Limits...
Developmental telomere attrition predicts impulsive decision-making in adult starlings.

Bateson M, Brilot BO, Gillespie R, Monaghan P, Nettle D - Proc. Biol. Sci. (2015)

Bottom Line: Animals in a poor biological state face reduced life expectancy, and as a consequence should make decisions that prioritize immediate survival and reproduction over long-term benefits.We show that as predicted by state-dependent optimality models, individuals who had sustained greater developmental telomere attrition and who had shorter current telomeres made more impulsive foraging decisions as adults, valuing smaller, sooner food rewards more highly than birds with less attrition and longer telomeres.Our findings shed light on the biological embedding of early adversity and support a functional explanation for its consequences that could be applicable to other species, including humans.

View Article: PubMed Central - PubMed

Affiliation: Centre for Behaviour and Evolution, Institute of Neuroscience and Newcastle University Institute of Ageing, Newcastle University, Newcastle upon Tyne, UK melissa.bateson@ncl.ac.uk.

ABSTRACT
Animals in a poor biological state face reduced life expectancy, and as a consequence should make decisions that prioritize immediate survival and reproduction over long-term benefits. We tested the prediction that if, as has been suggested, developmental telomere attrition is a biomarker of state and future life expectancy, then individuals who have undergone greater developmental telomere attrition should display greater choice impulsivity as adults. We measured impulsive decision-making in a cohort of European starlings (Sturnus vulgaris) in which we had previously manipulated developmental telomere attrition by cross-fostering sibling chicks into broods of different sizes. We show that as predicted by state-dependent optimality models, individuals who had sustained greater developmental telomere attrition and who had shorter current telomeres made more impulsive foraging decisions as adults, valuing smaller, sooner food rewards more highly than birds with less attrition and longer telomeres. Our findings shed light on the biological embedding of early adversity and support a functional explanation for its consequences that could be applicable to other species, including humans.

Show MeSH

Related in: MedlinePlus

Telomere dynamics. (a) Having more, heavier competitors on d15 predicts greater developmental telomere attrition between d4 and d55. Telomere attrition is measured by D [22]; positive values of D indicate telomere lengthening over development and negative values indicate telomere loss. The solid black line is the line of best fit from a simple linear regression model, with 95% CIs shaded in grey. (b) Correlation between telomere length at d55 and telomere length at 14 months. The units of measurement are T/S ratios. The solid line shows the expectation if there was no change in telomere length. (c) Greater developmental telomere attrition (D) predicts shorter telomere length (T/S ratios) at 14 months. The graphs show data from all 23 birds for which we had telomere length measurements; the three birds lacking behavioural data are indicated with open circles.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
getmorefigures.php?uid=PMC4286045&req=5

RSPB20142140F2: Telomere dynamics. (a) Having more, heavier competitors on d15 predicts greater developmental telomere attrition between d4 and d55. Telomere attrition is measured by D [22]; positive values of D indicate telomere lengthening over development and negative values indicate telomere loss. The solid black line is the line of best fit from a simple linear regression model, with 95% CIs shaded in grey. (b) Correlation between telomere length at d55 and telomere length at 14 months. The units of measurement are T/S ratios. The solid line shows the expectation if there was no change in telomere length. (c) Greater developmental telomere attrition (D) predicts shorter telomere length (T/S ratios) at 14 months. The graphs show data from all 23 birds for which we had telomere length measurements; the three birds lacking behavioural data are indicated with open circles.

Mentions: To test whether developmental telomere attrition was predicted by our experimental manipulation, we fitted a model with ln(D + 2) as the dependent variable and the number of heavier competitors that a chick had at d15 as a continuous fixed predictor. The number of heavier competitors significantly predicted D, with birds with more heavier competitors experiencing greater telomere attrition (GLMM: p = 0.0079; B ± s.e. = −0.07 ± 0.02; figure 2a).Figure 2.


Developmental telomere attrition predicts impulsive decision-making in adult starlings.

Bateson M, Brilot BO, Gillespie R, Monaghan P, Nettle D - Proc. Biol. Sci. (2015)

Telomere dynamics. (a) Having more, heavier competitors on d15 predicts greater developmental telomere attrition between d4 and d55. Telomere attrition is measured by D [22]; positive values of D indicate telomere lengthening over development and negative values indicate telomere loss. The solid black line is the line of best fit from a simple linear regression model, with 95% CIs shaded in grey. (b) Correlation between telomere length at d55 and telomere length at 14 months. The units of measurement are T/S ratios. The solid line shows the expectation if there was no change in telomere length. (c) Greater developmental telomere attrition (D) predicts shorter telomere length (T/S ratios) at 14 months. The graphs show data from all 23 birds for which we had telomere length measurements; the three birds lacking behavioural data are indicated with open circles.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4286045&req=5

RSPB20142140F2: Telomere dynamics. (a) Having more, heavier competitors on d15 predicts greater developmental telomere attrition between d4 and d55. Telomere attrition is measured by D [22]; positive values of D indicate telomere lengthening over development and negative values indicate telomere loss. The solid black line is the line of best fit from a simple linear regression model, with 95% CIs shaded in grey. (b) Correlation between telomere length at d55 and telomere length at 14 months. The units of measurement are T/S ratios. The solid line shows the expectation if there was no change in telomere length. (c) Greater developmental telomere attrition (D) predicts shorter telomere length (T/S ratios) at 14 months. The graphs show data from all 23 birds for which we had telomere length measurements; the three birds lacking behavioural data are indicated with open circles.
Mentions: To test whether developmental telomere attrition was predicted by our experimental manipulation, we fitted a model with ln(D + 2) as the dependent variable and the number of heavier competitors that a chick had at d15 as a continuous fixed predictor. The number of heavier competitors significantly predicted D, with birds with more heavier competitors experiencing greater telomere attrition (GLMM: p = 0.0079; B ± s.e. = −0.07 ± 0.02; figure 2a).Figure 2.

Bottom Line: Animals in a poor biological state face reduced life expectancy, and as a consequence should make decisions that prioritize immediate survival and reproduction over long-term benefits.We show that as predicted by state-dependent optimality models, individuals who had sustained greater developmental telomere attrition and who had shorter current telomeres made more impulsive foraging decisions as adults, valuing smaller, sooner food rewards more highly than birds with less attrition and longer telomeres.Our findings shed light on the biological embedding of early adversity and support a functional explanation for its consequences that could be applicable to other species, including humans.

View Article: PubMed Central - PubMed

Affiliation: Centre for Behaviour and Evolution, Institute of Neuroscience and Newcastle University Institute of Ageing, Newcastle University, Newcastle upon Tyne, UK melissa.bateson@ncl.ac.uk.

ABSTRACT
Animals in a poor biological state face reduced life expectancy, and as a consequence should make decisions that prioritize immediate survival and reproduction over long-term benefits. We tested the prediction that if, as has been suggested, developmental telomere attrition is a biomarker of state and future life expectancy, then individuals who have undergone greater developmental telomere attrition should display greater choice impulsivity as adults. We measured impulsive decision-making in a cohort of European starlings (Sturnus vulgaris) in which we had previously manipulated developmental telomere attrition by cross-fostering sibling chicks into broods of different sizes. We show that as predicted by state-dependent optimality models, individuals who had sustained greater developmental telomere attrition and who had shorter current telomeres made more impulsive foraging decisions as adults, valuing smaller, sooner food rewards more highly than birds with less attrition and longer telomeres. Our findings shed light on the biological embedding of early adversity and support a functional explanation for its consequences that could be applicable to other species, including humans.

Show MeSH
Related in: MedlinePlus