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Effect of low birth weight on childhood asthma: a meta-analysis.

Xu XF, Li YJ, Sheng YJ, Liu JL, Tang LF, Chen ZM - BMC Pediatr (2014)

Bottom Line: In stratified analyses, the effect of low birth weight on childhood asthma was strong, particularly in studies conducted in Europe, those with a small sample size, and those published recently.A meta-regression analysis did not find significant determinants.This meta-analysis shows that low birth weight significantly increases the risk of childhood asthma.

View Article: PubMed Central - PubMed

Affiliation: Department of Pulmonology, The Children's Hospital, Zhejiang University School of Medicine, Hangzhou 310003, China. drchenzm@163.com.

ABSTRACT

Background: Low birth weight is strongly correlated with an increased risk of adult diseases. Additionally, low birth weight might be a risk factor for asthma later in life.

Methods: A systematic literature search of the PubMed database from 1966 to November 2013 was conducted. The criteria for inclusion of papers were as follows: case-control or cohort studies; the odds ratio (OR) or risk ratio (RR) estimates with the corresponding 95% confidence intervals (CIs) were presented, or there were sufficient data for calculation; and studies were published in English up to October 2013. Random-effect and fixed-effect meta-analyses, meta-regression, and cumulative meta-analysis were conducted.

Results: Thirteen cohort studies and 1,105,703 subjects were included. The overall pooled RRs (95% CIs) of asthma risk for low birth weight were 1.162 (fixed-effects model, 95% CI, 1.128-1.197) and 1.152 (random-effects model, 95% CI, 1.082-1.222). In stratified analyses, the effect of low birth weight on childhood asthma was strong, particularly in studies conducted in Europe, those with a small sample size, and those published recently. A meta-regression analysis did not find significant determinants.

Conclusions: This meta-analysis shows that low birth weight significantly increases the risk of childhood asthma.

No MeSH data available.


Related in: MedlinePlus

Meta-analysis of the effect of low birth weight on childhood asthma, and forest plots stratified by geographic area.
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Fig2: Meta-analysis of the effect of low birth weight on childhood asthma, and forest plots stratified by geographic area.

Mentions: Five of the 13 estimates were directly from the original studies, and eight were transformed from the information available to comply with our categorization used in the meta-analysis. Figures 2 and 3 show forest plots, which provide study-specific and pooled RRs (95% CIs), of development of asthma for low birth weight. When compared with normal birth weight, the pooled RRs from the fixed-effects and random-effects models were 1.162 (95% CI, 1.128–1.197) and 1.152 (95%, 1.082–1.222) for low birth weight (I2 = 40.2%, P = 0.066), respectively. Both models showed similar summary effect estimates, indicating a significantly increased risk of asthma in relation to low birth weight. Table 2 shows the pooled RRs (95% CIs) among different subgroups stratified by five main characteristics of the studies. The subgroup analyses showed an even greater effect estimate in the six studies conducted in Europe compared with other geographic areas. Additionally, subgroup analyses showed a greater effect estimate in the eight studies with a small sample size (<5000 subjects) compared with those with a larger sample size, and a greater effect estimate in the seven recently published studies compared with those in the older six studies. The effect estimates stratified by study population age and adjusted RRs were similar to the overall pooled RRs.Figure 2


Effect of low birth weight on childhood asthma: a meta-analysis.

Xu XF, Li YJ, Sheng YJ, Liu JL, Tang LF, Chen ZM - BMC Pediatr (2014)

Meta-analysis of the effect of low birth weight on childhood asthma, and forest plots stratified by geographic area.
© Copyright Policy - open-access
Related In: Results  -  Collection

License 1 - License 2
Show All Figures
getmorefigures.php?uid=PMC4288645&req=5

Fig2: Meta-analysis of the effect of low birth weight on childhood asthma, and forest plots stratified by geographic area.
Mentions: Five of the 13 estimates were directly from the original studies, and eight were transformed from the information available to comply with our categorization used in the meta-analysis. Figures 2 and 3 show forest plots, which provide study-specific and pooled RRs (95% CIs), of development of asthma for low birth weight. When compared with normal birth weight, the pooled RRs from the fixed-effects and random-effects models were 1.162 (95% CI, 1.128–1.197) and 1.152 (95%, 1.082–1.222) for low birth weight (I2 = 40.2%, P = 0.066), respectively. Both models showed similar summary effect estimates, indicating a significantly increased risk of asthma in relation to low birth weight. Table 2 shows the pooled RRs (95% CIs) among different subgroups stratified by five main characteristics of the studies. The subgroup analyses showed an even greater effect estimate in the six studies conducted in Europe compared with other geographic areas. Additionally, subgroup analyses showed a greater effect estimate in the eight studies with a small sample size (<5000 subjects) compared with those with a larger sample size, and a greater effect estimate in the seven recently published studies compared with those in the older six studies. The effect estimates stratified by study population age and adjusted RRs were similar to the overall pooled RRs.Figure 2

Bottom Line: In stratified analyses, the effect of low birth weight on childhood asthma was strong, particularly in studies conducted in Europe, those with a small sample size, and those published recently.A meta-regression analysis did not find significant determinants.This meta-analysis shows that low birth weight significantly increases the risk of childhood asthma.

View Article: PubMed Central - PubMed

Affiliation: Department of Pulmonology, The Children's Hospital, Zhejiang University School of Medicine, Hangzhou 310003, China. drchenzm@163.com.

ABSTRACT

Background: Low birth weight is strongly correlated with an increased risk of adult diseases. Additionally, low birth weight might be a risk factor for asthma later in life.

Methods: A systematic literature search of the PubMed database from 1966 to November 2013 was conducted. The criteria for inclusion of papers were as follows: case-control or cohort studies; the odds ratio (OR) or risk ratio (RR) estimates with the corresponding 95% confidence intervals (CIs) were presented, or there were sufficient data for calculation; and studies were published in English up to October 2013. Random-effect and fixed-effect meta-analyses, meta-regression, and cumulative meta-analysis were conducted.

Results: Thirteen cohort studies and 1,105,703 subjects were included. The overall pooled RRs (95% CIs) of asthma risk for low birth weight were 1.162 (fixed-effects model, 95% CI, 1.128-1.197) and 1.152 (random-effects model, 95% CI, 1.082-1.222). In stratified analyses, the effect of low birth weight on childhood asthma was strong, particularly in studies conducted in Europe, those with a small sample size, and those published recently. A meta-regression analysis did not find significant determinants.

Conclusions: This meta-analysis shows that low birth weight significantly increases the risk of childhood asthma.

No MeSH data available.


Related in: MedlinePlus