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Association between circulating 25-hydroxyvitamin D and incident type 2 diabetes: a mendelian randomisation study.

Ye Z, Sharp SJ, Burgess S, Scott RA, Imamura F, InterAct ConsortiumLangenberg C, Wareham NJ, Forouhi NG - Lancet Diabetes Endocrinol (2014)

Bottom Line: All four SNPs were associated with 25(OH)D concentrations (p<10(-6)).The mendelian randomisation-derived estimates for glycaemic traits were not significant (p>0·25).UK Medical Research Council Epidemiology Unit and European Union Sixth Framework Programme.

View Article: PubMed Central - PubMed

Affiliation: MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Institute of Metabolic Science, Cambridge, UK.

No MeSH data available.


Related in: MedlinePlus

Mendelian randomisation and observational estimates for effect of a 1 SD reduction in 25(OH)D concentration on risk of type 2 diabetesThe mendelian randomisation estimate (odds ratio [OR] with 95% CIs) was determined by instrumental variable analysis and the observational estimate (relative risk [RR] with 95% CIs) was determined by meta-analysis of prospective observational studies. 1 SD of 25-hydroxyvitamin D (25[OH]D) concentration was 25·0 nmol/L.
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fig3: Mendelian randomisation and observational estimates for effect of a 1 SD reduction in 25(OH)D concentration on risk of type 2 diabetesThe mendelian randomisation estimate (odds ratio [OR] with 95% CIs) was determined by instrumental variable analysis and the observational estimate (relative risk [RR] with 95% CIs) was determined by meta-analysis of prospective observational studies. 1 SD of 25-hydroxyvitamin D (25[OH]D) concentration was 25·0 nmol/L.

Mentions: Mendelian randomisation analysis showed no significant associations of 25(OH)D with risk of type 2 diabetes risk. The summary OR per 1 SD lower 25(OH)D concentration was 1·01 (95% CI 0·75–1·36; p=0·94; figure 3). Similarly, the results were not significant for individual alleles or any allelic scores (appendix p 11). In the sensitivity analysis in which we combined two previously reported mendelian randomisation-based estimates,9,11 the results were unchanged: OR per 1 SD lower 25(OH)D concentration was 1·04 (95% CI 0·82–1·31) for the four SNPs combined, 1·16 (0·95–1·41) for the two SNPs related to 25(OH)D synthesis, and 0·95 (0·64–1·42) for the two SNPs related to 25(OH)D metabolism.


Association between circulating 25-hydroxyvitamin D and incident type 2 diabetes: a mendelian randomisation study.

Ye Z, Sharp SJ, Burgess S, Scott RA, Imamura F, InterAct ConsortiumLangenberg C, Wareham NJ, Forouhi NG - Lancet Diabetes Endocrinol (2014)

Mendelian randomisation and observational estimates for effect of a 1 SD reduction in 25(OH)D concentration on risk of type 2 diabetesThe mendelian randomisation estimate (odds ratio [OR] with 95% CIs) was determined by instrumental variable analysis and the observational estimate (relative risk [RR] with 95% CIs) was determined by meta-analysis of prospective observational studies. 1 SD of 25-hydroxyvitamin D (25[OH]D) concentration was 25·0 nmol/L.
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4286815&req=5

fig3: Mendelian randomisation and observational estimates for effect of a 1 SD reduction in 25(OH)D concentration on risk of type 2 diabetesThe mendelian randomisation estimate (odds ratio [OR] with 95% CIs) was determined by instrumental variable analysis and the observational estimate (relative risk [RR] with 95% CIs) was determined by meta-analysis of prospective observational studies. 1 SD of 25-hydroxyvitamin D (25[OH]D) concentration was 25·0 nmol/L.
Mentions: Mendelian randomisation analysis showed no significant associations of 25(OH)D with risk of type 2 diabetes risk. The summary OR per 1 SD lower 25(OH)D concentration was 1·01 (95% CI 0·75–1·36; p=0·94; figure 3). Similarly, the results were not significant for individual alleles or any allelic scores (appendix p 11). In the sensitivity analysis in which we combined two previously reported mendelian randomisation-based estimates,9,11 the results were unchanged: OR per 1 SD lower 25(OH)D concentration was 1·04 (95% CI 0·82–1·31) for the four SNPs combined, 1·16 (0·95–1·41) for the two SNPs related to 25(OH)D synthesis, and 0·95 (0·64–1·42) for the two SNPs related to 25(OH)D metabolism.

Bottom Line: All four SNPs were associated with 25(OH)D concentrations (p<10(-6)).The mendelian randomisation-derived estimates for glycaemic traits were not significant (p>0·25).UK Medical Research Council Epidemiology Unit and European Union Sixth Framework Programme.

View Article: PubMed Central - PubMed

Affiliation: MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Institute of Metabolic Science, Cambridge, UK.

No MeSH data available.


Related in: MedlinePlus