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The severity of irritable bowel syndrome or the presence of fibromyalgia influencing the perception of visceral and somatic stimuli.

Tremolaterra F, Gallotta S, Morra Y, Lubrano E, Ciacci C, Iovino P - BMC Gastroenterol (2014)

Bottom Line: Mild and severe IBS patients without FMS demonstrated a significantly lower somatic perception cumulative score than severe IBS patients with FMS at active site.Conversely only severe IBS patients without FMS had significantly lower visceral thresholds for discomfort than mild IBS patients and severe IBS patients with FMS.The presence of co-existing FMS or greater FBDSI affects somatic and visceral perception in a graded fashion across IBS patients.

View Article: PubMed Central - PubMed

Affiliation: Gastrointestinal Unit, Department of Medicine and Surgery, University of Salerno, Via S, Allende, 84081 Baronissi, SA, Italy. piovino@unisa.it.

ABSTRACT

Background: Fibromyalgia Syndrome (FMS) is a frequent comorbidity in Irritable Bowel Syndrome (IBS) patients with a higher functional bowel disorder severity index (FBDSI). We tested the possibility that mild to severe IBS patients without FMS would have a graduated visceral and somatic perception, and the presence of FMS would further enhance somatic, but conversely attenuate visceral perception.Our aim was to study visceral and somatic sensitivity in mild IBS patients and in severe IBS patients with or without FMS.

Methods: Eleven mild IBS and 19 severe IBS with and without FMS patients were studied. Somatic and visceral stimuli were applied in each patient by means of electrical stimulations at active and control sites and by means of an electronic barostat in the rectum. Thresholds for discomfort and perception cumulative scores were measured.

Results: Mild and severe IBS patients without FMS demonstrated a significantly lower somatic perception cumulative score than severe IBS patients with FMS at active site. Conversely only severe IBS patients without FMS had significantly lower visceral thresholds for discomfort than mild IBS patients and severe IBS patients with FMS.

Conclusions: The presence of co-existing FMS or greater FBDSI affects somatic and visceral perception in a graded fashion across IBS patients.

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Related in: MedlinePlus

Somatic thresholds for discomfort did not significantly differ among groups at active and control sites (p = 0.4 and 0.3, respectively). The somatic perception cumulative score was significantly different among groups at active and control sites (p = 0.006 and p = 0.03, respectively). In detail, at active site mild and severe IBS patients without FMS demonstrated a significantly lower somatic perception cumulative score than severe IBS patients with FMS, whilst at control site only mild IBS patients showed a significantly lower somatic perception cumulative score compared to severe IBS with FMS.
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Fig1: Somatic thresholds for discomfort did not significantly differ among groups at active and control sites (p = 0.4 and 0.3, respectively). The somatic perception cumulative score was significantly different among groups at active and control sites (p = 0.006 and p = 0.03, respectively). In detail, at active site mild and severe IBS patients without FMS demonstrated a significantly lower somatic perception cumulative score than severe IBS patients with FMS, whilst at control site only mild IBS patients showed a significantly lower somatic perception cumulative score compared to severe IBS with FMS.

Mentions: TENS I stimuli induced increased somatic perception in all IBS patients. Thresholds for discomfort did not significantly differ among mild IBS, severe IBS without FMS and severe IBS with FMS at active [25.4 ± 2.2 (16–34) vs 24.9 ± 2.9 (14–44) vs 19.8 ± 2.6 (13–30)] and control sites [20.8 ± 2.4 (11–36) vs 18.6 ± 2.8 (12–35) vs 14.6 ± 2.4 (8–23)] after adjusting for covariates: gender and age (ANOVA, p = 0.4 and 0.3, respectively). Gender and age did not significantly relate to the thresholds for discomfort at active and control sites. There was a lack of significant correlation between IBS severity and somatic thresholds for discomfort (R = -0.286, p = 0.2 at control and R = -0-09, p = 0.7 at active sites, respectively). The somatic perception cumulative score was calculated from 0 to 8 mA, which was used as the upper limit because one patient experienced discomfort at that level. The somatic perception cumulative score was significantly different among groups after adjusting for covariates: gender and age at active site (ANOVA, p = 0.006) and control site (ANOVA, p = 0.03). Gender and age did not significantly relate to the somatic perception cumulative score at active and control sites. At active site mild and severe IBS patients without FMS demonstrated a significantly lower somatic perception cumulative score than severe IBS patients with FMS [1.0 ± 0.4 (0–4) and 1.8 ± 0.6 (0–6) vs 9.3 ± 3.2 (2–24) respectively, m ± SE (min-max), Bonferroni test, p < 0.05], whilst at control site only mild IBS patients without FMS showed a significantly lower somatic perception cumulative score compared to severe IBS with FMS [2.6 ± 1.1(0–10) vs 8.5 ± 1.6(3–14), Bonferroni test p < 0.05] (Figure 1), whilst no significant difference was reached in comparison to severe IBS patients without FMS [3.9 ± 1.2 (0–10)].Figure 1


The severity of irritable bowel syndrome or the presence of fibromyalgia influencing the perception of visceral and somatic stimuli.

Tremolaterra F, Gallotta S, Morra Y, Lubrano E, Ciacci C, Iovino P - BMC Gastroenterol (2014)

Somatic thresholds for discomfort did not significantly differ among groups at active and control sites (p = 0.4 and 0.3, respectively). The somatic perception cumulative score was significantly different among groups at active and control sites (p = 0.006 and p = 0.03, respectively). In detail, at active site mild and severe IBS patients without FMS demonstrated a significantly lower somatic perception cumulative score than severe IBS patients with FMS, whilst at control site only mild IBS patients showed a significantly lower somatic perception cumulative score compared to severe IBS with FMS.
© Copyright Policy - open-access
Related In: Results  -  Collection

License 1 - License 2
Show All Figures
getmorefigures.php?uid=PMC4288631&req=5

Fig1: Somatic thresholds for discomfort did not significantly differ among groups at active and control sites (p = 0.4 and 0.3, respectively). The somatic perception cumulative score was significantly different among groups at active and control sites (p = 0.006 and p = 0.03, respectively). In detail, at active site mild and severe IBS patients without FMS demonstrated a significantly lower somatic perception cumulative score than severe IBS patients with FMS, whilst at control site only mild IBS patients showed a significantly lower somatic perception cumulative score compared to severe IBS with FMS.
Mentions: TENS I stimuli induced increased somatic perception in all IBS patients. Thresholds for discomfort did not significantly differ among mild IBS, severe IBS without FMS and severe IBS with FMS at active [25.4 ± 2.2 (16–34) vs 24.9 ± 2.9 (14–44) vs 19.8 ± 2.6 (13–30)] and control sites [20.8 ± 2.4 (11–36) vs 18.6 ± 2.8 (12–35) vs 14.6 ± 2.4 (8–23)] after adjusting for covariates: gender and age (ANOVA, p = 0.4 and 0.3, respectively). Gender and age did not significantly relate to the thresholds for discomfort at active and control sites. There was a lack of significant correlation between IBS severity and somatic thresholds for discomfort (R = -0.286, p = 0.2 at control and R = -0-09, p = 0.7 at active sites, respectively). The somatic perception cumulative score was calculated from 0 to 8 mA, which was used as the upper limit because one patient experienced discomfort at that level. The somatic perception cumulative score was significantly different among groups after adjusting for covariates: gender and age at active site (ANOVA, p = 0.006) and control site (ANOVA, p = 0.03). Gender and age did not significantly relate to the somatic perception cumulative score at active and control sites. At active site mild and severe IBS patients without FMS demonstrated a significantly lower somatic perception cumulative score than severe IBS patients with FMS [1.0 ± 0.4 (0–4) and 1.8 ± 0.6 (0–6) vs 9.3 ± 3.2 (2–24) respectively, m ± SE (min-max), Bonferroni test, p < 0.05], whilst at control site only mild IBS patients without FMS showed a significantly lower somatic perception cumulative score compared to severe IBS with FMS [2.6 ± 1.1(0–10) vs 8.5 ± 1.6(3–14), Bonferroni test p < 0.05] (Figure 1), whilst no significant difference was reached in comparison to severe IBS patients without FMS [3.9 ± 1.2 (0–10)].Figure 1

Bottom Line: Mild and severe IBS patients without FMS demonstrated a significantly lower somatic perception cumulative score than severe IBS patients with FMS at active site.Conversely only severe IBS patients without FMS had significantly lower visceral thresholds for discomfort than mild IBS patients and severe IBS patients with FMS.The presence of co-existing FMS or greater FBDSI affects somatic and visceral perception in a graded fashion across IBS patients.

View Article: PubMed Central - PubMed

Affiliation: Gastrointestinal Unit, Department of Medicine and Surgery, University of Salerno, Via S, Allende, 84081 Baronissi, SA, Italy. piovino@unisa.it.

ABSTRACT

Background: Fibromyalgia Syndrome (FMS) is a frequent comorbidity in Irritable Bowel Syndrome (IBS) patients with a higher functional bowel disorder severity index (FBDSI). We tested the possibility that mild to severe IBS patients without FMS would have a graduated visceral and somatic perception, and the presence of FMS would further enhance somatic, but conversely attenuate visceral perception.Our aim was to study visceral and somatic sensitivity in mild IBS patients and in severe IBS patients with or without FMS.

Methods: Eleven mild IBS and 19 severe IBS with and without FMS patients were studied. Somatic and visceral stimuli were applied in each patient by means of electrical stimulations at active and control sites and by means of an electronic barostat in the rectum. Thresholds for discomfort and perception cumulative scores were measured.

Results: Mild and severe IBS patients without FMS demonstrated a significantly lower somatic perception cumulative score than severe IBS patients with FMS at active site. Conversely only severe IBS patients without FMS had significantly lower visceral thresholds for discomfort than mild IBS patients and severe IBS patients with FMS.

Conclusions: The presence of co-existing FMS or greater FBDSI affects somatic and visceral perception in a graded fashion across IBS patients.

Show MeSH
Related in: MedlinePlus