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Optic radiation structure and anatomy in the normally developing brain determined using diffusion MRI and tractography.

Dayan M, Munoz M, Jentschke S, Chadwick MJ, Cooper JM, Riney K, Vargha-Khadem F, Clark CA - Brain Struct Funct (2013)

Bottom Line: Left lateralization of DTI metrics was observed that showed a gender effect in lateralization.Sexual dimorphism of DTI metrics in the right hemisphere was also found.The anatomical results presented for the OR have potentially important applications for neurosurgical planning.

View Article: PubMed Central - PubMed

Affiliation: Imaging and Biophysics Unit, UCL Institute of Child Health, London, UK, mdayan.research@gmail.com.

ABSTRACT
The optic radiation (OR) is a component of the visual system known to be myelin mature very early in life. Diffusion tensor imaging (DTI) and its unique ability to reconstruct the OR in vivo were used to study structural maturation through analysis of DTI metrics in a cohort of 90 children aged 5-18 years. As the OR is at risk of damage during epilepsy surgery, we measured its position relative to characteristic anatomical landmarks. Anatomical distances, DTI metrics and volume of the OR were investigated for age, gender and hemisphere effects. We observed changes in DTI metrics with age comparable to known trajectories in other white matter tracts. Left lateralization of DTI metrics was observed that showed a gender effect in lateralization. Sexual dimorphism of DTI metrics in the right hemisphere was also found. With respect to OR dimensions, volume was shown to be right lateralised and sexual dimorphism demonstrated for the extent of the left OR. The anatomical results presented for the OR have potentially important applications for neurosurgical planning.

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Volume in cm3 in the left OR and right OR. A star indicates a significant side effect (p < 0.05)
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Fig11: Volume in cm3 in the left OR and right OR. A star indicates a significant side effect (p < 0.05)

Mentions: After being differentiated with respect to hemisphere (left and right), each of the side variables was tested for gender and age effect. No evidence for a gender effect from the MRA was found, nor was an age effect observed for either hemisphere. Therefore, the track volumes were averaged across age. The values of the volume computed in the left and right OR (mean ± SE) were 11.45 ± 0.27 and 13.53 ± 0.34 cm3, respectively. The significant side effect is illustrated in Fig. 11.Fig. 11


Optic radiation structure and anatomy in the normally developing brain determined using diffusion MRI and tractography.

Dayan M, Munoz M, Jentschke S, Chadwick MJ, Cooper JM, Riney K, Vargha-Khadem F, Clark CA - Brain Struct Funct (2013)

Volume in cm3 in the left OR and right OR. A star indicates a significant side effect (p < 0.05)
© Copyright Policy - OpenAccess
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC4286633&req=5

Fig11: Volume in cm3 in the left OR and right OR. A star indicates a significant side effect (p < 0.05)
Mentions: After being differentiated with respect to hemisphere (left and right), each of the side variables was tested for gender and age effect. No evidence for a gender effect from the MRA was found, nor was an age effect observed for either hemisphere. Therefore, the track volumes were averaged across age. The values of the volume computed in the left and right OR (mean ± SE) were 11.45 ± 0.27 and 13.53 ± 0.34 cm3, respectively. The significant side effect is illustrated in Fig. 11.Fig. 11

Bottom Line: Left lateralization of DTI metrics was observed that showed a gender effect in lateralization.Sexual dimorphism of DTI metrics in the right hemisphere was also found.The anatomical results presented for the OR have potentially important applications for neurosurgical planning.

View Article: PubMed Central - PubMed

Affiliation: Imaging and Biophysics Unit, UCL Institute of Child Health, London, UK, mdayan.research@gmail.com.

ABSTRACT
The optic radiation (OR) is a component of the visual system known to be myelin mature very early in life. Diffusion tensor imaging (DTI) and its unique ability to reconstruct the OR in vivo were used to study structural maturation through analysis of DTI metrics in a cohort of 90 children aged 5-18 years. As the OR is at risk of damage during epilepsy surgery, we measured its position relative to characteristic anatomical landmarks. Anatomical distances, DTI metrics and volume of the OR were investigated for age, gender and hemisphere effects. We observed changes in DTI metrics with age comparable to known trajectories in other white matter tracts. Left lateralization of DTI metrics was observed that showed a gender effect in lateralization. Sexual dimorphism of DTI metrics in the right hemisphere was also found. With respect to OR dimensions, volume was shown to be right lateralised and sexual dimorphism demonstrated for the extent of the left OR. The anatomical results presented for the OR have potentially important applications for neurosurgical planning.

Show MeSH
Related in: MedlinePlus