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Dose- and time-dependent effects of triamcinolone acetonide on human rotator cuff-derived cells.

Harada Y, Kokubu T, Mifune Y, Inui A, Sakata R, Muto T, Takase F, Kurosaka M - Bone Joint Res (2014)

Bottom Line: In the low TA group, apoptosis and viability returned to normal at 21 days, however, in the high TA group, the cell morphology, apoptosis ratio, caspase-3, 7, 8, and 9 and viability did not return by day 21.A 0.1 mg/mL dose of TA temporarily decreased cell viability and increased cell apoptosis, which was recovered at 21 days, however, 1 mg/mL of TA caused irreversible damage to cell morphology and viability.Cite this article: Bone Joint Res 2014;3:328-34.

View Article: PubMed Central - PubMed

Affiliation: Kobe University Graduate School of Medicine, Department of Orthopedic Surgery, 7-5-2 Kusunoki-cho, Chuo-ku, Kobe, 6500017, Japan.

No MeSH data available.


Related in: MedlinePlus

Graphs showing that real-time PCRrevealed that the mRNA expressions of caspase-3, 7, 8, and 9 inthe TA-treated group were significantly increased at day 7 comparedwith a) those in the control group (p < 0.05;). All mRNA expressionsof caspase were significantly reduced in b) the low TA group atday 21 (p < 0.05;). There was no decrease in high TA group at day21.
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Related In: Results  -  Collection


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f5: Graphs showing that real-time PCRrevealed that the mRNA expressions of caspase-3, 7, 8, and 9 inthe TA-treated group were significantly increased at day 7 comparedwith a) those in the control group (p < 0.05;). All mRNA expressionsof caspase were significantly reduced in b) the low TA group atday 21 (p < 0.05;). There was no decrease in high TA group at day21.


Dose- and time-dependent effects of triamcinolone acetonide on human rotator cuff-derived cells.

Harada Y, Kokubu T, Mifune Y, Inui A, Sakata R, Muto T, Takase F, Kurosaka M - Bone Joint Res (2014)

Graphs showing that real-time PCRrevealed that the mRNA expressions of caspase-3, 7, 8, and 9 inthe TA-treated group were significantly increased at day 7 comparedwith a) those in the control group (p < 0.05;). All mRNA expressionsof caspase were significantly reduced in b) the low TA group atday 21 (p < 0.05;). There was no decrease in high TA group at day21.
© Copyright Policy - open-access
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC4286699&req=5

f5: Graphs showing that real-time PCRrevealed that the mRNA expressions of caspase-3, 7, 8, and 9 inthe TA-treated group were significantly increased at day 7 comparedwith a) those in the control group (p < 0.05;). All mRNA expressionsof caspase were significantly reduced in b) the low TA group atday 21 (p < 0.05;). There was no decrease in high TA group at day21.
Bottom Line: In the low TA group, apoptosis and viability returned to normal at 21 days, however, in the high TA group, the cell morphology, apoptosis ratio, caspase-3, 7, 8, and 9 and viability did not return by day 21.A 0.1 mg/mL dose of TA temporarily decreased cell viability and increased cell apoptosis, which was recovered at 21 days, however, 1 mg/mL of TA caused irreversible damage to cell morphology and viability.Cite this article: Bone Joint Res 2014;3:328-34.

View Article: PubMed Central - PubMed

Affiliation: Kobe University Graduate School of Medicine, Department of Orthopedic Surgery, 7-5-2 Kusunoki-cho, Chuo-ku, Kobe, 6500017, Japan.

No MeSH data available.


Related in: MedlinePlus