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Protective Effect of Liriodendrin Isolated from Kalopanax pictus against Gastric Injury.

Sohn YA, Hwang SA, Lee SY, Hwang IY, Kim SW, Kim SY, Moon A, Lee YS, Kim YH, Kang KJ, Jeong CS - Biomol Ther (Seoul) (2015)

Bottom Line: It was also exhibited acid-neutralizing capacity (10.3%) and H(+)/K(+)-ATPase inhibition of 42.6% (500 μM).Furthermore liriodendrin inhibited colonization of H. pylori effectively.From these results, we suggest that liriodendrin could be utilized for the treatment and/or protection of gastritis and gastric ulcer.

View Article: PubMed Central - PubMed

Affiliation: College of Pharmacy, Duksung Women's University, Seoul 132-714.

ABSTRACT
In this study, we investigated the inhibitory activities on gastritis and gastric ulcer using liriodendrin which is a constituent isolated from Kalopanax pictus. To elucidate its abilities to prevent gastric injury, we measured the quantity of prostaglandin E2 (PGE2) as the protective factor, and we assessed inhibition of activities related to excessive gastric acid be notorious for aggressive factor and inhibition of Helicobacter pylori (H. pylori) colonization known as a cause of chronic gastritis, gastric ulcer, and gastric cancer. Liriodendrin exhibited higher PGE2 level than rebamipide used as a positive control group at the dose of 500 μM. It was also exhibited acid-neutralizing capacity (10.3%) and H(+)/K(+)-ATPase inhibition of 42.6% (500 μM). In pylorus-ligated rats, liriodendrin showed lower volume of gastric juice (4.38 ± 2.14 ml), slightly higher pH (1.53 ± 0.41), and smaller total acid output (0.47 ± 0.3 mEq/4 hrs) than the control group. Furthermore liriodendrin inhibited colonization of H. pylori effectively. In vivo test, liriodendrin significantly inhibited both of HCl/EtOH-induced gastritis (46.9 %) and indomethacin-induced gastric ulcer (46.1%). From these results, we suggest that liriodendrin could be utilized for the treatment and/or protection of gastritis and gastric ulcer.

No MeSH data available.


Related in: MedlinePlus

The effect of liriodendrin on indomethacin-induced gastric ulcer in rats. A: Control group; B: Liriodendrine treatment group (100 mg/kg), Typical macro view of stomachs: Indomethacin-induced black-red hemorrhagic lesions were pointed by the arrows in the gastric mucosa and pretreatment with liriodendrin markedly reduced the number and severity of these lesions.
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f7-bt-23-53: The effect of liriodendrin on indomethacin-induced gastric ulcer in rats. A: Control group; B: Liriodendrine treatment group (100 mg/kg), Typical macro view of stomachs: Indomethacin-induced black-red hemorrhagic lesions were pointed by the arrows in the gastric mucosa and pretreatment with liriodendrin markedly reduced the number and severity of these lesions.

Mentions: Subcutaneous injection of indomethacin induces mucosal blood flow decrease characterized by oxidative damage and gastric lesion by decrease by inhibiting PG secretion. According to study of Kunikata et al. (2001), subcutaneous injection of indomethacin significantly induced ulcerative lesions therefore we experimented that method. After administration of indomethacin, ulcerative lesions of the control group were observed at 29.7 ± 3.06 mm2. Liriodendrin (100 mg/kg) treated group were observed ulcerative lesions of 16.0 ± 2.55 mm2 and showed the inhibitory effect of 46.1%. Compared with the administration of cimetidine (14.04 ± 5.7 mm2), significant effect could be confirmed (Table 5, Fig. 7). Indomethacin, NSAIDs can induce gastric ulcer and severe gastric mucosal lesions. Liriodendrin exhibited indomethacin-induced gastric ulcer inhibitory activity therefore it showed liriodenrin has antigastric ulcer effects.


Protective Effect of Liriodendrin Isolated from Kalopanax pictus against Gastric Injury.

Sohn YA, Hwang SA, Lee SY, Hwang IY, Kim SW, Kim SY, Moon A, Lee YS, Kim YH, Kang KJ, Jeong CS - Biomol Ther (Seoul) (2015)

The effect of liriodendrin on indomethacin-induced gastric ulcer in rats. A: Control group; B: Liriodendrine treatment group (100 mg/kg), Typical macro view of stomachs: Indomethacin-induced black-red hemorrhagic lesions were pointed by the arrows in the gastric mucosa and pretreatment with liriodendrin markedly reduced the number and severity of these lesions.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4286750&req=5

f7-bt-23-53: The effect of liriodendrin on indomethacin-induced gastric ulcer in rats. A: Control group; B: Liriodendrine treatment group (100 mg/kg), Typical macro view of stomachs: Indomethacin-induced black-red hemorrhagic lesions were pointed by the arrows in the gastric mucosa and pretreatment with liriodendrin markedly reduced the number and severity of these lesions.
Mentions: Subcutaneous injection of indomethacin induces mucosal blood flow decrease characterized by oxidative damage and gastric lesion by decrease by inhibiting PG secretion. According to study of Kunikata et al. (2001), subcutaneous injection of indomethacin significantly induced ulcerative lesions therefore we experimented that method. After administration of indomethacin, ulcerative lesions of the control group were observed at 29.7 ± 3.06 mm2. Liriodendrin (100 mg/kg) treated group were observed ulcerative lesions of 16.0 ± 2.55 mm2 and showed the inhibitory effect of 46.1%. Compared with the administration of cimetidine (14.04 ± 5.7 mm2), significant effect could be confirmed (Table 5, Fig. 7). Indomethacin, NSAIDs can induce gastric ulcer and severe gastric mucosal lesions. Liriodendrin exhibited indomethacin-induced gastric ulcer inhibitory activity therefore it showed liriodenrin has antigastric ulcer effects.

Bottom Line: It was also exhibited acid-neutralizing capacity (10.3%) and H(+)/K(+)-ATPase inhibition of 42.6% (500 μM).Furthermore liriodendrin inhibited colonization of H. pylori effectively.From these results, we suggest that liriodendrin could be utilized for the treatment and/or protection of gastritis and gastric ulcer.

View Article: PubMed Central - PubMed

Affiliation: College of Pharmacy, Duksung Women's University, Seoul 132-714.

ABSTRACT
In this study, we investigated the inhibitory activities on gastritis and gastric ulcer using liriodendrin which is a constituent isolated from Kalopanax pictus. To elucidate its abilities to prevent gastric injury, we measured the quantity of prostaglandin E2 (PGE2) as the protective factor, and we assessed inhibition of activities related to excessive gastric acid be notorious for aggressive factor and inhibition of Helicobacter pylori (H. pylori) colonization known as a cause of chronic gastritis, gastric ulcer, and gastric cancer. Liriodendrin exhibited higher PGE2 level than rebamipide used as a positive control group at the dose of 500 μM. It was also exhibited acid-neutralizing capacity (10.3%) and H(+)/K(+)-ATPase inhibition of 42.6% (500 μM). In pylorus-ligated rats, liriodendrin showed lower volume of gastric juice (4.38 ± 2.14 ml), slightly higher pH (1.53 ± 0.41), and smaller total acid output (0.47 ± 0.3 mEq/4 hrs) than the control group. Furthermore liriodendrin inhibited colonization of H. pylori effectively. In vivo test, liriodendrin significantly inhibited both of HCl/EtOH-induced gastritis (46.9 %) and indomethacin-induced gastric ulcer (46.1%). From these results, we suggest that liriodendrin could be utilized for the treatment and/or protection of gastritis and gastric ulcer.

No MeSH data available.


Related in: MedlinePlus