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Mucociliary clearance, airway inflammation and nasal symptoms in urban motorcyclists.

Brant TC, Yoshida CT, Carvalho Tde S, Nicola ML, Martins JA, Braga LM, Oliveira RC, Leyton V, André CS, Saldiva PH, Rubin BK, Nakagawa NK - Clinics (Sao Paulo) (2014)

Bottom Line: We hypothesized that these workers would experience increased airway symptoms and decreased nasal mucociliary clearance associated with their exposure to air pollution.The associations between NO2 and the airway outcomes were analyzed using the Mann-Whitney test and the Chi-Square test.Non-smoking commercial motorcyclists exhibit increased airway symptoms and airway acidification as well as decreased nasal mucociliary clearance, all of which are significantly associated with the amount of exposure to air pollution.

View Article: PubMed Central - PubMed

Affiliation: Department of Pathology, Faculdade de Medicina da Universidade de São Paulo, São Paulo, SP, Brazil.

ABSTRACT

Objectives: There is evidence that outdoor workers exposed to high levels of air pollution exhibit airway inflammation and increased airway symptoms. We hypothesized that these workers would experience increased airway symptoms and decreased nasal mucociliary clearance associated with their exposure to air pollution.

Methods: In total, 25 non-smoking commercial motorcyclists, aged 18-44 years, were included in this study. These drivers work 8-12 hours per day, 5 days per week, driving on urban streets. Nasal mucociliary clearance was measured by the saccharine transit test; airway acidification was measured by assessing the pH of exhaled breath condensate; and airway symptoms were measured by the Sino-nasal Outcome Test-20 questionnaire. To assess personal air pollution exposure, the subjects used a passive-diffusion nitrogen dioxide (NO2) concentration-monitoring system during the 14 days before each assessment. The associations between NO2 and the airway outcomes were analyzed using the Mann-Whitney test and the Chi-Square test. Clinicaltrials.gov: NCT01976039.

Results: Compared with clearance in healthy adult males, mucociliary clearance was decreased in 32% of the motorcyclists. Additionally, 64% of the motorcyclists had airway acidification and 92% experienced airway symptoms. The median personal NO2 exposure level was 75 mg/m3 for these subjects and a significant association was observed between NO2 and impaired mucociliary clearance (p=0.036).

Conclusion: Non-smoking commercial motorcyclists exhibit increased airway symptoms and airway acidification as well as decreased nasal mucociliary clearance, all of which are significantly associated with the amount of exposure to air pollution.

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Related in: MedlinePlus

Motorcyclist recruitment.
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f1-cln_69p867: Motorcyclist recruitment.

Mentions: In total, 25 subjects were enrolled in the study (Figure 1). The median in motorcycle delivery was 12 years (IQR: 11.5), with a median daily working time of 10 hours (IQR: 4) for 5 days each week. Demographic and clinical data are shown in Table 1. Exhaled CO was within the normal range for non-smoking subjects. Spirometry showed normal lung function in all subjects.


Mucociliary clearance, airway inflammation and nasal symptoms in urban motorcyclists.

Brant TC, Yoshida CT, Carvalho Tde S, Nicola ML, Martins JA, Braga LM, Oliveira RC, Leyton V, André CS, Saldiva PH, Rubin BK, Nakagawa NK - Clinics (Sao Paulo) (2014)

Motorcyclist recruitment.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4286667&req=5

f1-cln_69p867: Motorcyclist recruitment.
Mentions: In total, 25 subjects were enrolled in the study (Figure 1). The median in motorcycle delivery was 12 years (IQR: 11.5), with a median daily working time of 10 hours (IQR: 4) for 5 days each week. Demographic and clinical data are shown in Table 1. Exhaled CO was within the normal range for non-smoking subjects. Spirometry showed normal lung function in all subjects.

Bottom Line: We hypothesized that these workers would experience increased airway symptoms and decreased nasal mucociliary clearance associated with their exposure to air pollution.The associations between NO2 and the airway outcomes were analyzed using the Mann-Whitney test and the Chi-Square test.Non-smoking commercial motorcyclists exhibit increased airway symptoms and airway acidification as well as decreased nasal mucociliary clearance, all of which are significantly associated with the amount of exposure to air pollution.

View Article: PubMed Central - PubMed

Affiliation: Department of Pathology, Faculdade de Medicina da Universidade de São Paulo, São Paulo, SP, Brazil.

ABSTRACT

Objectives: There is evidence that outdoor workers exposed to high levels of air pollution exhibit airway inflammation and increased airway symptoms. We hypothesized that these workers would experience increased airway symptoms and decreased nasal mucociliary clearance associated with their exposure to air pollution.

Methods: In total, 25 non-smoking commercial motorcyclists, aged 18-44 years, were included in this study. These drivers work 8-12 hours per day, 5 days per week, driving on urban streets. Nasal mucociliary clearance was measured by the saccharine transit test; airway acidification was measured by assessing the pH of exhaled breath condensate; and airway symptoms were measured by the Sino-nasal Outcome Test-20 questionnaire. To assess personal air pollution exposure, the subjects used a passive-diffusion nitrogen dioxide (NO2) concentration-monitoring system during the 14 days before each assessment. The associations between NO2 and the airway outcomes were analyzed using the Mann-Whitney test and the Chi-Square test. Clinicaltrials.gov: NCT01976039.

Results: Compared with clearance in healthy adult males, mucociliary clearance was decreased in 32% of the motorcyclists. Additionally, 64% of the motorcyclists had airway acidification and 92% experienced airway symptoms. The median personal NO2 exposure level was 75 mg/m3 for these subjects and a significant association was observed between NO2 and impaired mucociliary clearance (p=0.036).

Conclusion: Non-smoking commercial motorcyclists exhibit increased airway symptoms and airway acidification as well as decreased nasal mucociliary clearance, all of which are significantly associated with the amount of exposure to air pollution.

Show MeSH
Related in: MedlinePlus