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Bilateral Ovarian Metastases from ALK Rearranged Non-Small Cell Lung Cancer.

Lee KA, Lee JS, Min JK, Kim HJ, Kim WS, Lee KY - Tuberc Respir Dis (Seoul) (2014)

Bottom Line: Metastasis from lung cancer to the ovary has rarely been known.We report a case of a 54-year-old woman with bilateral ovarian metastases from ALK rearranged NSCLC.Histopathological examination of the ovary tumor showed characteristic adenocarcinoma patterns of the lung and ALK rearrangement.

View Article: PubMed Central - PubMed

Affiliation: Department of Internal Medicine, Konkuk University School of Medicine, Seoul, Korea.

ABSTRACT
Anaplastic lymphoma kinase (ALK) rearrangement, is a kind of driver mutation, accounts for 3%-5% of non-small cell lung cancer (NSCLC). NSCLC patients harboring ALK fusion genes have distinct clinical features and good response to ALK inhibitors. Metastasis from lung cancer to the ovary has rarely been known. We report a case of a 54-year-old woman with bilateral ovarian metastases from ALK rearranged NSCLC. She underwent bilateral salpingo-oophorectomy for ovary masses, which were progressed after cytotoxic chemotherapy although primary lung mass was decreased. Histopathological examination of the ovary tumor showed characteristic adenocarcinoma patterns of the lung and ALK rearrangement.

No MeSH data available.


Related in: MedlinePlus

Bilateral ovarian metastases of lung cancer at the initial positron emission tomography-computed tomography scan showing hypermetabolic activity in both ovaries (maximum standardized uptake value: right 15.7, left 13.4).
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Figure 2: Bilateral ovarian metastases of lung cancer at the initial positron emission tomography-computed tomography scan showing hypermetabolic activity in both ovaries (maximum standardized uptake value: right 15.7, left 13.4).

Mentions: A 54-year-old woman with a 2.5 pack-year smoking history presented with cough and dyspnea. Computed tomography (CT) scan showed a 5.4- and 3.3-cm sized left lower lobe masses with left hilar and subcarinal lymphadenopathies (Figure 1). Positron emission tomography-computed tomography (PET-CT) showed increased fluorodeoxyglucose uptake in two left lower lobe masses and bilateral ovaries (Figure 2). Brain magnetic resonance imaging (MRI) revealed disseminated brain metastasis. CT-guided percutaneous transthoracic needle biopsy of the lung mass confirmed adenocarcinoma and the tumor showed marked ALK protein expression by immunohistochemistry (IHC). Fluorescent in situ hybridization (FISH) analysis for ALK translocation revealed also positive. However, an analysis of biopsy specimen showed no evidence of a preexisting mutation in epidermal growth factor receptor (EGFR) and Kirsten rat sarcoma viral oncogene (KRAS).


Bilateral Ovarian Metastases from ALK Rearranged Non-Small Cell Lung Cancer.

Lee KA, Lee JS, Min JK, Kim HJ, Kim WS, Lee KY - Tuberc Respir Dis (Seoul) (2014)

Bilateral ovarian metastases of lung cancer at the initial positron emission tomography-computed tomography scan showing hypermetabolic activity in both ovaries (maximum standardized uptake value: right 15.7, left 13.4).
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4286783&req=5

Figure 2: Bilateral ovarian metastases of lung cancer at the initial positron emission tomography-computed tomography scan showing hypermetabolic activity in both ovaries (maximum standardized uptake value: right 15.7, left 13.4).
Mentions: A 54-year-old woman with a 2.5 pack-year smoking history presented with cough and dyspnea. Computed tomography (CT) scan showed a 5.4- and 3.3-cm sized left lower lobe masses with left hilar and subcarinal lymphadenopathies (Figure 1). Positron emission tomography-computed tomography (PET-CT) showed increased fluorodeoxyglucose uptake in two left lower lobe masses and bilateral ovaries (Figure 2). Brain magnetic resonance imaging (MRI) revealed disseminated brain metastasis. CT-guided percutaneous transthoracic needle biopsy of the lung mass confirmed adenocarcinoma and the tumor showed marked ALK protein expression by immunohistochemistry (IHC). Fluorescent in situ hybridization (FISH) analysis for ALK translocation revealed also positive. However, an analysis of biopsy specimen showed no evidence of a preexisting mutation in epidermal growth factor receptor (EGFR) and Kirsten rat sarcoma viral oncogene (KRAS).

Bottom Line: Metastasis from lung cancer to the ovary has rarely been known.We report a case of a 54-year-old woman with bilateral ovarian metastases from ALK rearranged NSCLC.Histopathological examination of the ovary tumor showed characteristic adenocarcinoma patterns of the lung and ALK rearrangement.

View Article: PubMed Central - PubMed

Affiliation: Department of Internal Medicine, Konkuk University School of Medicine, Seoul, Korea.

ABSTRACT
Anaplastic lymphoma kinase (ALK) rearrangement, is a kind of driver mutation, accounts for 3%-5% of non-small cell lung cancer (NSCLC). NSCLC patients harboring ALK fusion genes have distinct clinical features and good response to ALK inhibitors. Metastasis from lung cancer to the ovary has rarely been known. We report a case of a 54-year-old woman with bilateral ovarian metastases from ALK rearranged NSCLC. She underwent bilateral salpingo-oophorectomy for ovary masses, which were progressed after cytotoxic chemotherapy although primary lung mass was decreased. Histopathological examination of the ovary tumor showed characteristic adenocarcinoma patterns of the lung and ALK rearrangement.

No MeSH data available.


Related in: MedlinePlus