Limits...
A Case of Organizing Pneumonia Associated with FOLFIRI Chemotherapy.

Lee YJ, Kim JH, Kim SW, Kang WC, Kim SJ, Kim JH, Kim SJ - Tuberc Respir Dis (Seoul) (2014)

Bottom Line: Pulmonary toxicity is very rare in adverse effects of irinotecan.No case of organizing pneumonia (also known as bronchiolitis obliterans organizing pneumonia) associated with FOLFIRI chemotherapy has been reported.After surgical lung biopsy, the patient was diagnosed with FOLFIRI chemotherapy-induced organizing pneumonia which was successfully treated with steroid therapy.

View Article: PubMed Central - PubMed

Affiliation: Department of Internal Medicine, Konkuk University Hospital, Konkuk University School of Medicine, Seoul, Korea.

ABSTRACT
The combination chemotherapy of irinotecan with 5-fluorouracil and leucovorin (FOLFIRI regimen) was recently proven to be beneficial in patients with advanced colorectal cancer. Pulmonary toxicity is very rare in adverse effects of irinotecan. No case of organizing pneumonia (also known as bronchiolitis obliterans organizing pneumonia) associated with FOLFIRI chemotherapy has been reported. We experienced a case of a 62-year-old man who presented persistent dry cough and progressive dyspnea after receiving chemotherapy with FOLFIRI regimen. After surgical lung biopsy, the patient was diagnosed with FOLFIRI chemotherapy-induced organizing pneumonia which was successfully treated with steroid therapy.

No MeSH data available.


Related in: MedlinePlus

Chest X-ray (A) and chest high resolution computed tomography (B) on admission showing multifocal patchy consolidation and ground glass opacities on both lungs, mainly on the right lung.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
getmorefigures.php?uid=PMC4286784&req=5

Figure 1: Chest X-ray (A) and chest high resolution computed tomography (B) on admission showing multifocal patchy consolidation and ground glass opacities on both lungs, mainly on the right lung.

Mentions: His vital signs on admission were followings: blood pressure of 147/96 mm Hg, pulse rate of 99/min, respiratory rate of 22/min, body temperate of 38.4℃, and oxygen saturation of 95%. Auscultation of lungs revealed coarse breathing sound with crackle on right upper and lower lung fields. Laboratory findings were as follows: white blood cell 16,750/mm3 (neutrophil 89%), hemoglobin 9.8 g/dL, platelet 252,000/mm3, C-reactive protein 12.96 mg/L, and erythrocyte sedimentation rate 61 mm/hr. Chest X-ray on admission showed multiple patchy consolidation on right upper, right lower and left lower lung fields. Chest high resolution computed tomography (HRCT) revealed multifocal patchy ground glass opacities and consolidation on both lungs, mainly right lung (Figure 1).


A Case of Organizing Pneumonia Associated with FOLFIRI Chemotherapy.

Lee YJ, Kim JH, Kim SW, Kang WC, Kim SJ, Kim JH, Kim SJ - Tuberc Respir Dis (Seoul) (2014)

Chest X-ray (A) and chest high resolution computed tomography (B) on admission showing multifocal patchy consolidation and ground glass opacities on both lungs, mainly on the right lung.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4286784&req=5

Figure 1: Chest X-ray (A) and chest high resolution computed tomography (B) on admission showing multifocal patchy consolidation and ground glass opacities on both lungs, mainly on the right lung.
Mentions: His vital signs on admission were followings: blood pressure of 147/96 mm Hg, pulse rate of 99/min, respiratory rate of 22/min, body temperate of 38.4℃, and oxygen saturation of 95%. Auscultation of lungs revealed coarse breathing sound with crackle on right upper and lower lung fields. Laboratory findings were as follows: white blood cell 16,750/mm3 (neutrophil 89%), hemoglobin 9.8 g/dL, platelet 252,000/mm3, C-reactive protein 12.96 mg/L, and erythrocyte sedimentation rate 61 mm/hr. Chest X-ray on admission showed multiple patchy consolidation on right upper, right lower and left lower lung fields. Chest high resolution computed tomography (HRCT) revealed multifocal patchy ground glass opacities and consolidation on both lungs, mainly right lung (Figure 1).

Bottom Line: Pulmonary toxicity is very rare in adverse effects of irinotecan.No case of organizing pneumonia (also known as bronchiolitis obliterans organizing pneumonia) associated with FOLFIRI chemotherapy has been reported.After surgical lung biopsy, the patient was diagnosed with FOLFIRI chemotherapy-induced organizing pneumonia which was successfully treated with steroid therapy.

View Article: PubMed Central - PubMed

Affiliation: Department of Internal Medicine, Konkuk University Hospital, Konkuk University School of Medicine, Seoul, Korea.

ABSTRACT
The combination chemotherapy of irinotecan with 5-fluorouracil and leucovorin (FOLFIRI regimen) was recently proven to be beneficial in patients with advanced colorectal cancer. Pulmonary toxicity is very rare in adverse effects of irinotecan. No case of organizing pneumonia (also known as bronchiolitis obliterans organizing pneumonia) associated with FOLFIRI chemotherapy has been reported. We experienced a case of a 62-year-old man who presented persistent dry cough and progressive dyspnea after receiving chemotherapy with FOLFIRI regimen. After surgical lung biopsy, the patient was diagnosed with FOLFIRI chemotherapy-induced organizing pneumonia which was successfully treated with steroid therapy.

No MeSH data available.


Related in: MedlinePlus