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Enhanced multiple vibrational resonances by Na+ and K+ dynamics in a neuron model.

Wu XX, Yao C, Shuai J - Sci Rep (2015)

Bottom Line: The vibrational resonance effect is investigated in a neuron model in which the intra- and extra-cellular potassium and sodium concentrations are allowed to evolve temporally, depending on ion currents, Na(+)-K(+) pumps, glial buffering, and ion diffusion.Our results reveal that, compared to the vibrational resonances in the model with constant ion concentrations, the significantly enhanced vibrational multi-resonances can be observed for the single neuron system where the potassium and sodium ion concentrations vary temporally.Thus, in contradiction to a popular view that ion concentrations dynamics play little role in signal detection, we indicate that the neuron's response to an external subthreshold signal can be largely improved by sodium and potassium dynamics.

View Article: PubMed Central - PubMed

Affiliation: Department of Physics, Xiamen University, Xiamen 361005, China.

ABSTRACT
Some neuronal receptors perceive external input in the form of hybrid periodic signals. The signal detection may be based on the mechanism of vibrational resonance, in which a system's response to the low frequency signal can become optimal by an appropriate choice of the vibration amplitude of HFS. The vibrational resonance effect is investigated in a neuron model in which the intra- and extra-cellular potassium and sodium concentrations are allowed to evolve temporally, depending on ion currents, Na(+)-K(+) pumps, glial buffering, and ion diffusion. Our results reveal that, compared to the vibrational resonances in the model with constant ion concentrations, the significantly enhanced vibrational multi-resonances can be observed for the single neuron system where the potassium and sodium ion concentrations vary temporally. Thus, in contradiction to a popular view that ion concentrations dynamics play little role in signal detection, we indicate that the neuron's response to an external subthreshold signal can be largely improved by sodium and potassium dynamics.

No MeSH data available.


Related in: MedlinePlus

Dependence of response Q as a function of B for different HFS frequencies for the reduced model (a) and the full model (b).In each panel, the differently coloured lines correspond to varying values of the intensity of LFS A. For the LFS: A = 0.1–1 μA/cm2 and ω = 0.002/ms; and for the HFS: B = 0–30 μA/cm2 and ω′ = 100.65,0.9,1.4 ω.
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f5: Dependence of response Q as a function of B for different HFS frequencies for the reduced model (a) and the full model (b).In each panel, the differently coloured lines correspond to varying values of the intensity of LFS A. For the LFS: A = 0.1–1 μA/cm2 and ω = 0.002/ms; and for the HFS: B = 0–30 μA/cm2 and ω′ = 100.65,0.9,1.4 ω.

Mentions: In addition, we investigate the multiple VRs responding to varying LFS amplitudes. Each panel in Fig. 5 depicts the dependence of factor Q on the HFS amplitude for several LFS amplitudes with differently colored lines. Three particular HFS frequencies have been chosen for the two models. The phenomenon of multiple VRs is observed for various LFS amplitudes. We notice some effects of the variation in the LFS amplitude on the multiple VRs.


Enhanced multiple vibrational resonances by Na+ and K+ dynamics in a neuron model.

Wu XX, Yao C, Shuai J - Sci Rep (2015)

Dependence of response Q as a function of B for different HFS frequencies for the reduced model (a) and the full model (b).In each panel, the differently coloured lines correspond to varying values of the intensity of LFS A. For the LFS: A = 0.1–1 μA/cm2 and ω = 0.002/ms; and for the HFS: B = 0–30 μA/cm2 and ω′ = 100.65,0.9,1.4 ω.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4286765&req=5

f5: Dependence of response Q as a function of B for different HFS frequencies for the reduced model (a) and the full model (b).In each panel, the differently coloured lines correspond to varying values of the intensity of LFS A. For the LFS: A = 0.1–1 μA/cm2 and ω = 0.002/ms; and for the HFS: B = 0–30 μA/cm2 and ω′ = 100.65,0.9,1.4 ω.
Mentions: In addition, we investigate the multiple VRs responding to varying LFS amplitudes. Each panel in Fig. 5 depicts the dependence of factor Q on the HFS amplitude for several LFS amplitudes with differently colored lines. Three particular HFS frequencies have been chosen for the two models. The phenomenon of multiple VRs is observed for various LFS amplitudes. We notice some effects of the variation in the LFS amplitude on the multiple VRs.

Bottom Line: The vibrational resonance effect is investigated in a neuron model in which the intra- and extra-cellular potassium and sodium concentrations are allowed to evolve temporally, depending on ion currents, Na(+)-K(+) pumps, glial buffering, and ion diffusion.Our results reveal that, compared to the vibrational resonances in the model with constant ion concentrations, the significantly enhanced vibrational multi-resonances can be observed for the single neuron system where the potassium and sodium ion concentrations vary temporally.Thus, in contradiction to a popular view that ion concentrations dynamics play little role in signal detection, we indicate that the neuron's response to an external subthreshold signal can be largely improved by sodium and potassium dynamics.

View Article: PubMed Central - PubMed

Affiliation: Department of Physics, Xiamen University, Xiamen 361005, China.

ABSTRACT
Some neuronal receptors perceive external input in the form of hybrid periodic signals. The signal detection may be based on the mechanism of vibrational resonance, in which a system's response to the low frequency signal can become optimal by an appropriate choice of the vibration amplitude of HFS. The vibrational resonance effect is investigated in a neuron model in which the intra- and extra-cellular potassium and sodium concentrations are allowed to evolve temporally, depending on ion currents, Na(+)-K(+) pumps, glial buffering, and ion diffusion. Our results reveal that, compared to the vibrational resonances in the model with constant ion concentrations, the significantly enhanced vibrational multi-resonances can be observed for the single neuron system where the potassium and sodium ion concentrations vary temporally. Thus, in contradiction to a popular view that ion concentrations dynamics play little role in signal detection, we indicate that the neuron's response to an external subthreshold signal can be largely improved by sodium and potassium dynamics.

No MeSH data available.


Related in: MedlinePlus