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Hematological and iron content evolution in exclusively breastfed late-preterm newborns.

Yamada RT, Leone CR - Clinics (Sao Paulo) (2014)

Bottom Line: Cohort study.Ferritin did not differ between the groups.Exclusively breastfed late-preterm newborns presented greater reductions in hemoglobin/hematocrit and lower iron stores at a corrected gestational age of one month post-term than did term newborns, suggesting specific iron supplementation needs.

View Article: PubMed Central - PubMed

Affiliation: Department of Pediatrics, Faculdade de Medicina da Universidade de São Paulo, São Paulo, SP, Brazil.

ABSTRACT

Objectives: To analyze and compare the evolution of hematological parameters and body iron content between exclusively breastfed late-preterm and term newborns during the first two months of life.

Methods: Cohort study. Weight, length, head circumference, body mass index, hemoglobin, hematocrit, reticulocytes, total iron-binding capacity, transferrin saturation, serum iron and ferritin were measured in 25 late-preterm and 21 term newborns (at birth and at one and two months of age) who were exclusively breastfed.

Statistical analysis: Kolmogorov-Smirnov test, one-way ANOVA or Kruskal-Wallis test; and Student's t-test or Mann-Whitney test.

Significance: p<0.05.

Results: The corrected gestational ages of the late-preterm infants were 39.98 weeks at one month of life and 44.53 weeks at two months. Anthropometric measures and the body mass index increased over time (p<0.001) and hemoglobin, hematocrit, reticulocytes and body iron content decreased (p<0.001). Late-preterm infants at term corrected gestational age had reduced hemoglobin, hematocrit and reticulocyte concentrations, and reduced total iron-binding capacity (p<0.001) and serum iron (p=0.0034) compared with values observed in term newborns at birth. Late-preterm newborns at a corrected gestational age of one month post-term had hemoglobin (p=0.0002), hematocrit (p=0.0008), iron (p<0.0001) and transferrin saturation (p<0.001) levels lower than those of term newborns at one month of age and a higher total iron-binding capacity (p=0.0018). Ferritin did not differ between the groups.

Conclusion: Exclusively breastfed late-preterm newborns presented greater reductions in hemoglobin/hematocrit and lower iron stores at a corrected gestational age of one month post-term than did term newborns, suggesting specific iron supplementation needs.

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Hemoglobin levels of late-preterm newborns at term corrected gestational age and of term newborns at birth.
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f1-cln_69p792: Hemoglobin levels of late-preterm newborns at term corrected gestational age and of term newborns at birth.

Mentions: Hb and Ht (Table 3) mainly decreased in the LPT newborns (p<0.001). At birth, a difference between the two groups was observed only for Ht (p = 0.010), whereas at two months, more dramatic differences in both Hb (p = 0.020) and Ht (p<0.001) were present. At corrected GAs of both term and one month post-T, the concentrations of Hb and Ht in the LPT newborns were lower than those in the term newborns (Table 3). Box plot analysis indicated greater dispersion values for LPT newborns at term corrected GA than for term newborns at birth, whereas the dispersion was greater for term newborns at one month of age than for LPT newborns at a corrected GA of one month (Figures 1 and 2). In both analyses, the median Hb values were higher in term newborns compared with LPT newborns at either term corrected GA (p<0.001) or a corrected GA of one month post-T (p = 0.0013).


Hematological and iron content evolution in exclusively breastfed late-preterm newborns.

Yamada RT, Leone CR - Clinics (Sao Paulo) (2014)

Hemoglobin levels of late-preterm newborns at term corrected gestational age and of term newborns at birth.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4286666&req=5

f1-cln_69p792: Hemoglobin levels of late-preterm newborns at term corrected gestational age and of term newborns at birth.
Mentions: Hb and Ht (Table 3) mainly decreased in the LPT newborns (p<0.001). At birth, a difference between the two groups was observed only for Ht (p = 0.010), whereas at two months, more dramatic differences in both Hb (p = 0.020) and Ht (p<0.001) were present. At corrected GAs of both term and one month post-T, the concentrations of Hb and Ht in the LPT newborns were lower than those in the term newborns (Table 3). Box plot analysis indicated greater dispersion values for LPT newborns at term corrected GA than for term newborns at birth, whereas the dispersion was greater for term newborns at one month of age than for LPT newborns at a corrected GA of one month (Figures 1 and 2). In both analyses, the median Hb values were higher in term newborns compared with LPT newborns at either term corrected GA (p<0.001) or a corrected GA of one month post-T (p = 0.0013).

Bottom Line: Cohort study.Ferritin did not differ between the groups.Exclusively breastfed late-preterm newborns presented greater reductions in hemoglobin/hematocrit and lower iron stores at a corrected gestational age of one month post-term than did term newborns, suggesting specific iron supplementation needs.

View Article: PubMed Central - PubMed

Affiliation: Department of Pediatrics, Faculdade de Medicina da Universidade de São Paulo, São Paulo, SP, Brazil.

ABSTRACT

Objectives: To analyze and compare the evolution of hematological parameters and body iron content between exclusively breastfed late-preterm and term newborns during the first two months of life.

Methods: Cohort study. Weight, length, head circumference, body mass index, hemoglobin, hematocrit, reticulocytes, total iron-binding capacity, transferrin saturation, serum iron and ferritin were measured in 25 late-preterm and 21 term newborns (at birth and at one and two months of age) who were exclusively breastfed.

Statistical analysis: Kolmogorov-Smirnov test, one-way ANOVA or Kruskal-Wallis test; and Student's t-test or Mann-Whitney test.

Significance: p<0.05.

Results: The corrected gestational ages of the late-preterm infants were 39.98 weeks at one month of life and 44.53 weeks at two months. Anthropometric measures and the body mass index increased over time (p<0.001) and hemoglobin, hematocrit, reticulocytes and body iron content decreased (p<0.001). Late-preterm infants at term corrected gestational age had reduced hemoglobin, hematocrit and reticulocyte concentrations, and reduced total iron-binding capacity (p<0.001) and serum iron (p=0.0034) compared with values observed in term newborns at birth. Late-preterm newborns at a corrected gestational age of one month post-term had hemoglobin (p=0.0002), hematocrit (p=0.0008), iron (p<0.0001) and transferrin saturation (p<0.001) levels lower than those of term newborns at one month of age and a higher total iron-binding capacity (p=0.0018). Ferritin did not differ between the groups.

Conclusion: Exclusively breastfed late-preterm newborns presented greater reductions in hemoglobin/hematocrit and lower iron stores at a corrected gestational age of one month post-term than did term newborns, suggesting specific iron supplementation needs.

Show MeSH