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Histological investigation of the effect of soybean (Glycine max) extracts on the collagen layer and estrogen receptors in the skin of female rats.

Uyar B, Sivrikoz ON, Ozdemir U, Dasbasi T, Sacar H - Clinics (Sao Paulo) (2014)

Bottom Line: The groups comprised carboxymethyl cellulose-free control, carboxymethyl cellulose-plus control, 100-mg/kg n-hexane extract, 200-mg/kg n-hexane extract, 100-mg/kg ethyl acetate extract, 200-mg/kg ethyl acetate extract, 100-mg/kg ethanol extract and 200-mg/kg ethanol extract groups.Regarding the thickness of the collagen layer, only the 200-mg/kg ethyl acetate extract-treated group showed a significant increase compared with the control groups (p<0.05).Our data suggest that oral intake of three different total soybean extracts might have positive estrogenic effects on the skin and that only a high-dose ethyl acetate extract can increase the expression of collagen, which may prove to be beneficial for postmenopausal facial skin.

View Article: PubMed Central - PubMed

Affiliation: Department of Dermatology, Faculty of Medicine, Sifa University, Izmir, Turkey.

ABSTRACT

Objectives: The purpose of this study was to analyze the effects of soybean extracts obtained using different extraction methods on the skin of female rats.

Method: A total of 64 female Sprague-Dawley rats were divided into 8 equal groups. Various extracts were administered to the female rats by oral gavage for one month. The groups comprised carboxymethyl cellulose-free control, carboxymethyl cellulose-plus control, 100-mg/kg n-hexane extract, 200-mg/kg n-hexane extract, 100-mg/kg ethyl acetate extract, 200-mg/kg ethyl acetate extract, 100-mg/kg ethanol extract and 200-mg/kg ethanol extract groups. The thickness of the collagen layer and the number of estrogen receptor-positive cells were evaluated.

Results: All the extract-treated groups showed a statistically significant decrease in the number of estrogen receptor-positive cells compared with the control groups. Regarding the thickness of the collagen layer, only the 200-mg/kg ethyl acetate extract-treated group showed a significant increase compared with the control groups (p<0.05).

Conclusions: Our data suggest that oral intake of three different total soybean extracts might have positive estrogenic effects on the skin and that only a high-dose ethyl acetate extract can increase the expression of collagen, which may prove to be beneficial for postmenopausal facial skin.

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Related in: MedlinePlus

The collagen layer thicknesses are presented in a box plot.
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f1-cln_69p854: The collagen layer thicknesses are presented in a box plot.

Mentions: The mean values of collagen layer thickness and number of estrogen receptor-positive cells in the different soybean extract-treated groups are shown in Table 1. The collagen layer thicknesses and the numbers of estrogen receptor-positive cells are presented in box plots (Figures 1 and 2).


Histological investigation of the effect of soybean (Glycine max) extracts on the collagen layer and estrogen receptors in the skin of female rats.

Uyar B, Sivrikoz ON, Ozdemir U, Dasbasi T, Sacar H - Clinics (Sao Paulo) (2014)

The collagen layer thicknesses are presented in a box plot.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4286672&req=5

f1-cln_69p854: The collagen layer thicknesses are presented in a box plot.
Mentions: The mean values of collagen layer thickness and number of estrogen receptor-positive cells in the different soybean extract-treated groups are shown in Table 1. The collagen layer thicknesses and the numbers of estrogen receptor-positive cells are presented in box plots (Figures 1 and 2).

Bottom Line: The groups comprised carboxymethyl cellulose-free control, carboxymethyl cellulose-plus control, 100-mg/kg n-hexane extract, 200-mg/kg n-hexane extract, 100-mg/kg ethyl acetate extract, 200-mg/kg ethyl acetate extract, 100-mg/kg ethanol extract and 200-mg/kg ethanol extract groups.Regarding the thickness of the collagen layer, only the 200-mg/kg ethyl acetate extract-treated group showed a significant increase compared with the control groups (p<0.05).Our data suggest that oral intake of three different total soybean extracts might have positive estrogenic effects on the skin and that only a high-dose ethyl acetate extract can increase the expression of collagen, which may prove to be beneficial for postmenopausal facial skin.

View Article: PubMed Central - PubMed

Affiliation: Department of Dermatology, Faculty of Medicine, Sifa University, Izmir, Turkey.

ABSTRACT

Objectives: The purpose of this study was to analyze the effects of soybean extracts obtained using different extraction methods on the skin of female rats.

Method: A total of 64 female Sprague-Dawley rats were divided into 8 equal groups. Various extracts were administered to the female rats by oral gavage for one month. The groups comprised carboxymethyl cellulose-free control, carboxymethyl cellulose-plus control, 100-mg/kg n-hexane extract, 200-mg/kg n-hexane extract, 100-mg/kg ethyl acetate extract, 200-mg/kg ethyl acetate extract, 100-mg/kg ethanol extract and 200-mg/kg ethanol extract groups. The thickness of the collagen layer and the number of estrogen receptor-positive cells were evaluated.

Results: All the extract-treated groups showed a statistically significant decrease in the number of estrogen receptor-positive cells compared with the control groups. Regarding the thickness of the collagen layer, only the 200-mg/kg ethyl acetate extract-treated group showed a significant increase compared with the control groups (p<0.05).

Conclusions: Our data suggest that oral intake of three different total soybean extracts might have positive estrogenic effects on the skin and that only a high-dose ethyl acetate extract can increase the expression of collagen, which may prove to be beneficial for postmenopausal facial skin.

Show MeSH
Related in: MedlinePlus