of low birth weight on childhood asthma: a meta-analysis.

Xu XF, Li YJ, Sheng YJ, Liu JL, Tang LF, Chen ZM - BMC Pediatr (2014)

Funnel plot of the effect estimates (log RR) by their SE (standard error of log RR). The vertical line indicates the summary effect estimate and the corresponding pseudo 95% confidence limits converging as a function of the SE of the effect estimate.
© Copyright Policy - open-access
Related In: Results  -  Collection

License 1 - License 2
Show All Figures
getmorefigures.php?uid=PMC4288645&req=5

Fig5: Funnel plot of the effect estimates (log RR) by their SE (standard error of log RR). The vertical line indicates the summary effect estimate and the corresponding pseudo 95% confidence limits converging as a function of the SE of the effect estimate.
Mentions: We assessed the potential publication bias by using a funnel plot (Figure 5). The funnel plots did not show any remarkable asymmetry. Additionally, Egger’s and Begg’s tests showed no evident publication bias. P values for the two tests were 0.653 and 0.951, respectively.Figure 5

Bottom Line: In stratified analyses, the effect of low birth weight on childhood asthma was strong, particularly in studies conducted in Europe, those with a small sample size, and those published recently.A meta-regression analysis did not find significant determinants.This meta-analysis shows that low birth weight significantly increases the risk of childhood asthma.

View Article: PubMed Central - PubMed

Affiliation: Department of Pulmonology, The Children's Hospital, Zhejiang University School of Medicine, Hangzhou 310003, China. drchenzm@163.com.

ABSTRACT

Background: Low birth weight is strongly correlated with an increased risk of adult diseases. Additionally, low birth weight might be a risk factor for asthma later in life.

Methods: A systematic literature search of the PubMed database from 1966 to November 2013 was conducted. The criteria for inclusion of papers were as follows: case-control or cohort studies; the odds ratio (OR) or risk ratio (RR) estimates with the corresponding 95% confidence intervals (CIs) were presented, or there were sufficient data for calculation; and studies were published in English up to October 2013. Random-effect and fixed-effect meta-analyses, meta-regression, and cumulative meta-analysis were conducted.

Results: Thirteen cohort studies and 1,105,703 subjects were included. The overall pooled RRs (95% CIs) of asthma risk for low birth weight were 1.162 (fixed-effects model, 95% CI, 1.128-1.197) and 1.152 (random-effects model, 95% CI, 1.082-1.222). In stratified analyses, the effect of low birth weight on childhood asthma was strong, particularly in studies conducted in Europe, those with a small sample size, and those published recently. A meta-regression analysis did not find significant determinants.

Conclusions: This meta-analysis shows that low birth weight significantly increases the risk of childhood asthma.

No MeSH data available.


Related in: MedlinePlus