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Enhanced multiple vibrational resonances by Na+ and K+ dynamics in a neuron model.

Wu XX, Yao C, Shuai J - Sci Rep (2015)

Bottom Line: The vibrational resonance effect is investigated in a neuron model in which the intra- and extra-cellular potassium and sodium concentrations are allowed to evolve temporally, depending on ion currents, Na(+)-K(+) pumps, glial buffering, and ion diffusion.Our results reveal that, compared to the vibrational resonances in the model with constant ion concentrations, the significantly enhanced vibrational multi-resonances can be observed for the single neuron system where the potassium and sodium ion concentrations vary temporally.Thus, in contradiction to a popular view that ion concentrations dynamics play little role in signal detection, we indicate that the neuron's response to an external subthreshold signal can be largely improved by sodium and potassium dynamics.

View Article: PubMed Central - PubMed

Affiliation: Department of Physics, Xiamen University, Xiamen 361005, China.

ABSTRACT
Some neuronal receptors perceive external input in the form of hybrid periodic signals. The signal detection may be based on the mechanism of vibrational resonance, in which a system's response to the low frequency signal can become optimal by an appropriate choice of the vibration amplitude of HFS. The vibrational resonance effect is investigated in a neuron model in which the intra- and extra-cellular potassium and sodium concentrations are allowed to evolve temporally, depending on ion currents, Na(+)-K(+) pumps, glial buffering, and ion diffusion. Our results reveal that, compared to the vibrational resonances in the model with constant ion concentrations, the significantly enhanced vibrational multi-resonances can be observed for the single neuron system where the potassium and sodium ion concentrations vary temporally. Thus, in contradiction to a popular view that ion concentrations dynamics play little role in signal detection, we indicate that the neuron's response to an external subthreshold signal can be largely improved by sodium and potassium dynamics.

No MeSH data available.


Contour plots of the response Q vs B and log10N for the reduced model (a) and the full model (b).The colors of black, cyan, and red correspond to increasing coherence levels. The role of ion concentrations dynamics in the production of multiple VR is better revealed by comparing these two figures. For the LFS: A = 1 μA/cm2 and ω = 0.002/ms; and for the HFS: B = 0–30 μA/cm2 and ω′ = 100–1.8ω.
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f4: Contour plots of the response Q vs B and log10N for the reduced model (a) and the full model (b).The colors of black, cyan, and red correspond to increasing coherence levels. The role of ion concentrations dynamics in the production of multiple VR is better revealed by comparing these two figures. For the LFS: A = 1 μA/cm2 and ω = 0.002/ms; and for the HFS: B = 0–30 μA/cm2 and ω′ = 100–1.8ω.

Mentions: To get a global view, the dependences of VR factor Q on the amplitude B of HFS and the frequency ratio log10N are shown for both the reduced model (Fig. 4a) and the full model (Fig. 4b). The colors of black, cyan, and red correspond to increasing input-output coherence levels. The cyan and red areas represent the occurrence of VR.


Enhanced multiple vibrational resonances by Na+ and K+ dynamics in a neuron model.

Wu XX, Yao C, Shuai J - Sci Rep (2015)

Contour plots of the response Q vs B and log10N for the reduced model (a) and the full model (b).The colors of black, cyan, and red correspond to increasing coherence levels. The role of ion concentrations dynamics in the production of multiple VR is better revealed by comparing these two figures. For the LFS: A = 1 μA/cm2 and ω = 0.002/ms; and for the HFS: B = 0–30 μA/cm2 and ω′ = 100–1.8ω.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4286765&req=5

f4: Contour plots of the response Q vs B and log10N for the reduced model (a) and the full model (b).The colors of black, cyan, and red correspond to increasing coherence levels. The role of ion concentrations dynamics in the production of multiple VR is better revealed by comparing these two figures. For the LFS: A = 1 μA/cm2 and ω = 0.002/ms; and for the HFS: B = 0–30 μA/cm2 and ω′ = 100–1.8ω.
Mentions: To get a global view, the dependences of VR factor Q on the amplitude B of HFS and the frequency ratio log10N are shown for both the reduced model (Fig. 4a) and the full model (Fig. 4b). The colors of black, cyan, and red correspond to increasing input-output coherence levels. The cyan and red areas represent the occurrence of VR.

Bottom Line: The vibrational resonance effect is investigated in a neuron model in which the intra- and extra-cellular potassium and sodium concentrations are allowed to evolve temporally, depending on ion currents, Na(+)-K(+) pumps, glial buffering, and ion diffusion.Our results reveal that, compared to the vibrational resonances in the model with constant ion concentrations, the significantly enhanced vibrational multi-resonances can be observed for the single neuron system where the potassium and sodium ion concentrations vary temporally.Thus, in contradiction to a popular view that ion concentrations dynamics play little role in signal detection, we indicate that the neuron's response to an external subthreshold signal can be largely improved by sodium and potassium dynamics.

View Article: PubMed Central - PubMed

Affiliation: Department of Physics, Xiamen University, Xiamen 361005, China.

ABSTRACT
Some neuronal receptors perceive external input in the form of hybrid periodic signals. The signal detection may be based on the mechanism of vibrational resonance, in which a system's response to the low frequency signal can become optimal by an appropriate choice of the vibration amplitude of HFS. The vibrational resonance effect is investigated in a neuron model in which the intra- and extra-cellular potassium and sodium concentrations are allowed to evolve temporally, depending on ion currents, Na(+)-K(+) pumps, glial buffering, and ion diffusion. Our results reveal that, compared to the vibrational resonances in the model with constant ion concentrations, the significantly enhanced vibrational multi-resonances can be observed for the single neuron system where the potassium and sodium ion concentrations vary temporally. Thus, in contradiction to a popular view that ion concentrations dynamics play little role in signal detection, we indicate that the neuron's response to an external subthreshold signal can be largely improved by sodium and potassium dynamics.

No MeSH data available.