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Effect of low birth weight on childhood asthma: a meta-analysis.

Xu XF, Li YJ, Sheng YJ, Liu JL, Tang LF, Chen ZM - BMC Pediatr (2014)

Bottom Line: In stratified analyses, the effect of low birth weight on childhood asthma was strong, particularly in studies conducted in Europe, those with a small sample size, and those published recently.A meta-regression analysis did not find significant determinants.This meta-analysis shows that low birth weight significantly increases the risk of childhood asthma.

View Article: PubMed Central - PubMed

Affiliation: Department of Pulmonology, The Children's Hospital, Zhejiang University School of Medicine, Hangzhou 310003, China. drchenzm@163.com.

ABSTRACT

Background: Low birth weight is strongly correlated with an increased risk of adult diseases. Additionally, low birth weight might be a risk factor for asthma later in life.

Methods: A systematic literature search of the PubMed database from 1966 to November 2013 was conducted. The criteria for inclusion of papers were as follows: case-control or cohort studies; the odds ratio (OR) or risk ratio (RR) estimates with the corresponding 95% confidence intervals (CIs) were presented, or there were sufficient data for calculation; and studies were published in English up to October 2013. Random-effect and fixed-effect meta-analyses, meta-regression, and cumulative meta-analysis were conducted.

Results: Thirteen cohort studies and 1,105,703 subjects were included. The overall pooled RRs (95% CIs) of asthma risk for low birth weight were 1.162 (fixed-effects model, 95% CI, 1.128-1.197) and 1.152 (random-effects model, 95% CI, 1.082-1.222). In stratified analyses, the effect of low birth weight on childhood asthma was strong, particularly in studies conducted in Europe, those with a small sample size, and those published recently. A meta-regression analysis did not find significant determinants.

Conclusions: This meta-analysis shows that low birth weight significantly increases the risk of childhood asthma.

No MeSH data available.


Related in: MedlinePlus

Cumulative meta-analysis. Each study was put into the pooled analysis one by one according to the publication year.
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Fig4: Cumulative meta-analysis. Each study was put into the pooled analysis one by one according to the publication year.

Mentions: Cumulative meta-analyses of all of the studies showed that the estimates gradually became consistent, and the corresponding CIs narrowed down in the order of publication year (FigureĀ 4). We also performed sensitivity analysis, and the pooled results did not appear to change.Table 3


Effect of low birth weight on childhood asthma: a meta-analysis.

Xu XF, Li YJ, Sheng YJ, Liu JL, Tang LF, Chen ZM - BMC Pediatr (2014)

Cumulative meta-analysis. Each study was put into the pooled analysis one by one according to the publication year.
© Copyright Policy - open-access
Related In: Results  -  Collection

License 1 - License 2
Show All Figures
getmorefigures.php?uid=PMC4288645&req=5

Fig4: Cumulative meta-analysis. Each study was put into the pooled analysis one by one according to the publication year.
Mentions: Cumulative meta-analyses of all of the studies showed that the estimates gradually became consistent, and the corresponding CIs narrowed down in the order of publication year (FigureĀ 4). We also performed sensitivity analysis, and the pooled results did not appear to change.Table 3

Bottom Line: In stratified analyses, the effect of low birth weight on childhood asthma was strong, particularly in studies conducted in Europe, those with a small sample size, and those published recently.A meta-regression analysis did not find significant determinants.This meta-analysis shows that low birth weight significantly increases the risk of childhood asthma.

View Article: PubMed Central - PubMed

Affiliation: Department of Pulmonology, The Children's Hospital, Zhejiang University School of Medicine, Hangzhou 310003, China. drchenzm@163.com.

ABSTRACT

Background: Low birth weight is strongly correlated with an increased risk of adult diseases. Additionally, low birth weight might be a risk factor for asthma later in life.

Methods: A systematic literature search of the PubMed database from 1966 to November 2013 was conducted. The criteria for inclusion of papers were as follows: case-control or cohort studies; the odds ratio (OR) or risk ratio (RR) estimates with the corresponding 95% confidence intervals (CIs) were presented, or there were sufficient data for calculation; and studies were published in English up to October 2013. Random-effect and fixed-effect meta-analyses, meta-regression, and cumulative meta-analysis were conducted.

Results: Thirteen cohort studies and 1,105,703 subjects were included. The overall pooled RRs (95% CIs) of asthma risk for low birth weight were 1.162 (fixed-effects model, 95% CI, 1.128-1.197) and 1.152 (random-effects model, 95% CI, 1.082-1.222). In stratified analyses, the effect of low birth weight on childhood asthma was strong, particularly in studies conducted in Europe, those with a small sample size, and those published recently. A meta-regression analysis did not find significant determinants.

Conclusions: This meta-analysis shows that low birth weight significantly increases the risk of childhood asthma.

No MeSH data available.


Related in: MedlinePlus