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Effect of low birth weight on childhood asthma: a meta-analysis.

Xu XF, Li YJ, Sheng YJ, Liu JL, Tang LF, Chen ZM - BMC Pediatr (2014)

Bottom Line: In stratified analyses, the effect of low birth weight on childhood asthma was strong, particularly in studies conducted in Europe, those with a small sample size, and those published recently.A meta-regression analysis did not find significant determinants.This meta-analysis shows that low birth weight significantly increases the risk of childhood asthma.

View Article: PubMed Central - PubMed

Affiliation: Department of Pulmonology, The Children's Hospital, Zhejiang University School of Medicine, Hangzhou 310003, China. drchenzm@163.com.

ABSTRACT

Background: Low birth weight is strongly correlated with an increased risk of adult diseases. Additionally, low birth weight might be a risk factor for asthma later in life.

Methods: A systematic literature search of the PubMed database from 1966 to November 2013 was conducted. The criteria for inclusion of papers were as follows: case-control or cohort studies; the odds ratio (OR) or risk ratio (RR) estimates with the corresponding 95% confidence intervals (CIs) were presented, or there were sufficient data for calculation; and studies were published in English up to October 2013. Random-effect and fixed-effect meta-analyses, meta-regression, and cumulative meta-analysis were conducted.

Results: Thirteen cohort studies and 1,105,703 subjects were included. The overall pooled RRs (95% CIs) of asthma risk for low birth weight were 1.162 (fixed-effects model, 95% CI, 1.128-1.197) and 1.152 (random-effects model, 95% CI, 1.082-1.222). In stratified analyses, the effect of low birth weight on childhood asthma was strong, particularly in studies conducted in Europe, those with a small sample size, and those published recently. A meta-regression analysis did not find significant determinants.

Conclusions: This meta-analysis shows that low birth weight significantly increases the risk of childhood asthma.

No MeSH data available.


Related in: MedlinePlus

Flow diagram for the selection of studies: article search strategy results.
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Fig1: Flow diagram for the selection of studies: article search strategy results.

Mentions: A description of the search process is shown in Figure 1. Of the 692 papers found by the search, 13 cohort studies met the inclusion criteria and were included [14–26]. Among these, only five studies provided the adjusted effect estimates of low birth weight versus childhood asthma [14–16, 22, 23]. Of the 13 cohort studies selected, 11 were published in 2000–2013, and two were published in 1997 and 1998. The majority of the cohorts (n = 6) were in Europe (Denmark, Finland, Germany, Sweden, and the United Kingdom) [14, 16, 20, 21, 24, 26]. Four cohorts were studied in North America (US and Canada) [19, 22, 23, 25], one in Oceania (New Zealand) [17], one in South America (Brazil) [15], and one in Asia (Taiwan) [18]. Detailed characteristics of the studies that were included are shown in Table 1.Figure 1


Effect of low birth weight on childhood asthma: a meta-analysis.

Xu XF, Li YJ, Sheng YJ, Liu JL, Tang LF, Chen ZM - BMC Pediatr (2014)

Flow diagram for the selection of studies: article search strategy results.
© Copyright Policy - open-access
Related In: Results  -  Collection

License 1 - License 2
Show All Figures
getmorefigures.php?uid=PMC4288645&req=5

Fig1: Flow diagram for the selection of studies: article search strategy results.
Mentions: A description of the search process is shown in Figure 1. Of the 692 papers found by the search, 13 cohort studies met the inclusion criteria and were included [14–26]. Among these, only five studies provided the adjusted effect estimates of low birth weight versus childhood asthma [14–16, 22, 23]. Of the 13 cohort studies selected, 11 were published in 2000–2013, and two were published in 1997 and 1998. The majority of the cohorts (n = 6) were in Europe (Denmark, Finland, Germany, Sweden, and the United Kingdom) [14, 16, 20, 21, 24, 26]. Four cohorts were studied in North America (US and Canada) [19, 22, 23, 25], one in Oceania (New Zealand) [17], one in South America (Brazil) [15], and one in Asia (Taiwan) [18]. Detailed characteristics of the studies that were included are shown in Table 1.Figure 1

Bottom Line: In stratified analyses, the effect of low birth weight on childhood asthma was strong, particularly in studies conducted in Europe, those with a small sample size, and those published recently.A meta-regression analysis did not find significant determinants.This meta-analysis shows that low birth weight significantly increases the risk of childhood asthma.

View Article: PubMed Central - PubMed

Affiliation: Department of Pulmonology, The Children's Hospital, Zhejiang University School of Medicine, Hangzhou 310003, China. drchenzm@163.com.

ABSTRACT

Background: Low birth weight is strongly correlated with an increased risk of adult diseases. Additionally, low birth weight might be a risk factor for asthma later in life.

Methods: A systematic literature search of the PubMed database from 1966 to November 2013 was conducted. The criteria for inclusion of papers were as follows: case-control or cohort studies; the odds ratio (OR) or risk ratio (RR) estimates with the corresponding 95% confidence intervals (CIs) were presented, or there were sufficient data for calculation; and studies were published in English up to October 2013. Random-effect and fixed-effect meta-analyses, meta-regression, and cumulative meta-analysis were conducted.

Results: Thirteen cohort studies and 1,105,703 subjects were included. The overall pooled RRs (95% CIs) of asthma risk for low birth weight were 1.162 (fixed-effects model, 95% CI, 1.128-1.197) and 1.152 (random-effects model, 95% CI, 1.082-1.222). In stratified analyses, the effect of low birth weight on childhood asthma was strong, particularly in studies conducted in Europe, those with a small sample size, and those published recently. A meta-regression analysis did not find significant determinants.

Conclusions: This meta-analysis shows that low birth weight significantly increases the risk of childhood asthma.

No MeSH data available.


Related in: MedlinePlus