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Attenuation of cisplathin-induced toxic oxidative stress by propofol.

Taheri Moghadam G, Hosseini-Zijoud SM, Heidary Shayesteh T, Ghasemi H, Ranjbar A - Anesth Pain Med (2014)

Bottom Line: Antioxidant effects of propofol (2, 6-diisopropylphenol) were evaluated against cisplatin-i‎nduced oxidative stress in rat.Oxidative stress induced by cisplatin, was evident by a significant increase in LPO and decrease in TTG and TAC.Propofol recovered ‎cisplatin -induced changes in TAC, TTG and LPO in blood.

View Article: PubMed Central - PubMed

Affiliation: Student Research Committee, Hamadan University of Medical Sciences, Hamadan, Iran.

ABSTRACT

Background: Antioxidant effects of propofol (2, 6-diisopropylphenol) were evaluated against cisplatin-i‎nduced oxidative stress in rat.

Objectives: In this experimental study, 20 male rats were equally divided into 4 groups (5 rats each), and were treated by propofol (10 mg/kg/day, IP), or cisplatin (7 mg /kg/day, IP), or both.

Materials and methods: G‎roup one was control, while group 2 was given cisplatin (7 mg /kg/day, IP). Animals of the third group received only propofol (10 mg/kg/day, IP). Group 4 was given propofol with cisplatin once per day for 7 days. After treatment, blood urea nitrogen, creatinine levels, and oxidative stress m‎arkers such as total thiol groups (TTG), lipid peroxidation (LPO), and total antioxidant ‎capacity (TAC) were measured.

Results: Oxidative stress induced by cisplatin, was evident by a significant increase in LPO and decrease in TTG and TAC. Propofol recovered ‎cisplatin -induced changes in TAC, TTG and LPO in blood.

Conclusions: It is concluded that oxidative ‎damage is the mechanism of cisplatin toxicity, which can be recovered by propofol.‎

No MeSH data available.


Related in: MedlinePlus

Total Antioxidant Capacity (TAC) in Blood RatsValues are the mean ± SE 95%CI, (n = 5). aa Significantly different from control group at P ‎‎< 0.05. bb Significantly different from Cis group at P < 0.05. Pf, propofol; Cis, cisplatin; Pf + Cis, propofol +cisplatin‎)
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fig13312: Total Antioxidant Capacity (TAC) in Blood RatsValues are the mean ± SE 95%CI, (n = 5). aa Significantly different from control group at P ‎‎< 0.05. bb Significantly different from Cis group at P < 0.05. Pf, propofol; Cis, cisplatin; Pf + Cis, propofol +cisplatin‎)

Mentions: Cisplatin caused a significant decrease in TAC when compared with the control group (P = 0.001). Treatment with propofol improved TAC compared with the cisplatin group (P = 0.04). Coadministration of cisplatin with propofol significantly increased TAC level compared with the cisplatin group (P = 0.02) (Figure 5).


Attenuation of cisplathin-induced toxic oxidative stress by propofol.

Taheri Moghadam G, Hosseini-Zijoud SM, Heidary Shayesteh T, Ghasemi H, Ranjbar A - Anesth Pain Med (2014)

Total Antioxidant Capacity (TAC) in Blood RatsValues are the mean ± SE 95%CI, (n = 5). aa Significantly different from control group at P ‎‎< 0.05. bb Significantly different from Cis group at P < 0.05. Pf, propofol; Cis, cisplatin; Pf + Cis, propofol +cisplatin‎)
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4286804&req=5

fig13312: Total Antioxidant Capacity (TAC) in Blood RatsValues are the mean ± SE 95%CI, (n = 5). aa Significantly different from control group at P ‎‎< 0.05. bb Significantly different from Cis group at P < 0.05. Pf, propofol; Cis, cisplatin; Pf + Cis, propofol +cisplatin‎)
Mentions: Cisplatin caused a significant decrease in TAC when compared with the control group (P = 0.001). Treatment with propofol improved TAC compared with the cisplatin group (P = 0.04). Coadministration of cisplatin with propofol significantly increased TAC level compared with the cisplatin group (P = 0.02) (Figure 5).

Bottom Line: Antioxidant effects of propofol (2, 6-diisopropylphenol) were evaluated against cisplatin-i‎nduced oxidative stress in rat.Oxidative stress induced by cisplatin, was evident by a significant increase in LPO and decrease in TTG and TAC.Propofol recovered ‎cisplatin -induced changes in TAC, TTG and LPO in blood.

View Article: PubMed Central - PubMed

Affiliation: Student Research Committee, Hamadan University of Medical Sciences, Hamadan, Iran.

ABSTRACT

Background: Antioxidant effects of propofol (2, 6-diisopropylphenol) were evaluated against cisplatin-i‎nduced oxidative stress in rat.

Objectives: In this experimental study, 20 male rats were equally divided into 4 groups (5 rats each), and were treated by propofol (10 mg/kg/day, IP), or cisplatin (7 mg /kg/day, IP), or both.

Materials and methods: G‎roup one was control, while group 2 was given cisplatin (7 mg /kg/day, IP). Animals of the third group received only propofol (10 mg/kg/day, IP). Group 4 was given propofol with cisplatin once per day for 7 days. After treatment, blood urea nitrogen, creatinine levels, and oxidative stress m‎arkers such as total thiol groups (TTG), lipid peroxidation (LPO), and total antioxidant ‎capacity (TAC) were measured.

Results: Oxidative stress induced by cisplatin, was evident by a significant increase in LPO and decrease in TTG and TAC. Propofol recovered ‎cisplatin -induced changes in TAC, TTG and LPO in blood.

Conclusions: It is concluded that oxidative ‎damage is the mechanism of cisplatin toxicity, which can be recovered by propofol.‎

No MeSH data available.


Related in: MedlinePlus